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Antibody Complexes

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Book cover Macromolecular Protein Complexes II: Structure and Function

Part of the book series: Subcellular Biochemistry ((SCBI,volume 93))

Abstract

Monoclonal based therapeutics have always been looked at as a futuristic natural way we could take care of pathogens and many diseases. However, in order to develop, establish and realize monoclonal based therapy we need to understand how the immune system contains or kill pathogens. Antibody complexes serve the means to decode this black box. We have discussed examples of antibody complexes both at biochemical and structural levels to understand and appreciate how discoveries in the field of antibody complexes have started to decoded mechanism of viral invasion and create potential vaccine targets against many pathogens. Antibody complexes have made advancement in our knowledge about the molecular interaction between antibody and antigen. It has also led to identification of potent protective monoclonal antibodies. Further use of selective combination of monoclonal antibodies have provided improved protection against deadly diseases. The administration of newly designed and improved immunogen has been used as potential vaccine. Therefore, antibody complexes are important tools to develop new vaccine targets and design an improved combination of monoclonal antibodies for passive immunization or protection with very little or no side effects.

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Authors and Affiliations

  1. Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan

    Reetesh Raj Akhouri, Lars-Göran Öfverstedt, Gunnar Wilken & Ulf Skoglund

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  1. Reetesh Raj Akhouri
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  2. Lars-Göran Öfverstedt
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  3. Gunnar Wilken
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  4. Ulf Skoglund
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Correspondence to Ulf Skoglund .

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Editors and Affiliations

  1. Institute of Zoology, University of Mainz, Mainz, Germany

    J. Robin Harris

  2. School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, UK

    Jon Marles-Wright

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Akhouri, R.R., Öfverstedt, LG., Wilken, G., Skoglund, U. (2019). Antibody Complexes. In: Harris, J., Marles-Wright, J. (eds) Macromolecular Protein Complexes II: Structure and Function . Subcellular Biochemistry, vol 93. Springer, Cham. https://doi.org/10.1007/978-3-030-28151-9_2

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