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A Potential Role of Phospholipase 2 Group IIA (PLA2-IIA) in P. gingivalis-Induced Oral Dysbiosis

  • Conference paper
Oral Mucosal Immunity and Microbiome

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1197))

Abstract

Porphyromonas gingivalis is an oral pathogen with the ability to induce oral dysbiosis and periodontal disease. Nevertheless, the mechanisms by which P. gingivalis could abrogate the host–microbe symbiotic relationship leading to oral dysbiosis remain unclear. We have recently demonstrated that P. gingivalis specifically increased the antimicrobial properties of oral epithelial cells, through a strong induction of the expression of PLA2-IIA in a mechanism that involves activation of the Notch-1 receptor. Moreover, gingival expression of PLA2-IIA was significantly increased during initiation and progression of periodontal disease in non-human primates and interestingly, those PLA2-IIA expression changes were concurrent with oral dysbiosis. In this chapter, we present an innovative hypothesis of a potential mechanism involved in P. gingivalis-induced oral dysbiosis and inflammation based on our previous observations and a robust body of literature that supports the antimicrobial and proinflammatory properties of PLA2-IIA as well as its role in other chronic inflammatory diseases.

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Acknowledgements

Findings reported in this review were funded by NIH/NIDCR grant DE024804, NIH/NIGMS P20GM103538 and College of Dentistry University of Kentucky. We thank Drs. Yongzheng Wu and Lhousseine Touqi from Institute Pasteur for kindly sharing the hPLA2-IIA-Tg mice as well as Drs. Jorge Frias (U. of Florida) and Sreenatha Kirakodu (U. of Kentucky) for their support in oral microbiome preliminary analysis. We also are grateful to Dr. Brittany Camenisch and Division of Periodontology for supporting the ongoing preliminary clinical study in salivary PLA2-IIA levels.

Conflict of Interest: The authors have no conflicts of interest.

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Authors and Affiliations

  1. Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA

    Octavio A. Gonzalez, Vanessa Euzebio-Alves, Yelena Alimova & Ahmad Al-Attar

  2. Division of Periodontics, College of Dentistry, University of Kentucky, Lexington, KY, USA

    Octavio A. Gonzalez

  3. Department of Biomedical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, Las Vegas, NV, USA

    J. L. Ebersole

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  1. Octavio A. Gonzalez
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  2. Vanessa Euzebio-Alves
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  3. Yelena Alimova
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Correspondence to Octavio A. Gonzalez .

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  1. Division of Oral Diseases, Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden

    Georgios N. Belibasakis  & Nagihan Bostanci  & 

  2. Department of Microbiology, University of Pennsylvania, Penn Dental Medicine, Philadelphia, PA, USA

    George Hajishengallis

  3. King’s College London Dental Institute, London, UK

    Michael A. Curtis

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Gonzalez, O.A., Euzebio-Alves, V., Alimova, Y., Al-Attar, A., Ebersole, J.L. (2019). A Potential Role of Phospholipase 2 Group IIA (PLA2-IIA) in P. gingivalis-Induced Oral Dysbiosis. In: Belibasakis, G.N., Hajishengallis, G., Bostanci, N., Curtis, M.A. (eds) Oral Mucosal Immunity and Microbiome. Advances in Experimental Medicine and Biology, vol 1197. Springer, Cham. https://doi.org/10.1007/978-3-030-28524-1_7

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