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Circulating MicroRNAs as Potential Biomarkers for Lung Cancer

  • Chapter
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Tumor Liquid Biopsies

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 215))

Abstract

Lung cancer is the number one cause of cancer-related mortality worldwide. To improve disease outcome, it is crucial to implement biomarkers into the clinics which assist physicians in their decisions regarding diagnosis, prognosis, as well as prediction of treatment response. Liquid biopsy offers an opportunity to obtain such biomarkers in a minimal invasive manner by retrieving tumor-derived material from body fluids of the patient. The abundance of circulating microRNAs is known to be altered in disease and has therefore been studied extensively as a cancer biomarker. Circulating microRNAs present a variety of favorable characteristics for application as liquid biopsy-based biomarkers, including their high stability, relatively high abundance, and presence is nearly all body fluids. Although the application of circulating microRNAs for the management of lung cancer has not entered the clinics yet, several studies showed their utility for diagnosis, prognosis, and efficacy prediction of various treatment strategies, including surgery, radio-/chemotherapy, as well as targeted therapy. To compensate for their limited tumor specificity, several microRNAs are frequently combined into microRNA panels. Moreover, the possibility to combine single microRNAs or microRNA panels with tumor imaging or other cancer-specific biomarkers has the potential to increase specificity and sensitivity and could lead to the clinical application of novel multi-marker combinations.

Sabrina Müller and Florian Janke contributed equally to this work.

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Acknowledgements

We thank Sabine Klauck for critical reading of the manuscript and valuable comments.

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Authors and Affiliations

  1. Division Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 460, 69120, Heidelberg, Germany

    Sabrina Müller, Florian Janke, Steffen Dietz & Holger Sültmann

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  1. Sabrina Müller
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  2. Florian Janke
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  3. Steffen Dietz
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  4. Holger Sültmann
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Correspondence to Holger Sültmann .

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  1. Cancéropôle Est , Strasbourg, France

    Florence Schaffner

  2. Institut de Cancérologie de Lorraine, CNRS UMR7039 CRAN, Université de Lorraine, Vandoeuvre-lès-Nancy, France

    Jean-Louis Merlin

  3. Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Lübeck, Germany

    Nikolas von Bubnoff

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Müller, S., Janke, F., Dietz, S., Sültmann, H. (2020). Circulating MicroRNAs as Potential Biomarkers for Lung Cancer. In: Schaffner, F., Merlin, JL., von Bubnoff, N. (eds) Tumor Liquid Biopsies. Recent Results in Cancer Research, vol 215. Springer, Cham. https://doi.org/10.1007/978-3-030-26439-0_16

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