Skip to main content
SpringerLink
Log in
Book cover

Endometrial Gene Expression pp 117–124Cite as

Endometrial Gene Expression for HHV-6

  • Chapter
  • First Online:

  • 372 Accesses

Abstract

Viral infections have been considered as possible environmental factors in human infertility. Two studies have confirmed the association of HHV-6 expression of endometrial cells and infertility providing a compelling suggestion of a role of HHV-6 in the etiology of infertility. This chapter describes HHV-6, discusses the association of HHV-6 and infertility, and reviews methods of detection of HHV-6 expression within the uterus.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Milne SA, Critchley HO, Drudy TA, Kelly RW, Baird DT. Perivascular interleukin-8 messenger ribonucleic acid expression in human endometrium varies across the menstrual cycle and in early pregnancy decidua. J Clin Endocrinol Metab. 1999;84:2563–7.

    CAS  PubMed  Google Scholar 

  2. Seli MD, Senturk LM, Bahtiyar OM, Kayisli UA, Arici A. Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. Fertil Steril. 2001;75:1172–6.

    Article  CAS  Google Scholar 

  3. Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alamá P, Pellicer A, et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril. 2011;95:50–60.

    Article  Google Scholar 

  4. Talbi S, Hamilton AE, Vo KC, Tulac S, Overgaard MT, Dosiou C, et al. Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women. Endocrinology. 2006;147:1097–121.

    Article  CAS  Google Scholar 

  5. Timeva T, Shterev A, Kyurkchiev S. Recurrent implantation failure: the role of the endometrium. J Repro Infertil. 2014;15:173–83.

    Google Scholar 

  6. Romero R, Espinoza J, Mazor M. Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization? Fertil Steril. 2004;82:799–804.

    Article  Google Scholar 

  7. Rhoads DD, Cox SB, Rees EJ, Sun Y, Wolcott RD. clinical identification of bacteria in human chronic wound infections: culturing vs. 16S ribosomal DNA sequencing. BMC Infect Dis. 2012;12:321–6.

    Article  Google Scholar 

  8. Cicinelli E, Matteo M, Tinelli R, Lepera A, Alfonso R, Indraccolo U, et al. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Hum Reprod. 2015;30:323–30.

    Article  Google Scholar 

  9. Marci R, Gentili V, Bortolotti D, Lo Monte G, Caselli E, Bolzan S, et al. Presence of HHV-6A in endometrial epithelial cells from women with primary unexplained infertility. PLoS One. 2016;11:e0158304.

    Article  Google Scholar 

  10. Coulam CB, Bilal M, Salazar Garcia MD, Katukurundage D, Elazzamy H, Fernandez EF, et al. Prevalence of HHV-6 in endometrium from women with recurrent implantation failure. Am J Reprod Immunol. 2018;80:e12862.

    Article  Google Scholar 

  11. Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet. 1988;1:1065–7.

    Article  CAS  Google Scholar 

  12. De Bolle L, Naesens L, De Clercq E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev. 2005;18:217–45.

    Article  Google Scholar 

  13. Santoro F, Kennedy PE, Locatelli G, Malnati MS, Berger EA, Lusso P. CD46 is a cellular receptor for human herpesvirus 6. Cell. 1999;99:817–27.

    Article  CAS  Google Scholar 

  14. Cook SD, Paveloff MJ, Doucet JJ, Cottingham AJ, Sedarati F, Hill JM. Ocular herpes simplex virus reactivation in mice latently infected with latency-associated transcript mutants. Investig Ophthalmol. 1991;32:1558–61.

    CAS  Google Scholar 

  15. Baecher-Lind LE, Miller W, Wilcox AJ. Infectious disease and reproductive health: a review. Obstet Gynecol Surv. 2010;65:53–65.

    Article  Google Scholar 

  16. Naumenko V, Tyulenev Y, Kurilo L, Shileiko L, Sorokina T, Evdokimov V, et al. Detection and quantification of human herpes viruses types 4–6 in sperm samples of patients with fertility disorders and chronic inflammatory urogenital tract diseases. Androl. 2014;2:687–94.

    Article  CAS  Google Scholar 

  17. Wang H, Chen M, Berneman ZN, Delgado G, DiPaolo JA. Detection of human herpesvirus-6 in paraffin-embedded tissue of cervical cancer by polymerase chain reaction. J Virol Methods. 1994;47:297–305.

    Article  CAS  Google Scholar 

  18. Ohashi M, Yoshikawa T, Ihira M, Suzuki K, Suga S, Tada S, et al. Reactivation of human herpesvirus 6 and 7 in pregnant women. J Med Virol. 2002;67:354–8.

    Article  Google Scholar 

  19. Okuno T, Oishi H, Hayashi K, Nonogaki M, Tanaka K, Yamanishi K. Human herpesviruses 6 and 7 in cervixes of pregnant women. J Clin Microbiol. 1995;33:1968–70.

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Baillargeon J, Piper J, Leach CT. Epidemiology of human herpesvirus 6 (HHV-6) infection in pregnant and nonpregnant women. J Clin Virol. 2002;16:149–57.

    Article  Google Scholar 

  21. Maeda T, Okuno T, Hayashi K, Nagata M, Ueda M, Terashima K, et al. Outcomes of infants whose mothers are positive for human herpesvirus-6 DNA within the genital tract in early gestation. Acta Paediatr Jpn. 1997;39:653–7.

    Article  CAS  Google Scholar 

  22. Leach CT, Newton ER, McParlin S, Jenson HB. Human herpesvirus 6 infection of the female genital tract. J Infect Dis. 1994;169:1281–3.

    Article  CAS  Google Scholar 

  23. Aubin JT, Collandre H, Candotti D, Ingrand D, Rouzioux C, Burgard M, et al. Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction. J Clin Microbiol. 1991;29:367–72.

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Tang H, Serada S, Kawabata A, Ota M, Hayashi E, Naka T, et al. CD134 is a cellular receptor specific for human herpesvirus-6B entry. Proc Natl Acad Sci U S A. 2013;110:9096–9.

    Article  CAS  Google Scholar 

  25. Rizzo R, DiLuca D. Endometrium infection by human herpes virus 6A: implication in female idiopathic infertility. Fertil Steril. 2018;110:e128.

    Article  Google Scholar 

  26. Miguel RDV, Sheridan BS, Harvey SAK, Schreiner RS, Hendricks RL, Cherpes TL. 17-β estradiol promotion of herpes simplex virus type 1 reactivation is estrogen receptor dependent. J Virol. 2010;84:565–72.

    Article  CAS  Google Scholar 

  27. Caselli E, Zatelli M, Rizzo R, Benedetti S, Martorelli D, Trasforini G, et al. Virologic and immunologic evidence supporting an association between HHV-6 and Hashimoto’s thyroiditis. PLoS Pathog. 2012;8:e1002951.

    Article  CAS  Google Scholar 

  28. Davies ML, Dambaeva SV, Katukurundage D, Repak M, Gilman-Sachs A, Kwak-Kim J, Beaman KD. Predicting NK cell subsets using gene expression levels in peripheral blood and endometrial biopsy specimens. Am J Reprod Immunol. 2017;78:e12730.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA

    Carolyn Coulam

Authors
  1. Carolyn Coulam
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Reproductive Medicine and Immunology Clinical Sciences, Obstetrics and Gynecology, Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA

    Joanne Kwak-Kim

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Coulam, C. (2020). Endometrial Gene Expression for HHV-6. In: Kwak-Kim, J. (eds) Endometrial Gene Expression. Springer, Cham. https://doi.org/10.1007/978-3-030-28584-5_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-28584-5_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-28583-8

  • Online ISBN: 978-3-030-28584-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation