Abstract
Ferroptosis is essentially an iron-catalyzed process of excessive lipid peroxidation. This clinically relevant mode of regulated necrosis is highly studied in an attempt to control it. Synthetic lipophilic free radical traps block ferroptosis and are now preclinically explored for their effectiveness to treat degeneration, trauma, and organ injury. Aside from this detrimental pathological role, ferroptosis seems to play a beneficial role in tumor suppression. Recently, induction of ferroptosis has been shown as a promising novel anticancer approach to kill therapy-resistant cells. In this chapter, we review the therapeutic potential of ferroptosis inducers in cancer and further elaborate on the current findings of ferroptosis regulation in cancer.
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Hassannia, B., Vanden Berghe, T. (2019). Ferroptosis in Cancer Disease. In: Tang, D. (eds) Ferroptosis in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-26780-3_17
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