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Physiological Mechanisms of Bariatric Procedures

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The ASMBS Textbook of Bariatric Surgery

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Abstract

Bariatric surgery is the most effective intervention for sustained long-term weight loss, and it has been extensively demonstrated to improve and resolve most of the comorbidities associated with severe obesity. Traditionally, the accepted physiological mechanisms of bariatric procedures were based on the concepts of restriction of calorie intake, malabsorption of nutrients, and a combination of the two. As the close interactions between dietary balance and gastrointestinal and neuroendocrine pathways unravel, the physiological mechanisms of these procedures, as well as their classification, have significantly changed. In fact, it has currently become well recognized how the centrally regulated body weight homeostasis and target organ metabolic function are profoundly influenced by hormones secreted in the intestinal tract and adipose tissue. The overall balance of these peripherally secreted hormones, their systemic effects, and their interaction at the level of the hypothalamus would eventually affect food intake and energy expenditure.

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Authors and Affiliations

  1. Department of General Surgery, The Bariatric and Metabolic Institute, Cleveland Clinic Florida, Weston, FL, USA

    David Romero Funes, Emanuele Lo Menzo, Samuel Szomstein & Raul J. Rosenthal

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  1. David Romero Funes
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  2. Emanuele Lo Menzo
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  3. Samuel Szomstein
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  4. Raul J. Rosenthal
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Correspondence to David Romero Funes .

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Editors and Affiliations

  1. Department of Surgery, Division of Gastrointestinal Surgery, University of California, Irvine Medical Center, Orange, CA, USA

    Ninh T. Nguyen

  2. Department of Surgery, The Ohio State University, Columbus, OH, USA

    Stacy A. Brethauer

  3. Bariatric and Minimally Invasive Surgery Division, Yale School of Medicine, New Haven, CT, USA

    John M. Morton

  4. Bariatric Surgery, Metabolic and Bariatric Care, CHI Memorial Hospital, Chattanooga, TN, USA

    Jaime Ponce

  5. Department of General Surgery, The Bariatric and Metabolic Institute, Cleveland Clinic Florida, Weston, FL, USA

    Raul J. Rosenthal

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Funes, D.R., Lo Menzo, E., Szomstein, S., Rosenthal, R.J. (2020). Physiological Mechanisms of Bariatric Procedures. In: Nguyen, N., Brethauer, S., Morton, J., Ponce, J., Rosenthal, R. (eds) The ASMBS Textbook of Bariatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-27021-6_5

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