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Biological Aspects of Endoplasmic Reticulum Stress in Ferroptosis

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Ferroptosis in Health and Disease

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Abstract

Since its discovery in 2012, ferroptosis has been well characterized as an iron-dependent regulated form of cell death caused by the accumulation of lipid-based reactive oxygen species. The endoplasmic reticulum (ER) stress response is one of the interesting biological events in ferroptosis. Recent studies reveal that the ferroptotic agent-induced ER stress response plays an important role in the crosstalk between ferroptosis and apoptosis. This chapter presents the current state of knowledge on the ferroptotic agent-induced ER stress response and its role in the crosstalk between ferroptosis and other types of cell death.

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Acknowledgments

We thank Christine Burr (Department of Surgery, University of Pittsburgh) for her critical review of the manuscript.

Grant Support

This work was supported by the following grants: NCI grants R03 CA205267 and R03 CA212125.

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Authors and Affiliations

  1. Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Young-Sun Lee & Yong J. Lee

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  1. Young-Sun Lee
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  2. Yong J. Lee
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Correspondence to Yong J. Lee .

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  1. Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA

    Daolin Tang

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Lee, YS., Lee, Y.J. (2019). Biological Aspects of Endoplasmic Reticulum Stress in Ferroptosis. In: Tang, D. (eds) Ferroptosis in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-26780-3_5

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