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A Research Wish List to Understand, Diagnose, and Manage Frailty and Sarcopenia

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Frailty and Sarcopenia in Cirrhosis
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Abstract

Loss of muscle mass and function in advanced liver disease has become a topic of rapidly growing interest since reports relating frailty and sarcopenia to risk of adverse liver transplant outcomes began to appear 7 years ago. Our current rapid growth in understanding of the problem has allowed the emergence of robust new opportunities for basic and clinical research that promise to improve the outcomes and quality of life of patients with cirrhosis.

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References

  1. Patel VC, White H, Støy S, et al. Clinical science workshop: targeting the gut-liver-brain axis. Metab Brain Dis. 2016;31:1327–37.

    Article  Google Scholar 

  2. Bhanji RA, Narayanan P, Allen AM, et al. Sarcopenia in hiding: the risk and consequence of underestimating muscle dysfunction in NASH. Hepatology. 2017;66:2055–65.

    Article  CAS  Google Scholar 

  3. Simon L, Jolley SE, Molina PE. Alcoholic myopathy: pathophysiologic mechanisms and clinical implications. Alcohol Res. 2017;38:207–17.

    PubMed  PubMed Central  Google Scholar 

  4. Acharya C, Bajaj JS. The microbiome in cirrhosis and its complications. Clin Gastroenterol Hepatol. 2019;17:307–21.

    Google Scholar 

  5. Ticinesi A, Lauretani F, Milani C, et al. Aging gut microbiota at the cross-road between nutrition, physical frailty, and sarcopenia: is there a gut–muscle axis? Nutrients. 2017;9:1303.

    Article  Google Scholar 

  6. Reiberger T, Mandorfer M. Beta adrenergic blockade and decompensated cirrhosis. J Hepatol. 2017;66:849–59.

    Article  CAS  Google Scholar 

  7. Jacobson GA, Fawcett JP. Beta2-agonist doping control and optical isomer challenges. Sports Med. 2016;46:1787–95.

    Article  Google Scholar 

  8. Kandilis AN, Papadopoulou IP, Koskinas J, et al. Liver innervation and hepatic function: new insights. J Surg Res. 2015;194:511–9.

    Article  CAS  Google Scholar 

  9. Dasarathy S, Hatzgolou M. Hyperammonemia and proteostasis in cirrhosis. Curr Opin Clin Nutr Metab Care. 2018;21:30–6.

    Article  CAS  Google Scholar 

  10. Davuluri G, Krowkowski D, Guan BJ, et al. Metabolic adaptation of skeletal muscle to hyperammonemia drives the beneficial effects of L-leucine in cirrhosis. J Hepatol. 2016;65:929–37.

    Article  CAS  Google Scholar 

  11. Carey EJ, Lai JC, Wang CW, et al. A multicenter study to define sarcopenia in patients with end-stage liver disease. Liver Transpl. 2017;23:625–33.

    Article  Google Scholar 

  12. Lai JC, Covinsky KE, Dodge JL, et al. Development of a novel frailty index to predict mortality in patients with end-stage liver disease. Hepatology. 2017;66:564–74.

    Article  Google Scholar 

  13. Dunn MA, Josbeno DA, Schmotzer AR, et al. The gap between clinically assessed physical performance and objective physical activity in liver transplant candidates. Liver Transpl. 2016;22:1324–32.

    Article  Google Scholar 

  14. Cawthon PM, Orwoll ES, Peters KE, et al. Strong relation between muscle mass determined by D3-creatine dilution, physical performance and incidence of falls and mobility limitations in a prospective cohort of older men. J Gerontol A Biol Sci Med Sci. 2019;74(6):844–52.

    Article  Google Scholar 

  15. Carey EJ, Steidley DE, Aqel BA, et al. Six-minute walk distance predicts mortality in liver transplant candidates. Liver Transpl. 2010;16:1373–8.

    Article  Google Scholar 

  16. Berzigotti A, Albillos A, Villanueva C, et al. Effects of an intensive lifestyle intervention program on portal hypertension in patients with cirrhosis and obesity: the SportDiet study. Hepatology. 2017;65:1293–305.

    Article  Google Scholar 

  17. Lai JC, Segev DL, McCulloch CE, et al. Physical frailty after liver transplantation. Am J Transplant. 2018;18:1986–94.

    Article  Google Scholar 

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Correspondence to Michael A. Dunn .

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Dunn, M.A. (2020). A Research Wish List to Understand, Diagnose, and Manage Frailty and Sarcopenia. In: Tandon, P., Montano-Loza, A. (eds) Frailty and Sarcopenia in Cirrhosis. Springer, Cham. https://doi.org/10.1007/978-3-030-26226-6_18

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  • DOI: https://doi.org/10.1007/978-3-030-26226-6_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-26225-9

  • Online ISBN: 978-3-030-26226-6

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