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HNE Microemulsion: Development, Rheological Characterization and In Vitro Release Studies

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Proceedings of the Iberian Meeting on Rheology (IBEREO 2019) (IBEREO 2019)

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Abstract

Human neutrophil elastase (HNE) is involved in the degradation of matrix proteins playing an important role in inflammation modulation. In this study, a microemulsion (ME) containing a new human neutrophil elastase inhibitor was developed and characterized in terms of pH, rheology (viscosity and oscillatory experiments) and drug release. This formulation is suitable for topical application to treat inflammatory diseases.

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References

  1. Marto, J., Ruivo, E., Lucas, S.D., Gonçalves, L.M., Simões, S., Gouveia, L.F., et al.: Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance. Eur. J. Pharm. 127, 1–11 (2018)

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  2. Santana, A.B., Lucas, S.D., Gonçalves, L.M., Correia, H.F., Cardote, T.A.F., Guedes, R.C., et al.: N-Acyl and N-sulfonyloxazolidine-2, 4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg. Med. Chem. Lett. 22, 3993–3997 (2012)

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Author information

Authors and Affiliations

  1. Faculty of Pharmacy, Universidade de Lisboa, ‎Lisbon, Portugal

    Andreia Nunes

  2. Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, ‎Lisbon, Portugal

    Joana Marto, Francisca Lopes & Helena Margarida Ribeiro

Authors
  1. Andreia Nunes
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  2. Joana Marto
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  3. Francisca Lopes
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  4. Helena Margarida Ribeiro
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Corresponding author

Correspondence to Andreia Nunes .

Editor information

Editors and Affiliations

  1. Department of Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal

    Francisco José Galindo-Rosales

  2. Department of Mechanical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal

    Laura Campo-Deaño

  3. Department of Mechanical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal

    Alexandre M. Afonso

  4. Department of Chemical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal

    Manuel A. Alves

  5. Department of Mechanical Engineering, Faculty of Engineering, University of Porto, Porto, Portugal

    Fernando T. Pinho

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Nunes, A., Marto, J., Lopes, F., Ribeiro, H.M. (2020). HNE Microemulsion: Development, Rheological Characterization and In Vitro Release Studies. In: Galindo-Rosales, F., Campo-Deaño, L., Afonso, A., Alves, M., Pinho, F. (eds) Proceedings of the Iberian Meeting on Rheology (IBEREO 2019). IBEREO 2019. Springer Proceedings in Materials. Springer, Cham. https://doi.org/10.1007/978-3-030-27701-7_19

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  • DOI: https://doi.org/10.1007/978-3-030-27701-7_19

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-27700-0

  • Online ISBN: 978-3-030-27701-7

  • eBook Packages: EngineeringEngineering (R0)

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