Abstract
Articular cartilage does not contain vascular, nervous, and lymphatic tissues. The absence of trophic support and the lack of access to reparative and humoral factors that promote tissue healing determine a limited repair potential of cartilage lesions [1, 2]. Due to this limited ability of regeneration in response to injury and the scarcity of therapeutic options, even minor articular cartilage lesions may lead to progressive damage and joint degeneration [3, 4]. For all these reasons, chondral lesions have always been considered difficult to treat [5]. Many therapeutic strategies were set up over the last years. Nonoperative treatment is useful only for symptoms relief and it should represent the first approach to the patient. When surgery is needed, treatment includes one-step procedures, such as cartilage debridment [6], microfractures, and osteochondral autograft transfer system (OATS) [7], and two-steps approach, including chondrocyte implantation (ACI) [8] and matrix-induced autologous chondrocytes trasplantation (MACI) [9].
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References
Hui JHP, Buhary KS, Chowdhary A. Implantation of orthobiologic, biodegradable scaffolds in osteochondral repair. Orthop Clin N Am. 2012;43:255–61.
Seo SS, Kim CW, Jung DW. Management of focal chondral lesion in the knee joint. Knee Surg Relat Res. 2011;23(4):185–96.
Seo S, Na K. Mesenchymal stem cell-based tissue engineering for chondrogenesis. J Biomed Biotechnol. 2011;2011:806891.
Steinwachs MR, Guggi T, Kreuz PC. Marrow stimulation techniques. Injury. 2008;39S1:S26–31.
Pelttari K, Steck E, Richter W. The use of mesenchymal stem cells for chondrogenesis. Injury. 2008;39S1:S58–65.
Barnes CJ, Ferkel RD. Arthroscopic debridement and drilling of osteochondral lesion of the talus. Foot Ankle Clin. 2003;8(2):243–57.
Imhoff AB, Paul J, Ottinger B, et al. Osteochondral transplantation of the talus: long term clinical and magnetic resonance imaging evaluation. Am J Sports Med. 2011;39(7):1487–8.
Giannini S, Buda R, Vannini F. Autologous chondrocyte traspalntation in osteochondral lesion of the ankle joint. Foot Ankle Int. 2001;22(6):513–7.
Ronga M, Grassi FA. Treatment of deep cartilage defects of the ankle with matrix-induced autologous chondrocyte implantation (MACI). Foot Ankle Surg. 2005;11:29–33.
Steadman JR, Rodkey WG, Rodrigo JJ. Microfracture: surgical technique and rehabilitation to treat chondral defects. Clin Orthop Relat Res. 2001;391(Suppl):S362–9.
Valderrabano V, Miska M, Leumann A, Wiewiorski M. Reconstruction of osteochondral lesion of the talus with autologous spongiosa graft and autologous matrix-induced chondogenesis. Am J Sports Med. 2013;41(3):519–27.
Volpi P, Bait C, Quaglia A, et al. Autologous collagen-induced chondrogenesis technique (ACIC) for the treatment of chondral lesions of the talus. Knee Surg Sports Traumatol Arthrosc. 2014;22:1320–6.
Shetty AA, Kim SJ, Bilagi P, Stelzeneder D. Autologous collagen-induced chondrogenesis: single-stage arthroscopic cartilage repair technique. Orthopedics. 2013;36(5):e648–52.
Van Dijk CN, Verhagen RA, Struijis PA, et al. Systematic review of treatment strategies for osteochondral defects of the talar dome. Foot Ankle Clin. 2003;8(2):233–42.
Gobbi A, Francisco RA, Lubowitz JH, Allegra F, Canata G. Osteochondral lesions of the talus: randomized controlled trial comparing chondroplasty, microfracture and osteochondral autograft transplantation. Arthroscopy. 2006;22(10):1085–92.
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Volpi, P., Quaglia, A., de Girolamo, L. (2020). Repair by Autologous Collagen-Induced Chondrogenesis (ACIC) Technique. In: Allegra, F., Cortese, F., Lijoi, F. (eds) Ankle Joint Arthroscopy. Springer, Cham. https://doi.org/10.1007/978-3-030-29231-7_11
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