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Major Subtypes of Renal Cell Carcinoma

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Kidney Cancer

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Abstract

Renal cell carcinoma (RCC) and its treatment have consistently remained in the foreground as one of the most rapidly evolving areas in the ever-expanding field of solid tumor oncology. Significant developments have occurred over the past two decades in the clinical landscape that have vastly enhanced comprehension of etiopathogenesis of RCC and its modalities of management including advancements in minimally invasive surgical techniques, employment of focal therapy, increased renal biopsy-based approach, advancements in immunotherapy, adoption of active surveillance strategies, and the use of targeted treatment strategies for patients with advanced disease. Efforts aimed at morphologically grouping specific cancers into distinct pathologic subtypes have not only allowed a common descriptive language, but are helping to crystallize the understanding of RCC’s molecular origins and its clinical behavior. It is these improved insights into the similarities and differences among RCC variants that offer clinical and therapeutic opportunities to improve patient care.

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Authors and Affiliations

  1. Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA

    Mukul K. Divatia & Jae Y. Ro

  2. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Charles C. Guo

  3. Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill-Cornell Medical College, Houston, TX, USA

    Aseeb Rehman

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  1. Mukul K. Divatia
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  4. Jae Y. Ro
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Correspondence to Mukul K. Divatia .

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  1. Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA

    Mukul K. Divatia

  2. Gulhane Military Medical Academy, School of Medicine, Department of Pathology, Ankara, Turkey

    Ayhan Ozcan

  3. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Charles C. Guo

  4. Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA

    Jae Y. Ro

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Divatia, M.K., Guo, C.C., Rehman, A., Ro, J.Y. (2020). Major Subtypes of Renal Cell Carcinoma. In: Divatia, M., Ozcan, A., Guo, C., Ro, J. (eds) Kidney Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-28333-9_5

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