Abstract
We describe a case of primary neurolymphomatosis (PNL) with unusual presentation of a right lumbosacral polyradiculoneuropathy with no other lesions shown on the whole body fludeoxyglucose-positron emission tomography (FDG-PET) scan. A right superficial peroneal nerve lesion biopsy revealed infiltration of the nerve by malignant CD20+ lymphoma cells. The lymphoma cells expressed Bcl-2 but not CD10, suggesting an origin in peripheral blood not lymph nodes. The patient responded very well to the combined radiotherapy and chemotherapy with the R-MPV (rituximab, methotrexate, procarbazine, and vincristine) regimen. The patient showed marked clinical improvement and complete resolution of lymphoma lesions on the PET scan.
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Zhou, L., Morgello, S., Motiwala, R., Shin, S.C. (2020). A 64-Year-Old Woman with Progressive Pain, Numbness and Weakness in the Right Lower Limb. In: Zhou, L., Burns, D., Cai, C. (eds) A Case-Based Guide to Neuromuscular Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-25682-1_37
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DOI: https://doi.org/10.1007/978-3-030-25682-1_37
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