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Immunological Considerations for Retinal Stem Cell Therapy

  • Joshua Kramer
  • Kathleen R. Chirco
  • Deepak A. LambaEmail author
Chapter
First Online:
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1186)

Abstract

There is an increasing effort toward generating replacement cells for neuronal application due to the nonregenerative nature of these tissues. While much progress has been made toward developing methodologies to generate these cells, there have been limited improvements in functional restoration. Some of these are linked to the degenerative and often nonreceptive microenvironment that the new cells need to integrate into. In this chapter, we will focus on the status and role of the immune microenvironment of the retina during homeostasis and disease states. We will review changes in both innate and adaptive immunity as well as the role of immune rejection in stem cell replacement therapies. The chapter will end with a discussion of immune-modulatory strategies that have helped to ameliorate these effects and could potentially improve functional outcome for cell replacement therapies for the eye.

Keywords

Immune modulation Cell replacement Microglia Macrophages Muller glia Complement system Immune rejection Inflammasome 
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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Joshua Kramer
    • 2
  • Kathleen R. Chirco
    • 2
  • Deepak A. Lamba
    • 2
    • 1
    Email author
  1. 1.Department of OphthalmologyUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Buck Institute for Research on AgingNovatoUSA

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