Abstract
Metabolism and cell cycle are two central processes in the life of a eukaryote cell. If they have been extensively studied in their own right, their interconnection remains relatively poorly understood. In this paper, we propose to use a differential model of the central carbon metabolism. After verifying the model accurately reproduces known metabolic variations during the cell cycle’s phases, we extend it into a hybrid system reproducing an imposed succession of the phases. This first hybrid approach qualitatively recovers observations made in the literature, providing an interesting first step towards a better understanding of the crosstalks between cell cycle and metabolism.
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Notes
- 1.
Note that this fact amounts to supposing that the “genetic part” of the cell ensures the maintenance of enzymatic pools.
- 2.
For the sake of simplicity, the demands in amino acids are ignored in this paper.
- 3.
in [3], the range of variation of redox ratios is low in normal cells with respect to cancer cells.
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Moulin, C., Tournier, L., Peres, S. (2019). Using a Hybrid Approach to Model Central Carbon Metabolism Across the Cell Cycle. In: Češka, M., Paoletti, N. (eds) Hybrid Systems Biology. HSB 2019. Lecture Notes in Computer Science(), vol 11705. Springer, Cham. https://doi.org/10.1007/978-3-030-28042-0_9
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DOI: https://doi.org/10.1007/978-3-030-28042-0_9
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