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How the Sleeve Gastrectomy Works: Metabolically

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The Perfect Sleeve Gastrectomy

Abstract

Sleeve gastrectomy (SG) has become the most popular bariatric operation in recent years. Its relative technical ease compared to other metabolic and bariatric operations has allowed SG to become one of the most studied bariatric operations in preclinical models, which has led to a number of novel insights and potential shared mechanisms across bariatric operations. Herein, the rationale for the weight loss and metabolic changes associated with bariatric surgery is discussed, including contributions of gastrointestinal hormones, nutrient delivery and bile acid metabolic changes that have recently been implicated in preclinical studies as being necessary for the efficacy of SG. Commonly cited theoretical mechanisms that have been debunked are also mentioned. Despite significant progress on the mechanisms underlying SG, a single driving force has not yet been identified – and most likely not be identified as multiple factors contribute to the metabolic benefits of SG.

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Authors and Affiliations

  1. Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, OH, USA

    Vance L. Albaugh, Philip R. Schauer & Ali Aminian

Authors
  1. Vance L. Albaugh
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  2. Philip R. Schauer
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  3. Ali Aminian
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Correspondence to Vance L. Albaugh .

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Editors and Affiliations

  1. Department of Surgery, Sacré-Coeur Hospital, Montréal, QC, Canada

    Michel Gagner

  2. Bariatric Surgery, Gastro Obeso Center, Sao Paulo, Brazil

    Almino Ramos Cardoso

  3. Diagnomed, University of Buenos Aires, Buenos Aires, Argentina

    Mariano Palermo

  4. Emirates Specialty Hospital, Dubai, United Arab Emirates

    Patrick Noel

  5. CHU Montpellier, Saint Gely du Fesc, France

    David Nocca

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Albaugh, V.L., Schauer, P.R., Aminian, A. (2020). How the Sleeve Gastrectomy Works: Metabolically. In: Gagner, M., Cardoso, A., Palermo, M., Noel, P., Nocca, D. (eds) The Perfect Sleeve Gastrectomy. Springer, Cham. https://doi.org/10.1007/978-3-030-28936-2_6

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  • DOI: https://doi.org/10.1007/978-3-030-28936-2_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-28935-5

  • Online ISBN: 978-3-030-28936-2

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