Abstract
The necessity of two operations and high costs required by autologous chondrocyte implantation (ACI) procedure prompted the search for new methods for cartilage repair. Bone marrow-derived cell transplantation (BMDCT) has been proposed as a technique capable of providing a repair of the lesion by hyaline cartilage in a one-step procedure. Mesenchymal stem cells have the ability to differentiate into osteoblasts and chondroblasts. The rationale of the “one-step technique” is to transplant the entire bone-marrow cellular pool instead of isolated and expanded mesenchymal stem cells allowing cells to be processed directly in the operating room, without the need for a laboratory phase. A scaffold and the instrumentation previously used for ACI are employed for an entirely arthroscopic implantation. Autologous platelet-rich fibrin (PRF) is added in order to provide a supplement of growth factors. Results of this technique are encouraging at mid-term although long-term follow-up is still needed.
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Bone marrow aspiration (https://drive.google.com/open?id=0BwW4vpbLQ22Pbm5ueDloVGxWRDg) (MP4 241,291 kb)
Bone marrow concentration (https://drive.google.com/open?id=0BwW4vpbLQ22PWHAzakEzTlNhM28) (MP4 312,829 kb)
Surgical procedure (https://drive.google.com/open?id=0BwW4vpbLQ22PUG9jdkFkLUhOdU0) (MP4 596,344 kb)
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Buda, R., Perazzo, L., Baldassarri, M., Pantalone, A., Bruni, D. (2020). Restore by Mesenchymal Cells. In: Allegra, F., Cortese, F., Lijoi, F. (eds) Ankle Joint Arthroscopy. Springer, Cham. https://doi.org/10.1007/978-3-030-29231-7_12
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DOI: https://doi.org/10.1007/978-3-030-29231-7_12
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