Skip to main content
SpringerLink
Log in

Endometriosis, Infertility, and Oocyte Quality

  • Chapter
  • First Online:
Pick Up and Oocyte Management

Abstract

Endometriosis is a gynecological disease characterized by the presence of endometrial glandular and stromal cells existing in the extra-uterine environment. Estimates show that endometriosis affects 10–15% of all women of reproductive age. Approximately, 25–50% of infertile women may be affected by endometriosis and 30–50% patients with endometriosis may suffer from infertility. Several mechanisms have been proposed for the association of endometriosis and infertility, including distorted pelvic anatomy, impaired ovary function, altered microenvironment, affected endometrial receptivity, and reduced oocyte/embryo quality. Patients with endometriosis have inflammatory processes within the increased amount of peritoneal fluid noted. These inflammatory processes and hormonal changes have shown to alter folliculogenesis, sperm motility, tubal transport, and embryo implantation.

Oocyte quality is an important factor in the success of assisted reproductive technology treatment, and the environment of follicle growth has a significant influence on this quality. It is very difficult, however, to directly evaluate oocyte quality. Follicular fluid (FF), however, might reflect the environment during follicle and oocyte growth. Therefore, an evaluation of oxidative stress in the FF might be useful in predicting oocyte quality.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

ART:

Assisted reproductive technique

COH:

Controlled ovarian hyperstimulation

COS:

Controlled ovarian stimulation

COX-2–PGE2:

Cyclooxygenase-2 prostaglandin-2

FF:

Follicular fluid

GM-CSF:

Granulocyte macrophage-colony stimulator factor

GPx:

Glutathione peroxidase

GR:

Glutathione reductase

ICSI:

Intracytoplasmatic sperm injection

IFN-α:

Interferon-α

IL-1:

Interleukin-1

IL-12:

Interleukin-12

IL-2:

Interleukin-2

IL-4:

Interleukin-4

IL-6:

Interleukin-6

IL-8:

Interleukin-8

IVF:

In vitro fertilization

LPO:

Lipid peroxidation

MCP-1:

Monocyte chemotactic protein-1

MCs:

Mast cells

MMPs:

Matrix metalloproteinases

NK:

Natural Killer

NO:

Nitric oxide

OFF:

Ovarian follicular fluid

OS:

Oxidative stress

PCR:

Polymerase chain reaction

PDGF:

Platelet-derived growth factor

PF:

Peritoneal fluid

PG:

Prostaglandin

PP:

Peripheral plasma

ROL:

Retinol

ROS:

Reactive oxygen species

SOD:

Superoxide dismutase

SOD1:

Superoxide dismutase 1

TAC:

Total antioxidant capacity

TEM:

Transmission electron microscopy

TGF-β:

Transforming growth factor-β

TNF-α:

Tumor necrosis factor-α

VEGF:

Vascular endothelial growth factor 3

References

  1. Hirsch M, Begum MR, Paniz É, Barker C, Davis CJ, Duffy J. Diagnosis and management of endometriosis: a systematic review of international and national guidelines. BJOG. 2018;125(5):556–64.

    CAS  PubMed  Google Scholar 

  2. Cho YJ, Lee SH, Park JW, Han M, Park MJ, Han SJ. Dysfunctional signaling underlying endometriosis: current state of knowledge. J Mol Endocrinol. 2018;60(3):R97–R113.

    CAS  PubMed  Google Scholar 

  3. Patel BG, Lenk EE, Lebovic DI, Shu Y, Yu J, Taylor RN. Pathogenesis of endometriosis: interaction between endocrine and inflammatory pathways. Best Pract Res Clin Obstet Gynaecol. 2018;50:50–60. https://doi.org/10.1016/j.bpobgyn.2018.01.006. pii: S1521-6934(18)30023-3.

    Article  PubMed  Google Scholar 

  4. Clemenza S, Sorbi F, Noci I, Capezzuoli T, Turrini I, Carriero C, Buffi N, Fambrini M, Petraglia F. From pathogenesis to clinical practice: emerging medical treatments for endometriosis. Best Pract Res Clin Obstet Gynaecol. 2018;51:92–101. https://doi.org/10.1016/j.bpobgyn.2018.01.021. pii: S1521-6934(18)30039-7.

    Article  PubMed  Google Scholar 

  5. Greene AD, Lang SA, Kendziorski JA, Sroga-Rios JM, Herzog TJ, Burns KA. Endometriosis: where are we and where are we going? Reproduction. 2016;152(3):R63–78. https://doi.org/10.1530/REP-16-0052.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Donnez J, Donnez O, Orellana R, Binda MM, Dolmans MM. Endometriosis and infertility. Panminerva Med. 2016;58(2):143–50.

    PubMed  Google Scholar 

  7. Matalliotakis M, Zervou MI, Matalliotaki C, Rahmioglu N, Koumantakis G, Kalogiannidis I, Prapas I, Zondervan K, Spandidos DA, Matalliotakis I, Goulielmos GN. The role of gene polymorphisms in endometriosis. Mol Med Rep. 2017;16(5):5881–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Hughes EG, Fedorkow DM, Collins JA. A quantitative overview of controlled trials in endometriosis-associated infertility. Fertil Steril. 1993;59(5):963–70.

    CAS  PubMed  Google Scholar 

  9. Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization. Fertil Steril. 2002;77:1148–55.

    PubMed  Google Scholar 

  10. Giudice LC, Kao LC. Endometriosis. Lancet. 2004;364(9447):1789–99.

    PubMed  Google Scholar 

  11. Opoien HK, Fedorcsak P, Omland AK, Abyholm T, Bjercke S, Ertzeid G, Oldereid N, Mellembakken JR, Tanbo T. In vitro fertilization is a successful treatment in endometriosis-associated infertility. Fertil Steril. 2012;97:912–8.

    PubMed  Google Scholar 

  12. Lin XN, Wei ML, Tong XM, Xu WH, Zhou F, Huang QX, Wen GF, Zhang SY. Outcome of in vitro fertilization in endometriosis-associated infertility: a 5-year database cohort study. Chin Med J (Engl). 2012;125:2688–93.

    CAS  Google Scholar 

  13. Dong X, Liao X, Wang R, Zhang H. The impact of endometriosis on IVF/ICSI outcomes. Int J Clin Exp Pathol. 2013;6(9):1911–8.

    PubMed  PubMed Central  Google Scholar 

  14. Barbosa MA, Teixeira DM, Navarro PA, Ferriani RA, Nastri CO, Martins WP. Impact of endometriosis and its staging on assisted reproduction outcome: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2014;44(3):261–78.

    CAS  PubMed  Google Scholar 

  15. Tanbo T, Fedorcsak P. Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options. Acta Obstet Gynecol Scand. 2017;96(6):659–67.

    PubMed  Google Scholar 

  16. Jeung I, Cheon K, Kim MR. Decreased cytotoxicity of peripheral and peritoneal natural killer cell in endometriosis. Biomed Res Int. 2016;2016:2916070.

    PubMed  PubMed Central  Google Scholar 

  17. D’Hooghe TM, Debrock S, Hill JA, Meuleman C. Endometriosis and subfertility: is the relationship resolved? Semin Reprod Med. 2003;21(2):243–54.

    PubMed  Google Scholar 

  18. Khan KN, Kitajima M, Hiraki K, Fujishita A, Sekine I, Ishimaru T, Masuzaki H. Immunopathogenesis of pelvic endometriosis: role of hepatocyte growth factor, macrophages and ovarian steroids. Am J Reprod Immunol. 2008;60(5):383–404.

    CAS  PubMed  Google Scholar 

  19. Oosterlynck DJ, Cornillie FJ, Waer M, Vandeputte M, Koninckx PR. Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. Fertil Steril. 1991;56(1):45–51.

    CAS  PubMed  Google Scholar 

  20. Oosterlynck DJ, Meuleman C, Waer M, Vandeputte M, Koninckx PR. The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis. Fertil Steril. 1992;58(2):290–5.

    CAS  PubMed  Google Scholar 

  21. Bulletti C, Coccia ME, Battistoni S, Borini A. Endometriosis and infertility. J Assist Reprod Genet. 2010;27(8):441–7.

    PubMed  PubMed Central  Google Scholar 

  22. Garrido N, Navarro J, Remohí J, Simón C, Pellicer A. Follicular hormonal environment and embryo quality in women with endometriosis. Hum Reprod Update. 2000;6(1):67–74.

    CAS  PubMed  Google Scholar 

  23. Da Broi MG, Navarro PA. Oxidative stress and oocyte quality: ethiopathogenic mechanisms of minimal/mild endometriosis-related infertility. Cell Tissue Res. 2016;364(1):1–7.

    PubMed  Google Scholar 

  24. Sanchez AM, Vanni VS, Bartiromo L, Papaleo E, Zilberberg E, Candiani M, Orvieto R, Viganò P. Is the oocyte quality affected by endometriosis? A review of the literature. J Ovarian Res. 2017;10(1):43.

    PubMed  PubMed Central  Google Scholar 

  25. Stilley JA, Birt JA, Sharpe-Timms KL. Cellular and molecular basis for endometriosis-associated infertility. Cell Tissue Res. 2012;349(3):849–62.

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Miller JE, Ahn SH, Monsanto SP, Khalaj K, Koti M, Tayade C. Implications of immune dysfunction on endometriosis associated infertility. Oncotarget. 2017;8(4):7138–47.

    PubMed  Google Scholar 

  27. Prasad S, Tiwari M, Pandey AN, Shrivastav TG, Chaube SK. Impact of stress on oocyte quality and reproductive outcome. J Biomed Sci. 2016;23:36.

    PubMed  PubMed Central  Google Scholar 

  28. Missmer SA, Chavarro JE, Malspeis S, Bertone-Johnson ER, Hornstein MD, Spiegelman D, Barbieri RL, Willett WC, Hankinson SE. A prospective study of dietary fat consumption and endometriosis risk. Hum Reprod. 2010;25(6):1528–35.

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Hauzman EE, Garcia-Velasco JA, Pellicer A. Oocyte donation and endometriosis: what are the lessons? Semin Reprod Med. 2013;31(2):173–7.

    PubMed  Google Scholar 

  30. Afshar Y, Hastings J, Roqueiro D, Jeong JW, Giudice LC, Fazleabas AT. Changes in eutopic endometrial gene expression during the progression of experimental endometriosis in the baboon, Papio anubis. Biol Reprod. 2013;88(2):44.

    PubMed  PubMed Central  Google Scholar 

  31. Bulun SE, Monsivais D, Kakinuma T, Furukawa Y, Bernardi L, Pavone ME, Dyson M. Molecular biology of endometriosis: from aromatase to genomic abnormalities. Semin Reprod Med. 2015;33(3):220–4.

    CAS  PubMed  Google Scholar 

  32. Bulun SE. Endometriosis. N Engl J Med. 2009;360(3):268–79.

    CAS  PubMed  Google Scholar 

  33. Pavone ME, Dyson M, Reirstad S, Pearson E, Ishikawa H, Cheng YH, Bulun SE. Endometriosis expresses a molecular pattern consistent with decreased retinoid uptake, metabolism and action. Hum Reprod. 2011;26(8):2157–64.

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Chen GY, Nuñez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010;10(12):826–37.

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Haney AF, Muscato JJ, Weinberg JB. Peritoneal fluid cell populations in infertility patients. Fertil Steril. 1981;35(6):696–8.

    CAS  PubMed  Google Scholar 

  36. Beste MT, Pfäffle-Doyle N, Prentice EA, Morris SN, Lauffenburger DA, Isaacson KB, Griffith LG. Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation. Sci Transl Med. 2014;6(222):222ra16.

    PubMed  PubMed Central  Google Scholar 

  37. Osborn BH, Haney AF, Misukonis MA, Weinberg JB. Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility. Fertil Steril. 2002;77(1):46–51.

    PubMed  Google Scholar 

  38. Goud AP, Goud PT, Diamond MP, Gonik B, Abu-Soud HM. Activation of the cGMP signaling pathway is essential in delaying oocyte aging in diabetes mellitus. Biochemistry. 2006;45(38):11366–78.

    CAS  PubMed  Google Scholar 

  39. Somigliana E, Viganò P, Gaffuri B, Candiani M, Busacca M, Di Blasio AM, Vignali M. Modulation of NK cell lytic function by endometrial secretory factors: potential role in endometriosis. Am J Reprod Immunol. 1996;36(5):295–300.

    CAS  PubMed  Google Scholar 

  40. Kokcu A. Possible effects of endometriosis-related immune events on reproductive function. Arch Gynecol Obstet. 2013;287(6):1225–33.

    CAS  PubMed  Google Scholar 

  41. Heitmann RJ, Tobler KJ, Gillette L, Tercero J, Burney RO. Dexamethasone attenuates the embryotoxic effect of endometriotic peritoneal fluid in a murine model. J Assist Reprod Genet. 2015;32(9):1317–23.

    PubMed  PubMed Central  Google Scholar 

  42. Riccio LDGC, Santulli P, Marcellin L, Abrão MS, Batteux F, Chapron C. Immunology of endometriosis. Best Pract Res Clin Obstet Gynaecol. 2018;50:39–49. https://doi.org/10.1016/j.bpobgyn.2018.01.010. pii: S1521-6934(18)30028-2.

    Article  PubMed  Google Scholar 

  43. Harris SE, Faddy M, Levett S, et al. Analysis of donor heterogeneity as a factor affecting the clinical outcome of oocyte donation. Hum Fertil (Camb). 2002;5:193–8.

    Google Scholar 

  44. Wang Q, Sun QY. Evaluation of oocyte quality: morphological, cellular and molecular predictors. Reprod Fertil Dev. 2007;19:1–12.

    PubMed  Google Scholar 

  45. Cohen Y, Malcov M, Schwartz T, Mey-Raz N, Carmon A, Cohen T, et al. Spindle imaging: a new marker for optimal timing of ICSI? Hum Reprod. 2004;19:649–54.

    CAS  PubMed  Google Scholar 

  46. De Santis L, Cino I, Rabellotti E, Calzi F, Persico P, Borini A, et al. Polar body morphology and spindle imaging as predictors of oocyte quality. Reprod Biomed Online. 2005;11:36–42.

    PubMed  Google Scholar 

  47. Dmowski WP, Rana N, Michalowska J, Friberg J, Papierniak C, el-Roeiy A. The effect of endometriosis, its stage and activity, and of autoantibodies on in vitro fertilisation and embryo transfer success rates. Fertil Steril. 1995;63:555–62.

    CAS  PubMed  Google Scholar 

  48. Bergendal A, Naffah S, Nagy C, Bergqvist A, Sjöblom P, Hillensjö T. Outcome of IVF in patients with endometriosis in comparison with tubal factor infertility. J Assist Reprod Genet. 1998;15:530–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  49. Simón C, Gutiérrez A, Vidal A, de los Santos MJ, Tarín JJ, Remohí J, Pellicer A. Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod. 1994;9(4):725–9.

    PubMed  Google Scholar 

  50. Garrido N, Navarro J, Remohí J, Simón C, Pellicer A. Follicular hormonal environment and embryo quality in women with endometriosis. Hum Reprod Update. 2000;6(1):67–74.

    CAS  PubMed  Google Scholar 

  51. Garrido N, Navarro J, García-Velasco J, Remoh J, Pellice A, Simón C. The endometrium versus embryonic quality in endometriosis-related infertility. Hum Reprod Update. 2002;8(1):95–103.

    CAS  PubMed  Google Scholar 

  52. Hamdan M, Omar SZ, Dunselman G, Cheong Y. Influence of endometriosis on assisted reproductive technology outcomes: a systematic review and meta-analysis. Obstet Gynecol. 2015;125:79–88.

    PubMed  Google Scholar 

  53. Xu B, Guo N, Zhang XM, Shi W, Tong XH, Iqbal F, Liu YS. Oocyte quality is decreased in women with minimal or mild endometriosis. Sci Rep. 2015;5:10779.

    PubMed  PubMed Central  Google Scholar 

  54. Díaz-Fontdevila M, Pommer R, Smith R. Cumulus cell apoptosis changes with exposure to spermatozoa and pathologies involved in infertility. Fertil Steril. 2009;91(5 Suppl):2061–8.

    PubMed  Google Scholar 

  55. Wu R, Van der Hoek KH, Ryan NK, Norman RJ, Robker RL. Macrophage contributions to ovarian function. Hum Reprod Update. 2004;10(2):119–33.

    PubMed  Google Scholar 

  56. Brizek CL, Schlaff S, Pellegrini VA, Frank JB, Worrilow KC. Increased incidence of aberrant morphological phenotypes in human embryogenesis—an association with endometriosis. J Assist Reprod Genet. 1995;12(2):106–12.

    CAS  PubMed  Google Scholar 

  57. Garrido N, Pellicer A, Remohí J, Simón C. Uterine and ovarian function in endometriosis. Semin Reprod Med. 2003;21(2):183–92.

    CAS  PubMed  Google Scholar 

  58. Kimura F, Takahashi K, Takebayashi K, Fujiwara M, Kita N, Noda Y, Harada N, et al. Fertil Steril. 2007;87(6):1468.e9–12.

    Google Scholar 

  59. Burney RO, Talbi S, Hamilton AE, et al. Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis. Endocrinology. 2007;48:3814–26.

    Google Scholar 

  60. Kao LC, Germeyer A, Tulac S, et al. Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology. 2003;144:2870–81.

    CAS  PubMed  Google Scholar 

  61. Kemmann E, Ghazi D, Corsan G, et al. Does ovulation stimulation improve fertility in women with minimal/mild endometriosis after laser laparoscopy? Int J Fertil Menopausal Stud. 1993;38:16–21.

    CAS  PubMed  Google Scholar 

  62. Evans MB, Decherney AH. Fertility and endometriosis. Clin Obstet Gynecol. 2017;60(3):497–502.

    PubMed  Google Scholar 

  63. Wunder DM, Mueller MD, Birkhäuser MH, Bersinger NA. Steroids and protein markers in the follicular fluid as indicators of oocyte quality in patients with and without endometriosis. J Assist Reprod Genet. 2005;22(6):257–64.

    PubMed  PubMed Central  Google Scholar 

  64. von Wolff M, Kollmann Z, Flück CE, Stute P, Marti U, Weiss B, et al. Gonadotrophin stimulation for in vitro fertilization significantly alters the hormone milieu in follicular fluid: a comparative study between natural cycle IVF and conventional IVF. Hum Reprod. 2014;29:1049–57.

    Google Scholar 

  65. Härkki P, Tiitinen A, Ylikorkala O. Endometriosis and assisted reproduction techniques. Ann N Y Acad Sci. 2010;1205:207–13.

    PubMed  Google Scholar 

  66. Gupta S, Agarwal A, Krajcir N, Alvarez JG. Role of oxidative stress in endometriosis. Reprod Biomed Online. 2006;13(1):126–34.

    CAS  PubMed  Google Scholar 

  67. Agarwal A, Said TM, Bedaiwy MA, Banerjee J, Alvarez JG. Oxidative stress in an assisted reproductive techniques setting. Fertil Steril. 2006;86(3):503–12.

    CAS  PubMed  Google Scholar 

  68. Navarro PA, Liu L, Ferriani RA, Keefe DL. Arsenite induces aberrations in meiosis that can be prevented by coadministration of N-acetylcysteine in mice. Fertil Steril. 2006;85(Suppl 1):1187–94.

    CAS  PubMed  Google Scholar 

  69. Prieto L, Quesada JF, Cambero O, et al. Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis. Fertil Steril. 2012;98(1):126–30.

    CAS  PubMed  Google Scholar 

  70. Donabela FC, Meola J, Padovan CC, de Paz CC, Navarro PA. Higher SOD1 gene expression in cumulus cells from infertile women with moderate and severe endometriosis. Reprod Sci. 2015;22(11):1452–60.

    CAS  PubMed  Google Scholar 

  71. Singh AK, Chattopadhyay R, Chakravarty B, Chaudhury K. Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF. Reprod Toxicol. 2013;42:116–24.

    CAS  PubMed  Google Scholar 

  72. Saito H, Seino T, Kaneko T, Nakahara K, Toya M, Kurachi H. Endometriosis and oocyte quality. Gynecol Obstet Invest. 2002;53(Suppl 1):46–51.

    PubMed  Google Scholar 

  73. Turkyilmaz E, Yildirim M, Cendek BD, Baran P, Alisik M, Dalgaci F, Yavuz AF. Evaluation of oxidative stress markers and intra-extracellular antioxidant activities in patients with endometriosis. Eur J Obstet Gynecol Reprod Biol. 2016;199:164–8.

    CAS  PubMed  Google Scholar 

  74. Wunder DM, Mueller MD, Birkhäuser MH, Bersinger NA. Increased ENA-78 in the follicular fluid of patients with endometriosis. Acta Obstet Gynecol Scand. 2006;85(3):336–42.

    CAS  PubMed  Google Scholar 

  75. Da Broi MG, Malvezzi H, Paz CC, Ferriani RA, Navarro PA. Follicular fluid from infertile women with mild endometriosis may compromise the meiotic spindles of bovine metaphase II oocytes. Hum Reprod. 2014;29(2):315–23.

    PubMed  Google Scholar 

  76. Da Broi MG, de Albuquerque FO, de Andrade AZ, Cardoso RL, Jordão Junior AA, Navarro PA. Increased concentration of 8-hydroxy-2′-deoxyguanosine in follicular fluid of infertile women with endometriosis. Cell Tissue Res. 2016;366(1):231–42.

    PubMed  Google Scholar 

  77. Baumann C, Olson M, Wang K, Fazleabas A, De La Fuente R. Arginine methyltransferases mediate an epigenetic ovarian response to endometriosis. Reproduction. 2015;150(4):297–310.

    CAS  PubMed  Google Scholar 

  78. Kasapoglu I, Kuspinar G, Saribal S, Turk P, Avcı B, Uncu G. Detrimental effects of endometriosis on oocyte morphology in intracytoplasmic sperm injection cycles: a retrospective cohort study. Gynecol Endocrinol. 2018;34(3):206–211.11.

    PubMed  Google Scholar 

  79. Santonastaso M, Pucciarelli A, Costantini S, Caprio F, Sorice A, Capone F, Natella A, Iardino P, Colacurci N, Chiosi E. Metabolomic profiling and biochemical evaluation of the follicular fluid of endometriosis patients. Mol Biosyst. 2017;13(6):1213–22.

    Google Scholar 

  80. Shebl O, Sifferlinger I, Habelsberger A, Oppelt P, Mayer RB, Petek E, Ebner T. Oocyte competence in in vitro fertilization and intracytoplasmic sperm injection patients suffering from endometriosis and its possible association with subsequent treatment outcome: a matched case-control study. Acta Obstet Gynecol Scand. 2017;96(6):736–44.

    CAS  PubMed  Google Scholar 

  81. Nakagawa K, Hisano M, Sugiyama R, Yamaguchi K. Measurement of oxidative stress in the follicular fluid of infertility patients with an endometrioma. Arch Gynecol Obstet. 2016;293(1):197–202.

    CAS  PubMed  Google Scholar 

  82. Nasiri N, Moini A, Eftekhari-Yazdi P, Karimian L, Salman-Yazdi R, Arabipoor A. Oxidative stress statues in serum and follicular fluid of women with endometriosis. Cell J. 2017;18(4):582–7.

    PubMed  Google Scholar 

  83. da Luz CM, da Broi MG, Donabela FC, Paro de Paz CC, Meola J, Navarro PA. PTGS2 down-regulation in cumulus cells of infertile women with endometriosis. Reprod Biomed Online. 2017;35(4):379–86.

    PubMed  Google Scholar 

  84. Pauli SA, Session DR, Shang W, Easley K, Wieser F, Taylor RN, Pierzchalski K, Napoli JL, Kane MA, Sidell N. Analysis of follicular fluid retinoids in women undergoing in vitro fertilization: retinoic acid influences embryo quality and is reduced in women with endometriosis. Reprod Sci. 2013;20(9):1116–24.

    PubMed  PubMed Central  Google Scholar 

  85. Du YB, Gao MZ, Shi Y, Sun ZG, Wang J. Endocrine and inflammatory factors and endometriosis-associated infertility in assisted reproduction techniques. Arch Gynecol Obstet. 2013;287(1):123–30.

    CAS  PubMed  Google Scholar 

  86. Hwu YM, Wu FS-Y, Li S-H, Sun F-J, Lin M-H, Lee RK-K. The impact of endometrioma and laparoscopic cystectomy on serum anti-Mullerian hormone levels. Reprod Biol Endocrinol. 2011;9:80.

    CAS  PubMed  PubMed Central  Google Scholar 

  87. Busacca M, Riparini J, Somigliana E, Oggioni G, Izzo S, Vignali M, et al. Postsurgical ovarian failure after laparoscopic excision of bilateral endometriomas. Am J Obstet Gynecol. 2006;195(2):421–5.

    PubMed  Google Scholar 

  88. Coccia ME, Rizzello F, Mariani G, Bulletti C, Palagiano A, Scarselli G. Ovarian surgery for bilateral endometriomas influences age at menopause. Hum Reprod. 2011;26(11):3000–7.

    PubMed  Google Scholar 

  89. Roman H, Tarta O, Pura I, Opris I, Bourdel N, Marpeau L, et al. Direct proportional relationship between endometrioma size and ovarian parenchyma inadvertently removed during cystectomy, and its implication on the management of enlarged endometriomas. Hum Reprod. 2010;25:1428–32.

    PubMed  Google Scholar 

  90. Li CZ, Liu B, Wen ZQ, Sun Q. The impact of electrocoagulation on ovarian reserve after laparoscopic excision of ovarian cyst: a prospective clinical study of 191 patients. Fertil Steril. 2009;92:1428–35.

    PubMed  Google Scholar 

  91. Romualdi D, Franco Zannoni G, Lanzone A, Selvaggi L, Tagliaferri V, Gaetano Vellone V, et al. Follicular loss in endoscopic surgery for ovarian endometriosis: quantitative and qualitative observations. Fertil Steril. 2011;96(2):374–8.

    PubMed  Google Scholar 

  92. Tandoi I, Somigliana E, Riparini J, Ronzoni S, Vigano P, Candiani M. High rate of endometriosis recurrence in young women. J Pediatr Adolesc Gynecol. 2011;24(6):376–9.

    PubMed  Google Scholar 

  93. Hirokawa W, Iwase A, Goto M, Takikawa S, Nagatomo Y, Nakahara T, et al. The post-operative decline in serum anti-Mullerian hormone correlates with the bilaterality and severity of endometriosis. Hum Reprod. 2011;26(4):904–10.

    CAS  PubMed  Google Scholar 

  94. Tanbo T, Henriksen T, Magnus O, Abyholm T. Oocyte retrieval in an IVF program. A comparison of laparoscopic and transvaginal ultrasound-guided follicular puncture. Acta Obstet Gynecol Scand. 1988;67(3):243–6.

    CAS  PubMed  Google Scholar 

  95. Ota Y, Andou M, Ota I. Laparoscopic surgery with urinary tract reconstruction and bowel endometriosis resection for deep infiltrating endometriosis. Asian J Endosc Surg. 2018;11(1):7–14.

    PubMed  Google Scholar 

  96. King CR, Lum D. Techniques in minimally invasive surgery for advanced endometriosis. Curr Opin Obstet Gynecol. 2016;28(4):316–22.

    PubMed  Google Scholar 

  97. Khine YM, Taniguchi F, Harada T. Clinical management of endometriosis-associated infertility. Reprod Med Biol. 2016;15(4):217–25.

    PubMed  PubMed Central  Google Scholar 

  98. Nezhat F, Nezhat C, Allan CJ, Metzger DA, Sears DL. Clinical and histologic classification of endometriomas: implications for a mechanism of pathogenesis. J Reprod Med. 1992;37(9):771–6.

    CAS  PubMed  Google Scholar 

  99. Vigano P, Vanni VS, Corti L, Garavaglia E, Tandoi I, Pagliardini L, et al. Unravelling the ovarian endometrioma pathogenesis: “the long and winding road across the various theories.”. J Endometr Pelvic Pain Disord. 2013;5:62–7.

    Google Scholar 

  100. Gerard N, Caillaud M, Martoriati A, Goudet G, Lalmanach AC. The interleukin-1 system and female reproduction. J Endocrinol. 2004;180:203–12.

    CAS  PubMed  Google Scholar 

  101. Somigliana E, Vigano P, Benaglia L, Busnelli A, Vercellini P, Fedele L. Adhesion prevention in endometriosis: a neglected critical challenge. J Minim Invasive Gynecol. 2012;19:415–21.

    PubMed  Google Scholar 

  102. Nezhat C, Nezhat F, Nezhat CH, Seidman DS. Classification of endometriosis: improving the classification of endometriotic ovarian cysts. Hum Reprod. 1994;9(12):2212–3.

    CAS  PubMed  Google Scholar 

  103. Nezhat C, Nezhat F, Nezhat CH. Nezhat’s video-assisted and robotic-assisted laparoscopy and hysteroscopy. 4th ed. New York: Cambridge University Press; 2013.

    Google Scholar 

  104. Benaglia L, Busnelli A, Biancardi R, Vegetti W, Reschini M, Vercellini P, Somigliana E. Oocyte retrieval difficulties in women with ovarian endometriomas. Reprod Biomed Online. 2018;37(1):77–84.

    PubMed  Google Scholar 

  105. Somigliana E, Vigano P, Filippi F, Papaleo E, Benaglia L, Candiani M, et al. Fertility preservation in women with endometriosis: for all, for some, for none? Hum Reprod. 2015;20:1280–6.

    Google Scholar 

  106. Cecchino GN, Garcia-Velasco JA. Endometrioma, fertility, and assisted reproductive treatments: connecting the dots. Curr Opin Obstet Gynecol. 2018;30(4):223–8.

    PubMed  Google Scholar 

  107. Littman E, Giudice L, Lathi R, Berker B, Milki A, Nezhat C. Role of laparoscopic treatment of endometriosis in patients with failed in vitro fertilization cycles. Fertil Steril. 2005;84(6):1574–8.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Experimental Endoscopic Surgery, Imaging, Technology and Minimally Invasive Therapy, Department of Obstetrics and Gynecology, Vito Fazzi Hospital, Lecce, Italy

    Andrea Tinelli

  2. Laboratory of Human Physiology, Phystech BioMed School, Faculty of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia

    Andrea Tinelli, Ospan A. Mynbaev, Ioannis P. Kosmas, Renata Beck & Antonio Malvasi

  3. Minimally Invasive Surgery Fellowship Program, Nezhat Medical Center, Atlanta, GA, USA

    Ceana H. Nezhat

  4. Training and Education Program, and Minimally Invasive Surgery and Robotics, Northside Hospital, Atlanta, GA, USA

    Ceana H. Nezhat

  5. Department of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, GA, USA

    Ceana H. Nezhat

  6. Society of Reproductive Surgeons, Birmingham, AL, USA

    Ceana H. Nezhat

  7. Department of Obstetrics and Gynecology, Weill Cornell Medical College of Cornell University, NewYork, NY, USA

    Farr R. Nezhat

  8. Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, NYU-Winthrop University Hospital, State University of New York at Stony Brook, College of Medicine, NewYork, NY, USA

    Farr R. Nezhat

  9. Division of Molecular Technologies, Research Institute of Translational Medicine, N. I. Pirogov Russian National Research Medical University, Moscow, Russia

    Ospan A. Mynbaev

  10. Institute of Numerical Mathematics, RAS, Moscow, Russia

    Ospan A. Mynbaev

  11. Clinic of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia

    Radmila Sparic

  12. School of Medicine, University of Belgrade, Belgrade, Serbia

    Radmila Sparic

  13. Department of Obstetrics and Gynecology, Ioannina State General Hospital G. Hatzikosta, Ioannina, Greece

    Ioannis P. Kosmas & Renata Beck

  14. Department of Obstetrics and Gynecology, GVM Care and Research Santa Maria Hospital, Bari, Italy

    Antonio Malvasi

Authors
  1. Andrea Tinelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ceana H. Nezhat
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Farr R. Nezhat
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ospan A. Mynbaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Radmila Sparic
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ioannis P. Kosmas
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Renata Beck
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Antonio Malvasi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Santa Maria Hospital, GVM Care and Research, Bari, Italy

    Antonio Malvasi

  2. Center of Medically Assisted Procreation, MOMO’ fertiLIFE Srl, Bisceglie, Italy

    Domenico Baldini

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Tinelli, A. et al. (2020). Endometriosis, Infertility, and Oocyte Quality. In: Malvasi, A., Baldini, D. (eds) Pick Up and Oocyte Management. Springer, Cham. https://doi.org/10.1007/978-3-030-28741-2_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-28741-2_17

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-28740-5

  • Online ISBN: 978-3-030-28741-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation