Abstract
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Linkage disequilibrium is the concept that HLA types are associated into inherited haplotypes more commonly than is expected from DNA crossover events, which occur during normal meiosis
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The distal HLA loci HLA-DP and HLA-A may have some of the greatest chances to undergo crossover exchanges, due to being at the opposite extreme ends of the HLA locus on the short arm of chromosome six
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If the HLA-A, -B, -C, and -DR are known, then -DQ can be predicted with reasonable accuracy, and likewise if HLA-A, -B, -C, -DR, and -DQ are known, the -DP may be predicted, albeit with somewhat less accuracy
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References
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Pandey, S., Harville, T. (2020). Linkage Disequilibrium Between HLA Alleles in Hematopoietic Stem Cell Transplantation. In: Rahmani, F., Rezaei, N. (eds) Pediatric Autoimmunity and Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-26280-8_39
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DOI: https://doi.org/10.1007/978-3-030-26280-8_39
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