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Computed Tomography pp 347–365Cite as

CT Perfusion Techniques and Applications in Stroke and Cancer

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Abstract

CT perfusion is a functional imaging modality that has gained increasing use in imaging acute ischemic stroke patients to select patients for appropriate treatment with either thrombolysis or thrombectomy and in imaging cancer to confirm diagnosis and monitor progress of treatment. The advantages of CT perfusion are around-the-clock accessibility and easy implementation in most imaging departments. The discussion in this chapter will focus on four areas: (1) physiological models of contrast transport in tissue, (2) deconvolution techniques to derive functional parameters from the physiological models, (3) optimization of scanning protocols with respect to radiation dose and accuracy of derived functional parameters, and (4) application examples in stroke and cancer.

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Authors and Affiliations

  1. Imaging Program, Lawson Health Research Institute & Robarts Research Institute, Medical Biophysics, Medical Imaging and Oncology, The University of Western Ontario, London, ON, Canada

    Ting-Yim Lee

  2. Medical Biophysics, The University of Western Ontario, London, ON, Canada

    Dae Myoung Yang, Fiona Li & Raanan Marants

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  1. Ting-Yim Lee
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  2. Dae Myoung Yang
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Correspondence to Ting-Yim Lee .

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Editors and Affiliations

  1. Department of Radiology, Duke University, Durham, NC, USA

    Ehsan Samei

  2. Department of Bioengineering and Radiology, Stanford University, Stanford, CA, USA

    Norbert J. Pelc

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Lee, TY., Yang, D.M., Li, F., Marants, R. (2020). CT Perfusion Techniques and Applications in Stroke and Cancer. In: Samei, E., Pelc, N. (eds) Computed Tomography . Springer, Cham. https://doi.org/10.1007/978-3-030-26957-9_19

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