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Cellular- and Acellular-Based Therapies: Skin Substitutes and Matrices

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Local Wound Care for Dermatologists

Part of the book series: Updates in Clinical Dermatology ((UCD))

Abstract

Recalcitrant wounds pose a challenge to the dermatologist. In recent years, many skin substitutes have been developed and are broadly classified as either acellular or cellular. These skin substitutes are to be used in concert with standard of care to provide the stalled wound with a scaffold and key elements such as cytokines, growth factors, and extracellular matrix substances. Skin substitutes help initiate and accelerate wound healing through granulation, cell migration, re-vascularization, and re-epithelialization. Wounds of varying etiologies have been shown to benefit from the multitude of acellular and cellular skin substitutes that are available. This chapter provides clinically relevant background and practical guidance about skin substitutes to allow dermatologists to effectively incorporate these powerful tools into their wound healing armamentarium.

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Abbreviations

BLCCs:

Bilayered living cellular constructs

CA:

Cadaveric allograft

CDM:

Collagen dermal matrix

CEAs:

Cultured epidermal autografts

CPM:

Cryopreserved placental membrane

DFU:

Diabetic foot ulcer

DHACM:

Dehydrated human amnion/chorion membrane

DRT:

Dermal regeneration template

ECM:

Extracellular matrix

PU:

Pressure ulcer

VLU:

Venous leg ulcer

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Authors and Affiliations

  1. Albert Einstein College of Medicine, Bronx, NY, USA

    Brian Cahn

  2. Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA

    Hadar Lev-Tov

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  1. Brian Cahn
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  2. Hadar Lev-Tov
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Correspondence to Brian Cahn .

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Editors and Affiliations

  1. Division of Dermatology, Department of Medicine, Women’s College Hospital, University of Toronto, Toronto, ON, Canada

    Afsaneh Alavi

  2. Department of Dermatology, University of San Francisco, San Francisco, CA, USA

    Howard I. Maibach

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Cahn, B., Lev-Tov, H. (2020). Cellular- and Acellular-Based Therapies: Skin Substitutes and Matrices. In: Alavi, A., Maibach, H. (eds) Local Wound Care for Dermatologists. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-28872-3_15

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  • DOI: https://doi.org/10.1007/978-3-030-28872-3_15

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  • Online ISBN: 978-3-030-28872-3

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