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Venom Allergy and Management in Mastocytosis

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Mastocytosis

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Abstract

Hymenoptera venom allergy (HVA) represents an important cause of morbidity and mortality worldwide. HVA is a typical IgE-mediated reaction due to sensitization to one or more allergens of the venom, and accounts for 1.5–34% of all cases of anaphylaxis.

Up to 7% of adult patients with HVA are affected by clonal mast cell disease (CMD). Moreover, up to 75% of patients with severe HVA have a risk of further severe reactions if re-stung: their prevention is based on prescription of adrenaline autoinjectors, correct allergologic workup followed, when indicated, by specific venom immunotherapy (VIT), and diagnosis of underlined CMD, if suspected. The diagnosis of a CMD leads to therapeutic consequences concerning the treatment of HVA: in particular, these patients have to undergo long-life VIT in order to prevent further, potentially fatal severe reactions.

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Authors and Affiliations

  1. Allergy Unit, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy

    Patrizia Bonadonna

  2. Multidisciplinary Outpatients Clinic for Mastocytosis (GISM), Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy

    Patrizia Bonadonna & Roberta Zanotti

  3. Department of Medicine, Hematology Unit, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy

    Roberta Zanotti

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  1. Patrizia Bonadonna
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Correspondence to Patrizia Bonadonna .

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Editors and Affiliations

  1. Professor of Medicine, Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, MI, USA

    Cem Akin

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Bonadonna, P., Zanotti, R. (2020). Venom Allergy and Management in Mastocytosis. In: Akin, C. (eds) Mastocytosis. Springer, Cham. https://doi.org/10.1007/978-3-030-27820-5_10

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