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Anticoagulation in Pregnancy and Lactation

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Abstract

Pregnant women and those in the postpartum period are at an increased risk for the development of thromboembolic complications compared to non-pregnant ladies. The current chapter addresses the risk stratification during and following pregnancy and the methods of thromboprophylaxis as well as the therapeutic approach to treat established venous thromboembolism in this vulnerable population.

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Abbreviations

ART:

Assisted reproductive technology

ASH:

American Society of Hematology

BMI:

Body mass index

CTPA:

Computerized tomography pulmonary arteriography

DOACs:

Direct oral anticoagulants

DVT:

Deep vein thrombosis

HIT:

Heparin-induced thrombocytopenia

IBD:

Inflammatory bowel disease

IVF:

In vitro fertilization

LMWH:

Low-molecular-weight heparin

OHSS:

Ovarian hyper-stimulation syndrome

PE:

Pulmonary embolism

RCOG:

Royal College of Obstetricians and Gynaecologists

SC:

Subcutaneous

SLE:

Systemic lupus erythematosus

SOGC:

Society of Obstetricians and Gynaecologists of Canada

UFH:

Unfractionated heparin

V/Q scan:

Ventilation/perfusion scan

VTE:

Venous thromboembolism

References

  1. ACOG Practice Bulletin No. 196: Thromboembolism in pregnancy. Obstet Gynecol. 2018;132(1):e1–e17. https://doi.org/10.1097/AOG.0000000000002706.

  2. Royal College of Obstetricians and Gynaecologists. Reducing the risk of venous thromboembolism during pregnancy and the puerperium. Green-top guideline no. 37a, Guidelines of the Royal College of Obstetricians and Gynaecologists of the UK, April 2015. p. 1–40.

    Google Scholar 

  3. Bates SM, Rajasekhar A, Middeldorp S, McLintock C, Rodger MA, James AH, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy. Blood Adv. 2018;2:3317–59.

    Article  CAS  Google Scholar 

  4. Pregnancy: thromboprophylaxis. Thrombosis Canada Guidelines, 2017.

    Google Scholar 

  5. Akinshina S, Makatsariya A, Bitsadze V, Khizroeva J, Khamani N. Thromboprophylaxis in pregnant women with thrombophilia and a history of thrombosis. J Perinat Med. 2018;46(8):893–9. https://doi.org/10.1515/jpm-2017-0329.

    Article  CAS  PubMed  Google Scholar 

  6. Chan WS, Rey E, Kent NE, VTE in Pregnancy Guideline Working Group, Chan WS, Kent NE, Rey E, Corbett T, David M, Douglas MJ, Gibson PS, Magee L, Rodger M, Smith RE, Society of Obstetricians and Gynecologists of Canada. Venous thromboembolism and antithrombotic therapy in pregnancy: SOGC Clinical Practice Guideline. J Obstet Gynaecol Can. 2014;36(6):527–53.

    Article  Google Scholar 

  7. Royal College of Obstetricians and Gynaecologists. Thromboembolic disease in pregnancy and the puerperium: acute management. Green-top guideline no. 37b, Guidelines of the Royal College of Obstetricians and Gynaecologists of the UK, April 2015. p. 1–32.

    Google Scholar 

  8. Cushman M, Wendy Lim W, Zakai N. 2011 Clinical practice guide on anticoagulant dosing and management of anticoagulant associated bleeding complications in adults. Presented by the American Society of Hematology, adapted in part from the: American College of Chest Physicians Evidence-Based Clinical Practice Guideline on Antithrombotic and Thrombolytic Therapy. Quick Reference, 2011.

    Google Scholar 

  9. van Mens TE, Scheres LJ, de Jong PG, Leeflang MM, Nijkeuter M, Middeldorp S. Imaging for the exclusion of pulmonary embolism in pregnancy. Cochrane Database Syst Rev. 2017;1:CD011053.

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Saskatoon Cancer Centre, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada

    Otto Moodley, Derek Pearson & Hadi Goubran

Authors
  1. Otto Moodley
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  2. Derek Pearson
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  3. Hadi Goubran
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Corresponding author

Correspondence to Otto Moodley .

Editor information

Editors and Affiliations

  1. Saskatoon Cancer Centre College of Medicine University of Saskatchewan, Saskatoon, SK, Canada

    Hadi Goubran

  2. Faculty of Medicine Cairo University, Giza, Egypt

    Gaafar Ragab

  3. College of Human Medicine Michigan State University, East Lansing, MI, USA

    Suzy Hassouna

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Moodley, O., Pearson, D., Goubran, H. (2020). Anticoagulation in Pregnancy and Lactation. In: Goubran, H., Ragab, G., Hassouna, S. (eds) Precision Anticoagulation Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-25782-8_6

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  • DOI: https://doi.org/10.1007/978-3-030-25782-8_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-25781-1

  • Online ISBN: 978-3-030-25782-8

  • eBook Packages: MedicineMedicine (R0)

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