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Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis pp 433–456Cite as

Mannose Receptor and Targeting Strategies

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Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 39))

Abstract

The mannose family receptors are unique multidomain, multifunctional endocytic receptors belonging to the C-type lectin family. These receptors, although structurally similar, exhibit differential binding to discrete ligands. This chapter discusses such similarities and differences between the structures, ligands, the expression, and molecular trafficking among the members of mannose receptor family. Further, targeted drug delivery strategies in infections and cancer to the most widely investigated receptor of the family, the mannose receptor, are comprehensively explained with examples.

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Abbreviations

CD:

Cluster of differentiation

CTLD:

C-type lectin domain

DCs:

Dendritic cells

DRV:

Dehydration–rehydration vesicle

HIV:

Human Immunodeficiency Virus

IFN:

Interferon

IL:

Interleukin

LAM:

Lipoarabinomannan

LPS:

Lipopolysaccharide

MMP:

Matrix metalloproteinases

MRI:

Magnetic resonance imaging

NPs:

Nanoparticles

PEG:

Polyethylene glycol

PLA2:

Phospholipase A2

PLGA:

Poly (lactide-co-glycolide)

RES:

Reticuloendothelial system

SLA:

Soluble leishmanial antigen

SPIONs:

Superparamagnetic iron oxide nanoparticles

TAM:

Tumor-associated macrophages

TB:

Tuberculosis

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Author notes

  1. Priyanka Jahagirdar and Amit S. Lokhande have contributed equally to this work.

Authors and Affiliations

  1. Department of Pharmaceutical Sciences & Technology, Institute of Chemical Technology, Matunga, Mumbai, India

    Priyanka Jahagirdar & Amit S. Lokhande

  2. Department of Pharmaceutical Sciences, Insitute of Chemical Technology, Deemed University, Elite Status and Centre of Excellence, Government of Maharashtra, Mumbai, India

    Prajakta Dandekar & Padma V. Devarajan

Authors
  1. Priyanka Jahagirdar
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  2. Amit S. Lokhande
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  3. Prajakta Dandekar
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  4. Padma V. Devarajan
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Correspondence to Padma V. Devarajan .

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Editors and Affiliations

  1. Department of Pharmaceutical Sciences, Insitute of Chemical Technology Deemed University, Elite Status and Centre of Excellence Government of Maharashtra, Mumbai, India

    Padma V. Devarajan

  2. Department of Pharmaceutical Sciences, Insitute of Chemical Technology Deemed University, Elite Status and Centre of Excellence Government of Maharashtra, Mumbai, India

    Prajakta Dandekar

  3. Piramal Enterprises Limited, Pharmaceutical R&D, Mumbai, India

    Anisha A. D'Souza

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Jahagirdar, P., Lokhande, A.S., Dandekar, P., Devarajan, P.V. (2019). Mannose Receptor and Targeting Strategies. In: Devarajan, P., Dandekar, P., D'Souza, A. (eds) Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis. AAPS Advances in the Pharmaceutical Sciences Series, vol 39. Springer, Cham. https://doi.org/10.1007/978-3-030-29168-6_15

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