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Wound Healing in Pyoderma Gangrenosum

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Local Wound Care for Dermatologists

Part of the book series: Updates in Clinical Dermatology ((UCD))

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Abstract

Pyoderma gangrenosum (PG) is an ulcerative painful, chronic neutrophilic dermatosis that is often associated with an underlying illness. There is limited evidence on the best treatment for PG, and first-line systemic therapies are associated with adverse events. In order to optimize therapeutics, topical therapy and local wound care should be carefully addressed. Topical therapies for PG include topical and intralesional immunosuppressants, immunomodulators, and alternative therapies. Multiple moisture-retentive dressings and compression therapy have been used to promote healing. Less often used but still beneficial for more severe cases are negative pressure wound therapy and skin substitutes. PG is not only a physical disease but affects patients psychologically as well. A therapeutic relationship must be maintained to provide holistic care and achieve common ground with the patient in order to ensure patient adherence.

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Conflict of Interest

  • AAA and AVM have no conflict of interest to declare.

  • AA has consulted for AbbVie, Janssen, LEO, Galderma, Novartis, and Valeant and is also an investigator for AbbVie, Novartis, Regeneron, Pfizer, Boehringer-Ingelheim, Glenmark, Merck Serono, Roche, Xoma, and Xenon. AA received an unrestricted educational grant from AbbVie.

  • All authors state no conflict related to this manuscript.

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Authors and Affiliations

  1. Department of Dermatology, University of Calgary, Calgary, AB, Canada

    Asma Asif Amir Ali

  2. Hospital Dermatology Unit, Fondazione ,Irccs Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    Angelo Valerio Marzano

  3. Division of Dermatology, Department of Medicine, Women’s College Hospital, University of Toronto, Toronto, ON, Canada

    Afsaneh Alavi

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  1. Asma Asif Amir Ali
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  2. Angelo Valerio Marzano
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  3. Afsaneh Alavi
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Correspondence to Angelo Valerio Marzano .

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Editors and Affiliations

  1. Division of Dermatology, Department of Medicine, Women’s College Hospital, University of Toronto, Toronto, ON, Canada

    Afsaneh Alavi

  2. Department of Dermatology, University of San Francisco, San Francisco, CA, USA

    Howard I. Maibach

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Ali, A.A.A., Marzano, A.V., Alavi, A. (2020). Wound Healing in Pyoderma Gangrenosum. In: Alavi, A., Maibach, H. (eds) Local Wound Care for Dermatologists. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-28872-3_19

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  • DOI: https://doi.org/10.1007/978-3-030-28872-3_19

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