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Candida–Bacterial Biofilms and Host–Microbe Interactions in Oral Diseases

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Oral Mucosal Immunity and Microbiome

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1197))

Abstract

Oral cavity harbors a complex and highly diverse microbial community. Cross-kingdom interactions between Candida and oral bacteria are critical for their co-existence, which may also affect the course and the severity of biofilm-mediated bacterial-mediated diseases. C. albicans has been found in polymicrobial biofilms associated with denture stomatitis, oral mucositis, dental caries, periodontal diseases, peri-implantitis, and root canal infection. Thus, it is of utmost importance to unravel the mechanisms of Candida–bacterial interactions and their impact on the onset and severity of cross-kingdom biofilm-related diseases. Here, we highlight the potential role of Candida–bacterial biofilm interactions in the pathogenesis of oral diseases, especially mucosal infections and dental caries. The influence of Candida–bacterial biofilms on the mucosal host immune response is also discussed. Finally, we present some of the current and prospective therapeutic strategies for controlling these cross-kingdom interactions and their virulence properties associated with oral diseases.

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Acknowledgement

The authors would like to thank Fundação de Amparo à Pesquisa do Estado de São Paulo [FAPESP-BEPE 2018/18258-8 (T. C. Negrini)] and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior [CAPES-PEVEX 88881.171614/2018-01 (R. A. Arthur)].

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Authors and Affiliations

  1. Biofilm Research Laboratory, Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Thais de Cássia Negrini, Hyun Koo & Rodrigo Alex Arthur

  2. Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, SP, Brazil

    Thais de Cássia Negrini

  3. Preventive and Community Dentistry Department, Dental School, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

    Rodrigo Alex Arthur

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  1. Thais de Cássia Negrini
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  2. Hyun Koo
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  3. Rodrigo Alex Arthur
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Correspondence to Hyun Koo or Rodrigo Alex Arthur .

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  1. Division of Oral Diseases, Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden

    Georgios N. Belibasakis  & Nagihan Bostanci  & 

  2. Department of Microbiology, University of Pennsylvania, Penn Dental Medicine, Philadelphia, PA, USA

    George Hajishengallis

  3. King’s College London Dental Institute, London, UK

    Michael A. Curtis

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Negrini, T.d.C., Koo, H., Arthur, R.A. (2019). Candida–Bacterial Biofilms and Host–Microbe Interactions in Oral Diseases. In: Belibasakis, G.N., Hajishengallis, G., Bostanci, N., Curtis, M.A. (eds) Oral Mucosal Immunity and Microbiome. Advances in Experimental Medicine and Biology, vol 1197. Springer, Cham. https://doi.org/10.1007/978-3-030-28524-1_10

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