Skip to main content
SpringerLink
Log in
Book cover

Kidney Cancer pp 47–75Cite as

Benign Renal Epithelial / Epithelial and Stromal Tumors

  • Chapter
  • First Online:

  • 996 Accesses

Abstract

Benign renal neoplasms are heterogeneous group of tumors with a broad spectrum of distinctive ontogeny, histology, and biology. They are classified into renal cell tumors, metanephric tumors, mesenchymal tumors, and mixed epithelial and stromal tumors. Although some exhibit characteristic anatomic distribution and imaging features, histologic evaluation is usually required to reach final diagnosis due to overlapping findings between benign and malignant renal proliferations.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Moch H, Humprey PA, Ulbrignt TM, Reuter VE. WHO classification of tumours of the urinary system and male genital organs. Lyon: IARC Press; 2016.

    Google Scholar 

  2. Grignon DJ, Eble JN. Papillary and metanephric adenomas of the kidney. Semin Diagn Pathol. 1998;15:41–53.

    CAS  PubMed  Google Scholar 

  3. Wang KL, Weinrach DM, Luan C, et al. Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma. Hum Pathol. 2007;38:239–46.

    Article  CAS  PubMed  Google Scholar 

  4. Denton MD, Magee CC, Ovuworie C, et al. Prevalence of renal cell carcinoma in patients with ESRD pre-transplantation: a pathologic analysis. Kidney Int. 2002;61:2201–9.

    Article  PubMed  Google Scholar 

  5. Hughson MD, Buchwald D, Fox M. Renal neoplasia and acquired cystic kidney disease in patients receiving long-term dialysis. Arch Pathol Lab Med. 1986;110:592–601.

    CAS  PubMed  Google Scholar 

  6. Cohen C, McCue PA, DeRose PB. Immunohistochemistry of renal adenomas and carcinomas. J Urol Pathol. 1995;3:61–71.

    Google Scholar 

  7. Kovacs G, Fuzesi L, Emanual E, et al. Cytogenetics of papillary renal cell tumors. Genes Chromosomes Cancer. 1991;3:249–55.

    Article  CAS  PubMed  Google Scholar 

  8. Trpkov K, Yilmaz A, Uzer D, et al. Renal oncocytoma revisited: a clinicopathologic study of 109 cases with emphasis on problematic diagnostic features. Histopathology. 2010;57:893–906.

    Article  PubMed  Google Scholar 

  9. Perez-Ordonez B, Hamed G, et al. Renal oncocytoma: a clinicopathologic study of 70 cases. Am J Surg Pathol. 1997;21:871–83.

    Article  CAS  PubMed  Google Scholar 

  10. Wobker SE, Przybycin CG, Sircar K, Epstein JI. Renal oncocytoma with vascular invasion: a series of 22 cases. Hum Pathol. 2016;58:1–6.

    Article  PubMed  Google Scholar 

  11. Petersson F, Síma R, Grossmann P, et al. Renal small cell oncocytoma with pseudorosettes A histomorphologic, immunohistochemical, and molecular genetic study of 10 cases. Hum Pathol. 2011;42:1751–60.

    Article  CAS  PubMed  Google Scholar 

  12. Joshi S, Tolkunov D, Aviv H, et al. The genomic landscape of renal oncocytoma identifies a metabolic barrier to tumorigenesis. Cell Rep. 2015;13:1895–908.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Goyal R, Parwani AV, Gellert L, et al. A collision tumor of papillary renal cell carcinoma and oncocytoma: case report and literature review. Am J Clin Pathol. 2015;144:811–6.

    Article  CAS  PubMed  Google Scholar 

  14. Liu S, Lee S, Rashid P, et al. Active surveillance is suitable for intermediate term follow-up of renal oncocytoma diagnosed by percutaneous core biopsy. BJU Int. 2016;118(Suppl 3):30–4.

    Article  PubMed  Google Scholar 

  15. Tickoo SK, Reuter VE, Amin MB, et al. Renal oncocytosis: a morphologic study of fourteen cases. Am J Surg Pathol. 1999;23:1094–101.

    Article  CAS  PubMed  Google Scholar 

  16. Adamy A, Lowrance WT, Yee DS, et al. Renal oncocytosis: management and clinical outcomes. J Urol. 2011;185:795–801.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Pavlovich CP, Grubb RL 3rd, Hurley K, et al. Evaluation and management of renal tumors in the Birt-Hogg-Dube syndrome. J Urol. 2005;173:1482–6.

    Article  PubMed  Google Scholar 

  18. Pavlovich CP, Walther MM, Eyler RA, et al. Renal tumors in the Birt-Hogg- Dube syndrome. Am J Surg Pathol. 2002;26:1542–52.

    Article  PubMed  Google Scholar 

  19. Gobbo S, Eble JN, Delahunt B, et al. Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles. Am J Surg Pathol. 2010;34:620–6.

    Article  PubMed  Google Scholar 

  20. Davis CJ Jr, Barton JH, Sesterhenn IA, Mostofi FK. Metanephric adenoma: clinicopathological study of fifty patients. Am J Surg Pathol. 1995;19:1101–14.

    Article  PubMed  Google Scholar 

  21. Drut R, Drut RM, Ortolani C. Metastatic metanephric adenoma with foci of papillary carcinoma in a child: a combined histologic, immunohistochemical, and FISH study. Int J Surg Pathol. 2001;9:241–7.

    Article  CAS  PubMed  Google Scholar 

  22. Li G, Tang Y, Zhang R, et al. Adult metanephric adenoma presumed to be all benign? A clinical perspective. BMC Cancer. 2015;15:310.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Muir TE, Cheville JC, Lager DJ. Metanephric adenoma, nephrogenic rests, and Wilms’ tumor: a histologic and immunophenotypic comparison. Am J Surg Pathol. 2001;25:1290–6.

    Article  CAS  PubMed  Google Scholar 

  24. Sun Z, Kan S, Zhang L, et al. Immunohistochemical phenotype and molecular pathological characteristics of metanephric adenoma. Int J Clin Exp Pathol. 2015;8:6031–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Kato H, Suzuki M, Aizawa S, Hano H. Metanephric adenoma of the kidney with massive hemorrhage and necrosis: immunohistochemical, ultrastructural, and flow cytometric studies. Int J Surg Pathol. 2003;11:345–52.

    Article  PubMed  Google Scholar 

  26. Kinney SN, Eble JN, Hes O, et al. Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma. Mod Pathol. 2015;28:1236–48.

    Article  CAS  PubMed  Google Scholar 

  27. Pesti T, Sukosd F, Jones EC, et al. Mapping a tumor suppressor gene to chromosome 2p13 in metanephric adenoma by microsatellite allelotyping. Hum Pathol. 2001;32:101–4.

    Article  CAS  PubMed  Google Scholar 

  28. Choueiri TK, Cheville J, Palescandolo E, et al. BRAF mutations in metanephric adenoma of the kidney. Eur Urol. 2012;62:917–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Udager AM, Pan J, Magers MJ, et al. Molecular and immunohistochemical characterization reveals novel BRAF mutations in metanephric adenoma. Am J Surg Pathol. 2015;39:549–57.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Paner GP, Turk TM, Clark JI, et al. Passive seeding in metanephric adenoma: a review of pseudometastatic lesions in perinephric lymph nodes. Arch Pathol Lab Med. 2005;129:1317–21.

    PubMed  Google Scholar 

  31. Renshaw AA, Freyer DR, Hammers YA. Metastatic metanephric adenoma in a child. Am J Surg Pathol. 2000;24:570–4.

    Article  CAS  PubMed  Google Scholar 

  32. Hennigar RA, Beckwith JB. Nephrogenic adenofibroma: a novel kidney tumor of young people. Am J Surg Pathol. 1992;16:325–34.

    Article  CAS  PubMed  Google Scholar 

  33. Arroyo MR, Green DM, Perlman EJ, et al. The spectrum of metanephric adenofibroma and related lesions: clinicopathologic study of 25 cases from the National Wilms Tumor Study Group Pathology Center. Am J Surg Pathol. 2001;25:433–44.

    Article  CAS  PubMed  Google Scholar 

  34. Piotrowski Z, Canter DJ, Kutikov A, et al. Metanephric adenofibroma: robotic partial nephrectomy of a large Wilms’ tumor variant. Can J Urol. 2010;17:5309–12.

    PubMed  Google Scholar 

  35. Galluzzo ML, Garcia de Davila MT, Vujanić GM. A composite renal tumor: metanephric adenofibroma, Wilms tumor, and renal cell carcinoma: a missing link? Pediatr Dev Pathol. 2012;15:65–70.

    Article  PubMed  Google Scholar 

  36. Argani P. Metanephric neoplasms: the hyperdifferentiated, benign end of the Wilms tumor spectrum. Clin Lab Med. 2005;25:379–92.

    Article  PubMed  Google Scholar 

  37. Mangray S, Breese V, Jackson CL, et al. Application of BRAF V600E mutation analysis for the diagnosis of metanephric adenofibroma. Am J Surg Pathol. 2015;39:1301–4.

    Article  PubMed  Google Scholar 

  38. Chami R, Yin M, Marrano P, et al. BRAF mutations in pediatric metanephric tumors. Hum Pathol. 2015;46:1153–61.

    Article  CAS  PubMed  Google Scholar 

  39. Yao DW, Qu F, Hu SW, et al. Metanephric adenofibroma in a 10-year-old boy: report of a case and review of the literature. Int J Clin Exp Pathol. 2015;8:3250–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Picken MM, Curry JL, Lindgren V, et al. Metanephric adenosarcoma in a young adult: morphologic, immunophenotypic, ultrastructural and fluorescence in situ hybridization analyses. Am J Surg Pathol. 2001;25:1451–7.

    Article  CAS  PubMed  Google Scholar 

  41. Tiefen S, Yan F, Zhu P. Metanephric adenosarcoma: a rare case with immunohistochemistry and molecular analysis. Diagn Pathol. 2014;9:179.

    Article  Google Scholar 

  42. Argani P, Beckwith JB. Metanephric stromal tumor: report of 31 cases of a distinctive pediatric pediatric renal neoplasm. Am J Surg Pathol. 2000;24:917–26.

    Article  CAS  PubMed  Google Scholar 

  43. Bluebond-Langner R, Pinto PA, Argani P, et al. Adult presentation of metanephric stromal tumour. J Urol. 2002;168:1482–3.

    Article  CAS  PubMed  Google Scholar 

  44. McDonald OG, Rodriguez R, Bergner A, et al. Metanephric stromal tumour arising in a patient with neurofibromatosis type 1 syndrome. Int J Surg Pathol. 2011;19:667–71.

    Article  PubMed  Google Scholar 

  45. Argani P, Lee J, Netto GJ, et al. Frequent BRAF V600E mutations in metanephric stromal tumor. Am J Surg Pathol. 2016;40:719–22.

    Article  PubMed  Google Scholar 

  46. De Pasquale MD, Diomedi-Camassei F, Serra A, et al. Recurrent metanephric stromal tumor in an infant. Urology. 2011;78:1411–3.

    Article  PubMed  Google Scholar 

  47. Adsay NV, Eble JN, Srigley JR, et al. Mixed epithelial and stromal tumor of the kidney. Am J Surg Pathol. 2000;24:958–70.

    Article  CAS  PubMed  Google Scholar 

  48. Turbiner J, Amin MB, Humphrey PA, et al. Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. Am J Surg Pathol. 2007;31:489–500.

    Article  PubMed  Google Scholar 

  49. Michal M, Hes O, Bisceglia M, et al. Mixed epithelial and stromal tumors of the kidney. A report of 22 cases. Virchows Arch. 2004;445:359–67.

    Article  PubMed  Google Scholar 

  50. Montironi R, Mazzucchelli R, Lopez-Beltran A, et al. Cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity? Eur Urol. 2008;54:1237–46.

    Article  PubMed  Google Scholar 

  51. Kalra S, Manikandan R, Dorairajan LN. Giant renal mixed epithelial and stromal tumour in a young female: a rare presentation. J Clin Diagn Res. 2015;9:XD01–2.

    PubMed  PubMed Central  Google Scholar 

  52. Yang Y, Ondrej H, Zhang L, et al. Mixed epithelial and stromal tumor of the kidney with cervical and intestinal differentiation. Virchows Arch. 2005;447:669–71.

    Article  PubMed  Google Scholar 

  53. Caliò A, Eble JN, Grignon DJ, Delahunt B. Mixed epithelial and stromal tumor of the kidney: a clinicopathologic study of 53 cases. Am J Surg Pathol. 2016;40:1538–49.

    Article  PubMed  Google Scholar 

  54. Svec A, Hes O, Michal M, Zachoval R. Malignant mixed epithelial and stromal tumor of the kidney. Virchows Arch. 2001;439:700–2.

    Article  CAS  PubMed  Google Scholar 

  55. Nakagawa T, Kanai Y, Fujimoto H, et al. Malignant mixed epithelial and stromal tumours of the kidney: a report of the first two cases with a fatal clinical outcome. Histopathology. 2004;44:302–4.

    Article  CAS  PubMed  Google Scholar 

  56. Jung SJ, Shen SS, Tran T, et al. Mixed epithelial and stromal tumor of kidney with malignant transformation: report of two cases and review of literature. Hum Pathol. 2008;39:463–8.

    Article  CAS  PubMed  Google Scholar 

  57. Zou L, Zhang X, Xiang H. Malignant mixed epithelial and stromal tumor of the kidney: the second male case and review of literature. Int J Clin Exp Pathol. 2014;7:2658–63.

    PubMed  PubMed Central  Google Scholar 

  58. Suzuki T, Hiragata S, Hosaka K, et al. Malignant mixed epithelial and stromal tumor of the kidney: report of the first male case. Int J Urol. 2013;20:448–50.

    Article  PubMed  Google Scholar 

  59. Menéndez CL, Rodríguez VD, Fernández-Pello S, et al. A new case of malignant mixed epithelial and stromal tumor of the kidney with rhabdomyosarcomatous transformation. Anal Quant Cytopathol Histpathol. 2012;34:331–4.

    PubMed  Google Scholar 

  60. Sukov WR, Cheville JC, Lager DJ, et al. Malignant mixed epithelial and stromal tumor of the kidney with rhabdoid features: report of a case including immunohistochemical, molecular genetic studies and comparison to morphologically similar renal tumors. Hum Pathol. 2007;38:1432–7.

    Article  CAS  PubMed  Google Scholar 

  61. Mudaliar KM, Mehta V, Gupta GN, Picken MM. Expanding the morphologic spectrum of adult biphasic renal tumors – mixed epithelial and stromal tumor of the kidney with focal papillary renal cell carcinoma: case report and review of the literature. Int J Surg Pathol. 2014;22:266–71.

    Article  PubMed  Google Scholar 

  62. Farias JA, Laryea J, Gokden N, Kamel MH. Peritoneal seeding following incomplete resection of mixed epithelial stromal tumor of the kidney: first case report. Urol Ann. 2016;8:114–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Koç University School of Medicine, İstanbul, Turkey

    Dilek Ertoy Baydar

Authors
  1. Dilek Ertoy Baydar
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA

    Mukul K. Divatia

  2. Gulhane Military Medical Academy, School of Medicine, Department of Pathology, Ankara, Turkey

    Ayhan Ozcan

  3. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Charles C. Guo

  4. Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA

    Jae Y. Ro

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ertoy Baydar, D. (2020). Benign Renal Epithelial / Epithelial and Stromal Tumors. In: Divatia, M., Ozcan, A., Guo, C., Ro, J. (eds) Kidney Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-28333-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-28333-9_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-28332-2

  • Online ISBN: 978-3-030-28333-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation