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Immunological Considerations for Retinal Stem Cell Therapy

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Pluripotent Stem Cells in Eye Disease Therapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1186))

Abstract

There is an increasing effort toward generating replacement cells for neuronal application due to the nonregenerative nature of these tissues. While much progress has been made toward developing methodologies to generate these cells, there have been limited improvements in functional restoration. Some of these are linked to the degenerative and often nonreceptive microenvironment that the new cells need to integrate into. In this chapter, we will focus on the status and role of the immune microenvironment of the retina during homeostasis and disease states. We will review changes in both innate and adaptive immunity as well as the role of immune rejection in stem cell replacement therapies. The chapter will end with a discussion of immune-modulatory strategies that have helped to ameliorate these effects and could potentially improve functional outcome for cell replacement therapies for the eye.

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Authors and Affiliations

  1. Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA

    Deepak A. Lamba

  2. Buck Institute for Research on Aging, Novato, CA, USA

    Joshua Kramer, Kathleen R. Chirco & Deepak A. Lamba

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  1. Joshua Kramer
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  2. Kathleen R. Chirco
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  3. Deepak A. Lamba
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Correspondence to Deepak A. Lamba .

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  1. National Institutes of Health NEI, Bethesda, MD, USA

    Kapil Bharti

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Kramer, J., Chirco, K.R., Lamba, D.A. (2019). Immunological Considerations for Retinal Stem Cell Therapy. In: Bharti, K. (eds) Pluripotent Stem Cells in Eye Disease Therapy. Advances in Experimental Medicine and Biology, vol 1186. Springer, Cham. https://doi.org/10.1007/978-3-030-28471-8_4

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