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The Tear Film: Pathological Conditions

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Ocular Fluid Dynamics

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Abstract

This chapter first reviews the pathogenesis of dry eye (DE) and the pathological effects DE has on the properties and composition of the tear film, lacrimal and meibomian glands, and goblet cells. Next, the pathologic changes that occur with two DE related risk factors: aging and the use of glaucoma eye drops are discussed. Finally, the clinical consequences of tear film, lacrimal gland, meibomian gland, and goblet cell alterations, focusing on visual function, nerve modulation, quality of life, and economic burden, are explored.

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Funding

This work was supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research EPID-006-15S (Dr. Galor), NIH Center Core Grant P30EY014801, R01EY026174 (Dr. Galor), Research to Prevent Blindness Unrestricted Grant.

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Authors and Affiliations

  1. Miami Veterans Administration Medical Center, Miami, FL, USA

    Vikram Paranjpe & Anat Galor

  2. Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA

    Vikram Paranjpe & Anat Galor

Authors
  1. Vikram Paranjpe
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  2. Anat Galor
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Correspondence to Anat Galor .

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Editors and Affiliations

  1. Department of Math Sciences, Indiana University – Purdue University I, Indianapolis, IN, USA

    Giovanna Guidoboni

  2. Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Alon Harris

  3. Department of Mathematics, Polytechnic University of Milan, Milan, Italy

    Riccardo Sacco

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Paranjpe, V., Galor, A. (2019). The Tear Film: Pathological Conditions. In: Guidoboni, G., Harris, A., Sacco, R. (eds) Ocular Fluid Dynamics. Modeling and Simulation in Science, Engineering and Technology. Birkhäuser, Cham. https://doi.org/10.1007/978-3-030-25886-3_15

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