Abstracts
Frailty and sarcopenia are important domains of patient assessment that are recognized as influencing waitlist and transplant outcomes among liver transplant candidates. These distinct but complementary concepts both require accurate and reproducible measurement to quantify patient risk and direct at-risk patients to interventions to mitigate the impact of frailty and sarcopenia. Prehabilitation protocols, guided by frailty and sarcopenia measures, may allow patients to optimize survival on the waiting list and prevent complications after transplant.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Carey EJ, Lai JC, Wang CW, Dasarathy S, Lobach I, Montano-Loza AJ, et al. A multicenter study to define sarcopenia in patients with end-stage liver disease. Liver Transpl. 2017;23(5):625–33.
Carey EJ, Lai JC, Sonnenday C, Tapper EB, Tandon P, Duarte-Rojo A, et al. A North American expert opinion statement on sarcopenia in liver transplantation. Hepatology. John Wiley & Sons, Ltd; 2019.
Englesbe MJ, Patel SP, He K, Lynch RJ, Schaubel DE, Harbaugh C, et al. Sarcopenia and mortality after liver transplantation. J Am Coll Surg. 2010;211(2):271–8.
Lai JC, Feng S, Terrault NA, Lizaola B, Hayssen H, Covinsky K. Frailty predicts waitlist mortality in liver transplant candidates. Am J Transplant. 2014;14(8):1870–9.
Lai JC, Covinsky KE, McCulloch CE, Feng S. The liver frailty index improves mortality prediction of the subjective clinician assessment in patients with cirrhosis. Am J Gastroenterol. 2018;113(2):235–42.
Lai JC, Sonnenday CJ, Tapper EB, Duarte-Rojo A, Dunn MA, Bernal W, et al. Frailty in liver transplantation: an expert opinion statement from the American Society of Transplantation Liver and Intestinal Community of Practice. Am J Transplant. John Wiley & Sons, Ltd (10.1111). 2019;111(12):1776.
Mathur S, Janaudis-Ferreira T, Wickerson L, Singer LG, Patcai J, Rozenberg D, et al. Meeting report: consensus recommendations for a research agenda in exercise in solid organ transplantation. Am J Transplant. John Wiley & Sons, Ltd (10.1111). 2014;14:2235–45.
Montano-Loza AJ, Meza-Junco J, Baracos VE, Prado CMM, Ma M, Meeberg G, et al. Severe muscle depletion predicts postoperative length of stay but is not associated with survival after liver transplantation. Liver Transpl. 2014;20(6):640–8.
Waits SA, Englesbe MJ. Making progress toward frailty remediation in end-stage liver disease. Transplantation. 2016;100(12):2526.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Sonnenday, C.J. (2020). Frailty and Sarcopenia in the Selection of Candidates for Liver Transplantation. In: Tandon, P., Montano-Loza, A. (eds) Frailty and Sarcopenia in Cirrhosis. Springer, Cham. https://doi.org/10.1007/978-3-030-26226-6_12
Download citation
DOI: https://doi.org/10.1007/978-3-030-26226-6_12
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-26225-9
Online ISBN: 978-3-030-26226-6
eBook Packages: MedicineMedicine (R0)