Abstract
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Before the availability of gene therapy, bone marrow transplantation was the only available option for primary immunodeficiency diseases
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This case demonstrates that long-term follow up is required even when grafting is complete, as the complete recovery of cellular immunity and humoral function occurs only in 50–60% of patients
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Although partial immunity function is sufficient to prevent complications for some time, immunodeficiency may develop later in life due to the immunosenescence of the graft
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References
Reisner Y, Kapoor N, Kirkpatrick D, Pollack MS, Cunningham-Rundles S, Dupont B, Hodes MZ, Good RA, O’Reilly RJ. Transplantation for severe combined immunodeficiency with HLA-A,B,D,DR incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells. Blood. 1983;61(2):341–8.
Orange JS, Ballow M, Stiehm ER, Ballas ZK, Chinen J, De La Morena M, Kumararatne D, Harville TO, Hesterberg P, Koleilat M, McGhee S, Perez EE, Raasch J, Scherzer R, Schroeder H, Seroogy C, Huissoon A, Sorensen RU, Katial R. Use and interpretation of diagnostic vaccination in primary immunodeficiency: a working group report of the basic and clinical immunology interest section of the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. 2012;130(3 Suppl):S1–24.
Bonilla FA, Barlan I, Chapel H, Costa-Carvalho BT, Cunningham-Rundles C, de la Morena MT, Espinosa-Rosales FJ, Hammarstrom L, Nonoyama S, Quinti I, Routes JM, Tang ML, Warnatz K. International consensus document (ICON): common variable immunodeficiency disorders. J Allergy Clin Immunol Pract. 2016;4(1):38–59.
Ting SS, Tangye SG, Wood J, Ffrench RA, Ziegler JB. Reduced memory B-cell populations in boys with B-cell dysfunction after bone marrow transplantation for X-linked severe combined immunodeficiency. Br J Haematol. 2001;112(4):1004–11.
Agarwal S, Busse PJ. Innate and adaptive immunosenescence. Ann Allergy Asthma Immunol. 2010;104(3):183–90. quiz 90–2, 210
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Dieli-Crimi, R., Español, T. (2020). Follow-Up of a Severe Combined Immunodeficiency, Who Received Bone-Marrow Transplantation Four Decades Ago. In: Rahmani, F., Rezaei, N. (eds) Pediatric Autoimmunity and Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-26280-8_44
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DOI: https://doi.org/10.1007/978-3-030-26280-8_44
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