Skip to main content

Ventricular Ectopic Ablation

  • Chapter
  • First Online:
Decoding Cardiac Electrophysiology

Abstract

Ventricular ectopics (VEs) also called premature ventricular contractions (PVCs) can be present in individuals with and without structural heart disease. Symptoms and prognosis vary greatly. The ECG is the cornerstone of diagnostic evaluation defining the origin as well as PVC burden. Even in structurally normal hearts PVCs can lead to PVC-induced cardiomyopathy. In structural heart disease, PVCs can aggravate left ventricular dysfunction. Indications for catheter ablation of PVCs include symptomatic PVCs, PVC-induced cardiomyopathy, malignant PVCs triggering ventricular tachyarrhythmia, reduced biventricular pacing in patients with cardiac resynchronization therapy and asymptomatic patients with a high PVC burden. Established mapping strategies are the “local earliest activation”, the unipolar electrogram, pace-mapping and 3D electroanatomical mapping systems. This chapter describes algorithms for identifying the PVC origin on an ECG, mapping strategies, and localization in structurally normal hearts and structural heart disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 64.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Duncker D, Bauersachs J, Veltmann C. Ventricular arrhythmias: what has been confirmed in therapy? Internist (Berl). 2017;58:1272–80.

    Article  CAS  Google Scholar 

  2. Kostis JB, McCrone K, Moreyra AE, Gotzoyannis S, Aglitz NM, Natarajan N, Kuo PT. Premature ventricular complexes in the absence of identifiable heart disease. Circulation. 1981;63:1351–6.

    Article  CAS  PubMed  Google Scholar 

  3. Brugada P, Gürsoy S, Brugada J, Andries E. Investigation of palpitations. Lancet. 1993;341:1254–8.

    Article  CAS  PubMed  Google Scholar 

  4. Singh SM, Kadmon E, Suszko A, Chauhan VS. Syncope triggered by a premature ventricular complex: a case of atrial fibrillation and paroxysmal atrioventricular block. Heart Rhythm. 2012;9:1650–1.

    Article  PubMed  Google Scholar 

  5. Latchamsetty R, Yokokawa M, Morady F, et al. Multicenter outcomes for catheter ablation of idiopathic premature ventricular complexes. JACC: Clin Electrophysiol. 2015;1:116–23.

    Google Scholar 

  6. Pedersen CT, Kay GN, Kalman J, et al. EHRA/HRS/APHRS expert consensus on ventricular arrhythmias. Europace. 2014;16:1257–83.

    Article  PubMed  Google Scholar 

  7. Arnar DO, Mairesse GH, Boriani G, et al. Management of asymptomatic arrhythmias: a European heart rhythm association (EHRA) consensus document, endorsed by the heart failure association (HFA), heart rhythm society (HRS), Asia Pacific heart rhythm society (APHRS), cardiac arrhythmia society of Southern Africa (CASSA), and Latin America heart rhythm society (LAHRS). Europace. 2019. https://doi.org/10.1093/europace/euz046.

  8. Ataklte F, Erqou S, Laukkanen J, Kaptoge S. Meta-analysis of ventricular premature complexes and their relation to cardiac mortality in general populations. Am J Cardiol. 2013;112:1263–70.

    Article  PubMed  Google Scholar 

  9. Dukes JW, Dewland TA, Vittinghoff E, et al. Ventricular ectopy as a predictor of heart failure and death. J Am Coll Cardiol. 2015;66:101–9.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Lee Y-H, Zhong L, Roger VL, Asirvatham SJ, Shen W-K, Slusser JP, Hodge DO, Cha Y-M. Frequency, origin, and outcome of ventricular premature complexes in patients with or without heart diseases. Am J Cardiol. 2014;114:1373–8.

    Article  PubMed  Google Scholar 

  11. Lee V, Hemingway H, Harb R, Crake T, Lambiase P. The prognostic significance of premature ventricular complexes in adults without clinically apparent heart disease: a meta-analysis and systematic review. Heart. 2012;98:1290–8.

    Article  PubMed  Google Scholar 

  12. Yarlagadda RK, Iwai S, Stein KM, Markowitz SM, Shah BK, Cheung JW, Tan V, Lerman BB, Mittal S. Reversal of cardiomyopathy in patients with repetitive monomorphic ventricular ectopy originating from the right ventricular outflow tract. Circulation. 2005;112:1092–7.

    Article  PubMed  Google Scholar 

  13. Sarrazin J-F, Labounty T, Kühne M, et al. Impact of radiofrequency ablation of frequent post-infarction premature ventricular complexes on left ventricular ejection fraction. Heart Rhythm. 2009;6:1543–9.

    Article  PubMed  PubMed Central  Google Scholar 

  14. El Kadri M, Yokokawa M, Labounty T, et al. Effect of ablation of frequent premature ventricular complexes on left ventricular function in patients with nonischemic cardiomyopathy. Heart Rhythm. 2015;12:706–13.

    Article  PubMed  Google Scholar 

  15. Bogun F, Crawford T, Reich S, et al. Radiofrequency ablation of frequent, idiopathic premature ventricular complexes: comparison with a control group without intervention. Heart Rhythm. 2007;4:863–7.

    Article  PubMed  Google Scholar 

  16. Ban J-E, Park H-C, Park J-S, Nagamoto Y, Choi JI, Lim HE, Park SW, Kim Y-H. Electrocardiographic and electrophysiological characteristics of premature ventricular complexes associated with left ventricular dysfunction in patients without structural heart disease. Europace. 2013;15:735–41.

    Article  PubMed  Google Scholar 

  17. Baman TS, Lange DC, Ilg KJ, et al. Relationship between burden of premature ventricular complexes and left ventricular function. Heart Rhythm. 2010;7:865–9.

    Article  PubMed  Google Scholar 

  18. Hasdemir C, Ulucan C, Yavuzgil O, et al. Tachycardia-induced cardiomyopathy in patients with idiopathic ventricular arrhythmias: the incidence, clinical and electrophysiologic characteristics, and the predictors. J Cardiovasc Electrophysiol. 2011;22:663–8.

    Article  PubMed  Google Scholar 

  19. Niwano S, Wakisaka Y, Niwano H, Fukaya H, Kurokawa S, Kiryu M, Hatakeyama Y, Izumi T. Prognostic significance of frequent premature ventricular contractions originating from the ventricular outflow tract in patients with normal left ventricular function. Heart. 2009;95:1230–7.

    Article  CAS  PubMed  Google Scholar 

  20. Carballeira Pol L, Deyell MW, Frankel DS, Benhayon D, Squara F, Chik W, Kohari M, Deo R, Marchlinski FE. Ventricular premature depolarization QRS duration as a new marker of risk for the development of ventricular premature depolarization-induced cardiomyopathy. Heart Rhythm. 2014;11:299–306.

    Article  PubMed  Google Scholar 

  21. Eiringhaus J, Hamer OW, Hollemann D, Brochhausen C, Vollmann D, Maier LS, Sossalla S. The detrimental potential of arrhythmia-induced cardiomyopathy. ESC Heart Fail. 2018;5:960–4.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Mullens W, Grimm RA, Verga T, Dresing T, Starling RC, Wilkoff BL, Tang WHW. Insights from a cardiac resynchronization optimization clinic as part of a heart failure disease management program. J Am Coll Cardiol. 2009;53:765–73.

    Article  PubMed  Google Scholar 

  23. Koplan BA, Kaplan AJ, Weiner S, Jones PW, Seth M, Christman SA. Heart failure decompensation and all-cause mortality in relation to percent biventricular pacing in patients with heart failure: is a goal of 100% biventricular pacing necessary? J Am Coll Cardiol. 2009;53:355–60.

    Article  PubMed  Google Scholar 

  24. Hayes DL, Boehmer JP, Day JD, Gilliam FR, Heidenreich PA, Seth M, Jones PW, Saxon LA. Cardiac resynchronization therapy and the relationship of percent biventricular pacing to symptoms and survival. Heart Rhythm. 2011;8:1469–75.

    Article  PubMed  Google Scholar 

  25. Lakkireddy D, Di Biase L, Ryschon K, et al. Radiofrequency ablation of premature ventricular ectopy improves the efficacy of cardiac resynchronization therapy in nonresponders. J Am Coll Cardiol. 2012;60:1531–9.

    Article  PubMed  Google Scholar 

  26. Viskin S, Lesh MD, Eldar M, Fish R, Setbon I, Laniado S, Belhassen B. Mode of onset of malignant ventricular arrhythmias in idiopathic ventricular fibrillation. J Cardiovasc Electrophysiol. 1997;8:1115–20.

    Article  CAS  PubMed  Google Scholar 

  27. Noda T, Shimizu W, Taguchi A, Aiba T, Satomi K, Suyama K, Kurita T, Aihara N, Kamakura S. Malignant entity of idiopathic ventricular fibrillation and polymorphic ventricular tachycardia initiated by premature extrasystoles originating from the right ventricular outflow tract. J Am Coll Cardiol. 2005;46:1288–94.

    Article  PubMed  Google Scholar 

  28. Viskin S, Rosso R, Rogowski O, Belhassen B. The “short-coupled” variant of right ventricular outflow ventricular tachycardia: a not-so-benign form of benign ventricular tachycardia? J Cardiovasc Electrophysiol. 2005;16:912–6.

    Article  PubMed  Google Scholar 

  29. Priori SG, Blomström-Lundqvist C, Mazzanti A, et al. 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the european society of cardiology (ESC) endorsed by: association for european paediatric and congenital cardiology (AEPC). Europace. 2015;17:1601–87.

    PubMed  Google Scholar 

  30. Knecht S, Sacher F, Wright M, et al. Long-term follow-up of idiopathic ventricular fibrillation ablation: a multicenter study. J Am Coll Cardiol. 2009;54:522–8.

    Article  PubMed  Google Scholar 

  31. Kindwall KE, Brown J, Josephson ME. Electrocardiographic criteria for ventricular tachycardia in wide complex left bundle branch block morphology tachycardias. Am J Cardiol. 1988;61:1279–83.

    Article  CAS  PubMed  Google Scholar 

  32. B Garner J, M Miller J. Wide complex tachycardia—ventricular tachycardia or not ventricular tachycardia, that remains the question. Arrhythm Electrophysiol Rev. 2013;2:23–9.

    Article  Google Scholar 

  33. Takemoto M, Yoshimura H, Ohba Y, Matsumoto Y, Yamamoto U, Mohri M, Yamamoto H, Origuchi H. Radiofrequency catheter ablation of premature ventricular complexes from right ventricular outflow tract improves left ventricular dilation and clinical status in patients without structural heart disease. J Am Coll Cardiol. 2005;45:1259–65.

    Article  PubMed  Google Scholar 

  34. Ruwald MH, Mittal S, Ruwald A-C, et al. Association between frequency of atrial and ventricular ectopic beats and biventricular pacing percentage and outcomes in patients with cardiac resynchronization therapy. J Am Coll Cardiol. 2014;64:971–81.

    Article  PubMed  Google Scholar 

  35. Priori SG, Blomström-Lundqvist C, Mazzanti A, et al. 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the european society of cardiology (ESC) endorsed by: association for european paediatric and congenital cardiology (AEPC). Eur Heart J. 2015;36:2793–867.

    Article  PubMed  Google Scholar 

  36. Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the american college of cardiology/american heart association task force on clinical practice guidelines and the heart rhythm society. J Am Coll Cardiol. 2017. https://doi.org/10.1016/j.jacc.2017.10.054.

    Article  PubMed  Google Scholar 

  37. Miller JM, Marchlinski FE, Buxton AE, Josephson ME. Relationship between the 12-lead electrocardiogram during ventricular tachycardia and endocardial site of origin in patients with coronary artery disease. Circulation. 1988;77:759–66.

    Article  CAS  PubMed  Google Scholar 

  38. Kuchar DL, Ruskin JN, Garan H. Electrocardiographic localization of the site of origin of ventricular tachycardia in patients with prior myocardial infarction. J Am Coll Cardiol. 1989;13:893–903.

    Article  CAS  PubMed  Google Scholar 

  39. Segal OR, Chow AWC, Wong T, Trevisi N, Lowe MD, Davies DW, Bella Della P, Packer DL, Peters NS. A novel algorithm for determining endocardial VT exit site from 12-lead surface ECG characteristics in human, infarct-related ventricular tachycardia. J Cardiovasc Electrophysiol. 2007;18:161–8.

    Article  PubMed  Google Scholar 

  40. Yamada T, Platonov M, McElderry HT, Kay GN. Left ventricular outflow tract tachycardia with preferential conduction and multiple exits. Circ: Arrhythmia Electrophysiol. 2008;1:140–2.

    Google Scholar 

  41. Kodra A, Skipitaris N, Mountantonakis S. A case of focal ventricular tachycardia with alternating endocardial and epicardial exits: utility of non-invasive mapping in predicting exits. Europace. 2019;21:580.

    Article  PubMed  Google Scholar 

  42. Martin R, Maury P, Bisceglia C, et al. Characteristics of scar-related ventricular tachycardia circuits using ultra-high-density mapping. Circ: Arrhythmia Electrophysiol. 2018;11:e006569.

    Google Scholar 

  43. Vallès E, Bazan V, Marchlinski FE. ECG criteria to identify epicardial ventricular tachycardia in nonischemic cardiomyopathy. Circ: Arrhythmia Electrophysiol. 2010;3:63–71.

    Google Scholar 

  44. Haqqani HM, Marchlinski FE. The surface electrocardiograph in ventricular arrhythmias: lessons in localisation. Heart Lung Circ. 2019;28:39–48.

    Article  PubMed  Google Scholar 

  45. Berruezo A, Mont L, Nava S, Chueca E, Bartholomay E, Brugada J. Electrocardiographic recognition of the epicardial origin of ventricular tachycardias. Circulation. 2004;109:1842–7.

    Article  PubMed  Google Scholar 

  46. Adams JC, Srivathsan K, Shen WK. Advances in management of premature ventricular contractions. J Interv Card Electrophysiol. 2012;35:137–49.

    Article  PubMed  Google Scholar 

  47. Ouyang F, Fotuhi P, Ho SY, et al. Repetitive monomorphic ventricular tachycardia originating from the aortic sinus cusp: electrocardiographic characterization for guiding catheter ablation. J Am Coll Cardiol. 2002;39:500–8.

    Article  PubMed  Google Scholar 

  48. Anter E, Frankel DS, Marchlinski FE, Dixit S. Effect of electrocardiographic lead placement on localization of outflow tract tachycardias. Heart Rhythm. 2012;9:697–703.

    Article  PubMed  Google Scholar 

  49. Kamakura S, Shimizu W, Matsuo K, Taguchi A, Suyama K, Kurita T, Aihara N, Ohe T, Shimomura K. Localization of optimal ablation site of idiopathic ventricular tachycardia from right and left ventricular outflow tract by body surface ECG. Circulation. 1998;98:1525–33.

    Article  CAS  PubMed  Google Scholar 

  50. Betensky BP, Park RE, Marchlinski FE, et al. The V(2) transition ratio: a new electrocardiographic criterion for distinguishing left from right ventricular outflow tract tachycardia origin. J Am Coll Cardiol. 2011;57:2255–62.

    Article  PubMed  Google Scholar 

  51. Yoshida N, Yamada T, McElderry HT, Inden Y, Shimano M, Murohara T, Kumar V, Doppalapudi H, Plumb VJ, Kay GN. A novel electrocardiographic criterion for differentiating a left from right ventricular outflow tract tachycardia origin: the V2S/V3R index. J Cardiovasc Electrophysiol. 2014;25:747–53.

    Article  PubMed  Google Scholar 

  52. Zhang F, Hamon D, Fang Z, Xu Y, Yang B, Ju W, Bradfield J, Shivkumar K, Chen M, Tung R. Value of a posterior electrocardiographic lead for localization of ventricular outflow tract arrhythmias: the V4/V8 ratio. JACC: Clin Electrophysiol. 2017;3:678–86.

    PubMed  Google Scholar 

  53. Ito S, Tada H, Naito S, Kurosaki K, Ueda M, Hoshizaki H, Miyamori I, Oshima S, Taniguchi K, Nogami A. Development and validation of an ecg algorithm for identifying the optimal ablation site for idiopathic ventricular outflow tract tachycardia. J Cardiovasc Electrophysiol. 2003;14:1280–6.

    Article  PubMed  Google Scholar 

  54. Yamada T, Doppalapudi H, McELDERRY HT, et al. Idiopathic ventricular arrhythmias originating from the papillary muscles in the left ventricle: prevalence, electrocardiographic and electrophysiological characteristics, and results of the radiofrequency catheter ablation. J Cardiovasc Electrophysiol. 2010;21:62–9.

    Article  PubMed  Google Scholar 

  55. Sadek MM, Benhayon D, Sureddi R, et al. Idiopathic ventricular arrhythmias originating from the moderator band: electrocardiographic characteristics and treatment by catheter ablation. Heart Rhythm. 2015;12:67–75.

    Article  PubMed  Google Scholar 

  56. Al’Aref SJ, Ip JE, Markowitz SM, Liu CF, Thomas G, Frenkel D, Panda NC, Weinsaft JW, Lerman BB, Cheung JW. Differentiation of papillary muscle from fascicular and mitral annular ventricular arrhythmias in patients with and without structural heart disease. Circ: Arrhythmia Electrophysiol. 2015;8:616–24.

    Google Scholar 

  57. Paraskevaidis S, Theofilogiannakos EK, Konstantinou DM, Mantziari L, Kefalidis C, Megarisiotou A, Sarafidou A, Styliadis I. Narrow QRS complex in idiopathic (fascicular) left ventricular tachycardia. Herz. 2015;40:147–9.

    Article  CAS  PubMed  Google Scholar 

  58. Akdeniz C, Gul EE, Celik N, Karacan M, Tuzcu V. Catheter ablation of idiopathic right ventricular arrhythmias in children with limited fluoroscopy. J Interv Card Electrophysiol. 2016;46:355–60.

    Article  PubMed  Google Scholar 

  59. Prystowsky EN, Padanilam BJ, Joshi S, Fogel RI. Ventricular arrhythmias in the absence of structural heart disease. J Am Coll Cardiol. 2012;59:1733–44.

    Article  PubMed  Google Scholar 

  60. Heeger C-H, Hayashi K, Kuck KH, Ouyang F. Catheter ablation of idiopathic ventricular arrhythmias arising from the cardiac outflow tracts–recent insights and techniques for the successful treatment of common and challenging cases. Circ J. 2016;80:1073–86.

    Article  PubMed  Google Scholar 

  61. Liao Z, Zhan X, Wu S, et al. Idiopathic ventricular arrhythmias originating from the pulmonary sinus cusp: prevalence, electrocardiographic/electrophysiological characteristics, and catheter ablation. J Am Coll Cardiol. 2015;66:2633–44.

    Article  PubMed  Google Scholar 

  62. Pathak RK, Ariyarathna N, Garcia FC, Sanders P, Marchlinski FE. Catheter ablation of idiopathic ventricular arrhythmias. Heart Lung Circ. 2019;28:102–9.

    Article  PubMed  Google Scholar 

  63. Hachiya H, Aonuma K, Yamauchi Y, Igawa M, Nogami A, Iesaka Y. How to diagnose, locate, and ablate coronary cusp ventricular tachycardia. J Cardiovasc Electrophysiol. 2002;13:551–6.

    Article  PubMed  Google Scholar 

  64. Yamada T, McElderry HT, Doppalapudi H, et al. Idiopathic ventricular arrhythmias originating from the aortic root prevalence, electrocardiographic and electrophysiologic characteristics, and results of radiofrequency catheter ablation. J Am Coll Cardiol. 2008;52:139–47.

    Article  PubMed  Google Scholar 

  65. Jauregui Abularach ME, Campos B, Park K-M, et al. Ablation of ventricular arrhythmias arising near the anterior epicardial veins from the left sinus of valsalva region: ECG features, anatomic distance, and outcome. Heart Rhythm. 2012;9:865–73.

    Article  PubMed  Google Scholar 

  66. Santangeli P, Marchlinski FE, Zado ES, et al. Percutaneous epicardial ablation of ventricular arrhythmias arising from the left ventricular summit: outcomes and electrocardiogram correlates of success. Circ: Arrhythmia Electrophysiol. 2015;8:337–43.

    Google Scholar 

  67. Good E, Desjardins B, Jongnarangsin K, Oral H, Chugh A, Ebinger M, Pelosi F, Morady F, Bogun F. Ventricular arrhythmias originating from a papillary muscle in patients without prior infarction: a comparison with fascicular arrhythmias. Heart Rhythm. 2008;5:1530–7.

    Article  PubMed  Google Scholar 

  68. Doppalapudi H, Yamada T, McElderry HT, Plumb VJ, Epstein AE, Kay GN. Ventricular tachycardia originating from the posterior papillary muscle in the left ventricle: a distinct clinical syndrome. Circ: Arrhythmia Electrophysiol. 2008;1:23–9.

    Google Scholar 

  69. Latchamsetty R, Bogun F. Premature ventricular complexes and premature ventricular complex induced cardiomyopathy. Curr Probl Cardiol. 2015;40:379–422.

    Article  PubMed  Google Scholar 

  70. Yokokawa M, Good E, Crawford T, et al. Recovery from left ventricular dysfunction after ablation of frequent premature ventricular complexes. Heart Rhythm. 2013;10:172–5.

    Article  PubMed  Google Scholar 

  71. Holmqvist F, Kesek M, Englund A, et al. A decade of catheter ablation of cardiac arrhythmias in Sweden: ablation practices and outcomes. Eur Heart J. 2019;40:820–30.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David Duncker .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Duncker, D., Müller-Leisse, J.L., Zormpas, C., Eiringhaus, J., Veltmann, C. (2020). Ventricular Ectopic Ablation. In: Sohaib, A. (eds) Decoding Cardiac Electrophysiology. Springer, Cham. https://doi.org/10.1007/978-3-030-28672-9_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-28672-9_7

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-28671-2

  • Online ISBN: 978-3-030-28672-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics