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18F-NaF

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Radiopharmaceuticals

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Abstract

18F-NaF PET/CT is a well-established and validated imaging tool for imaging skeletal system. The bio-distribution represents blood flow that varies among different bones; due to urinary excretion, bladder and kidneys can be normally visualized. The role of this tracer has been well demonstrated in imaging bone metastases, with sensitivity superior to 18F-FDG PET/CT and other conventional imaging modalities. In particular, 18F-NaF PET/CT can detect bone malignant involvement before lesions can be radiologically documented; however, a lack of specificity should be considered, due to the possibility of uptake in benign diseases as calcium deposits in brain and large arteries, osteoarthritis and post-traumatic lesions. Beyond oncology, this tracer can play a role in forensic use, evaluation of skeletal benign diseases, and atherosclerotic plaque.

18F-NaF uptake is also documented in meningioma, rheumatoid arthritis, amyloidosis, and lymphomas. Globally, nuclear medicine physicians must take into account the possibility of 18F-NaF uptake in all calcifications that can occur in benign or malignant diseases.

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Abbreviations

18F-FDG:

18F-fluorodeoxyglucose

99mTc-MDP:

99mTc-methyldiphosfonate

CT:

Computed tomography

EANM:

European Association of Nuclear Medicine and Molecular Imaging

FDA:

Food and Drug Administration

MIP:

Maximum intensity projection

PET/CT:

Positron emission computed tomography/computed tomography

SPECT:

Single photon emission computed tomography/computed tomography

SUV:

Standardized uptake value

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Author information

Authors and Affiliations

  1. Department of Nuclear Medicine and Theranostics, “Mariano Santo” Hospital, Cosenza, Italy

    Ferdinando Calabria

  2. Department of Biomedicine and Prevention, University “Tor Vergata”, Rome, Italy

    Orazio Schillaci

  3. Department of Nuclear Medicine and Molecular Imaging, IRCCS Neuromed, Pozzilli, IS, Italy

    Orazio Schillaci

Authors
  1. Ferdinando Calabria
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  2. Orazio Schillaci
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Corresponding author

Correspondence to Ferdinando Calabria .

Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine and Theranostics, Mariano Santo Hospital, Cosenza, Italy

    Ferdinando Calabria

  2. Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

    Orazio Schillaci

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Calabria, F., Schillaci, O. (2020). 18F-NaF. In: Calabria, F., Schillaci, O. (eds) Radiopharmaceuticals. Springer, Cham. https://doi.org/10.1007/978-3-030-27779-6_5

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  • DOI: https://doi.org/10.1007/978-3-030-27779-6_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-27778-9

  • Online ISBN: 978-3-030-27779-6

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