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A 40-Year-Old Woman with Patchy Painful Paresthesia

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A Case-Based Guide to Neuromuscular Pathology

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Abstract

Small fiber neuropathy (SFN) is a common neuromuscular disorder which can be associated with many medical conditions. While the majority of SFN is length-dependent (LD-SFN), non-length-dependent SFN (NLD-SFN) is frequently seen in association with sarcoidosis, Sjogren’s syndrome, and other immune-mediated conditions. Comparing with LD-SFN, the age at onset in NLD-SFN is younger and it more affects woman. Skin biopsy shows reduced intraepidermal nerve fiber densities with no distal-to-proximal gradient. Here we describe a case of NLD-SFN associated with sarcoidosis.

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Author information

Authors and Affiliations

  1. Departments of Neurology and Pathology, Boston University Medical Center, Boston, MA, USA

    Lan Zhou

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  1. Lan Zhou
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Correspondence to Lan Zhou .

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Editors and Affiliations

  1. Departments of Neurology and Pathology, Boston University Medical Center, Boston, MA, USA

    Lan Zhou

  2. Department of Pathology, Neuropathology Section, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Dennis K. Burns

  3. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Chunyu Cai

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Zhou, L. (2020). A 40-Year-Old Woman with Patchy Painful Paresthesia. In: Zhou, L., Burns, D., Cai, C. (eds) A Case-Based Guide to Neuromuscular Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-25682-1_40

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  • DOI: https://doi.org/10.1007/978-3-030-25682-1_40

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-25681-4

  • Online ISBN: 978-3-030-25682-1

  • eBook Packages: MedicineMedicine (R0)

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