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The Impact of Herbal Products in the Prevention, Regeneration and Delay of Skin Aging

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Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1178))

Abstract

Skin aging is a complex process induced by intrinsic and extrinsic factors and causes alterations to the structural and functional aspects of the skin. Skin aging affects patients physically and physiologically. Understanding the process of skin aging can provide new knowledge on how to attenuate or reduce skin disorder symptoms. Herbs have been used for ages to prevent and treat skin aging, yet there are growing interests by researchers in this field globally. Various strategies have been developed for improving the quality and effectivity of herbal skin care products, both for topical and oral applications. This review will provide an overview of the relationship between herbal skin care products and the skin aging process.

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References

  1. Pérez-Sánchez A, Barrajón-Catalán E, Herranz-López M, Micol V (2018) Nutraceuticals for skin care: a comprehensive review of human clinical studies. Nutrients 10(4). pii: E403. https://doi.org/10.3390/nu10040403

    Article  PubMed Central  CAS  Google Scholar 

  2. Blanpain C, Fuchs E (2006) Epidermal stem cells of the skin. Annu Rev Cell Dev Biol 22:339–373

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Zhang S, Duan E (2018) Fighting against skin aging: the way from bench to bedside. Cell Transplant 27(5):729–738

    Article  PubMed  PubMed Central  Google Scholar 

  4. Rinnerthaler M, Bischof J, Streubel MK, Trost A, Richter K (2015) Oxidative stress in aging human skin. Biomol Ther 5(2):545–589

    CAS  Google Scholar 

  5. Ahsanuddin S, Lam M, Baron ED (2016) Skin aging and oxidative stress. AIMS Mol Sci 3(2):187–195

    Article  CAS  Google Scholar 

  6. Tu Y, Quan T (2016) Oxidative stress and human skin connective tissue aging. Cosmetics 3(3):28. https://doi.org/10.3390/cosmetics3030028

    Article  CAS  Google Scholar 

  7. Helfrich YR, Sachs DL, Voorhees JJ (2008) Overview of skin aging and photoaging. Dermatol Nurs 20(3):177–183; quiz 184

    PubMed  Google Scholar 

  8. Kazanci A, Kurus M, Atasever A (2017) Analyses of changes on skin by aging. Skin Res Technol 23(1):48–60

    Article  CAS  PubMed  Google Scholar 

  9. Oliveira BF, Nogueira-Machado JA, Chaves MM (2010) The role of oxidative stress in the aging process. ScientificWorldJournal 10:1121–1128

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Avantaggiato A, Bertuzzi G, Pascali M, Candotto V, Carinci F (2015) The theories of aging: reactive oxygen species and what else? J Biol Regul Homeost Agents 29(3 Suppl 1):156–163

    CAS  PubMed  Google Scholar 

  11. Jadoon S, Karim S, Bin Asad MH, Akram MR, Khan AK, Malik A et al (2015) Anti-aging potential of phytoextract loaded-pharmaceutical creams for human skin cell longetivity. Oxidative Med Cell Longev 2015:709628. https://doi.org/10.1155/2015/709628

    Article  CAS  Google Scholar 

  12. Bulla MK, Hernandes L, Baesso ML, Nogueira AC, Bento AC, Bortoluzzi BB et al (2015) Evaluation of photoprotective potential and percutaneous penetration by photoacoustic spectroscopy of the Schinus terebinthifolius raddi extract. Photochem Photobiol 91(3):558–566

    Article  CAS  PubMed  Google Scholar 

  13. Almeida IF, Pinto AS, Monteiro C, Monteiro H, Belo L, Fernandes J et al (2015) Protective effect of C. sativa leaf extract against UV mediated-DNA damage in a human keratinocyte cell line. J Photochem Photobiol B 144:28–34

    Article  CAS  PubMed  Google Scholar 

  14. Shin SW, Jung E, Kim S, Kim JH, Kim EG, Lee J et al (2013) Antagonizing effects and mechanisms of afzelin against UVB-induced cell damage. PLoS One 8(4):e61971. https://doi.org/10.1371/journal.pone.0061971

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Shin SW, Jung E, Kim S, Lee KE, Youm JK, Park D (2013) Antagonist effects of veratric acid against UVB-induced cell damages. Molecules 18(5):5405–5419

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Dudonné S, Poupard P, Coutière P, Woillez M, Richard T, Mérillon JM et al (2011) Phenolic composition and antioxidant properties of poplar bud (Populus nigra) extract: individual antioxidant contribution of phenolics and transcriptional effect on skin aging. J Agric Food Chem 59(9):4527–4536

    Article  PubMed  CAS  Google Scholar 

  17. Fujii T, Wakaizumi M, Ikami T, Saito M (2008) Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblasts. J Ethnopharmacol 119(1):53–57

    Article  PubMed  Google Scholar 

  18. Chao HC, Najjaa H, Villareal MO, Ksouri R, Han J, Neffati M et al (2013) Arthrophytum scoparium inhibits melanogenesis through the down-regulation of tyrosinase and melanogenic gene expressions in B16 melanoma cells. Exp Dermatol 22(2):131–136

    Article  CAS  PubMed  Google Scholar 

  19. Allemann IB, Baumann L (2009) Botanicals in skin care products. Int J Dermatol 48(9):923–934

    Article  CAS  PubMed  Google Scholar 

  20. Kraft JN, Lynde CW (2005) Moisturizers: what they are and a practical approach to product selection. Skin Therapy Lett 10(5):1–8

    CAS  PubMed  Google Scholar 

  21. Makrantonaki E, Zouboulis CC (2007) Molecular mechanisms of skin aging: state of the art. Ann N Y Acad Sci 1119:40–50

    Article  CAS  PubMed  Google Scholar 

  22. El-Domyati M, Attia S, Saleh F, Brown D, Birk DE, Gasparro F et al (2002) Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin. Exp Dermatol 11(5):398–405

    Article  CAS  PubMed  Google Scholar 

  23. Tobin DJ (2017) Introduction to skin aging. J Tissue Viability 26(1):37–46

    Article  PubMed  Google Scholar 

  24. Baumann L (2018) How to use oral and topical cosmeceuticals to prevent and treat skin aging. Facial Plast Surg Clin North Am 26(4):407–413

    Article  PubMed  Google Scholar 

  25. Kusumawati I, Kurniawan KO, Rullyansyah S, Prijo TA, Widyowati R, Ekowati J et al (2018) Anti-aging properties of Curcuma heyneana Valeton & Zipj: a scientific approach to its use in Javanese tradition. J Ethnopharmacol 225:64–70

    Article  CAS  PubMed  Google Scholar 

  26. Stearns HC, Sneeden VD (1966) Observations on the clinical and pathologic aspects of the pelvic congestion syndrome. Am J Obstet Gynecol 94(5):718–732

    Article  CAS  PubMed  Google Scholar 

  27. Costin GE, Hearing VJ (2007) Human skin pigmentation: melanocytes modulate skin color in response to stress. FASEB J 21(4):976–994

    Article  CAS  PubMed  Google Scholar 

  28. Lorencini M, Brohem CA, Dieamant GC, Zanchin NI, Maibach HI (2014) Active ingredients against human epidermal aging. Ageing Res Rev 15:100–115

    Article  CAS  PubMed  Google Scholar 

  29. Farage MA, Miller KW, Elsner P, Maibach HI (2013) Characteristics of the aging skin. Adv Wound Care (New Rochelle) 2(1):5–10

    Article  Google Scholar 

  30. Calleja-Agius J, Muscat-Baron Y, Brincat MP (2007) Skin ageing. Menopause Int 13(2):60–64

    Article  CAS  PubMed  Google Scholar 

  31. Baumann L (2007) Skin ageing and its treatment. J Pathol 211(2):241–251

    Article  CAS  PubMed  Google Scholar 

  32. Rittié L, Fisher GJ (2002) UV-light-induced signal cascades and skin aging. Ageing Res Rev 1(4):705–720

    Article  PubMed  Google Scholar 

  33. Elsner P, Maibach HI (2005) Cosmeceuticals and active cosmetics: drugs versus cosmetics. Taylor & Francis, Boca Raton. ASIN: B01K0U81P0

    Google Scholar 

  34. Sakai S, Yasuda R, Sayo T, Ishikawa O, Inoue S (2000) Hyaluronan exists in the normal stratum corneum. J Invest Dermatol 114(6):1184–1187

    Article  CAS  PubMed  Google Scholar 

  35. Bentov I, Reed MJ (2015) The effect of aging on the cutaneous microvasculature. Microvasc Res 100:25–31

    Article  PubMed  PubMed Central  Google Scholar 

  36. Rittié L, Fisher GJ (2015) Natural and sun-induced aging of human skin. Cold Spring Harb Perspect Med 5(1):a015370. https://doi.org/10.1101/cshperspect.a015370

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Rohrich RJ, Pessa JE (2008) The retaining system of the face: histologic evaluation of the septal boundaries of the subcutaneous fat compartments. Plast Reconstr Surg 121(5):1804–1809

    Article  CAS  PubMed  Google Scholar 

  38. Hughes MC, Williams GM, Baker P, Green AC (2013) Sunscreen and prevention of skin aging: a randomized trial. Ann Intern Med 158(11):781–790

    Article  PubMed  Google Scholar 

  39. Guo WJ, Datta S, Band V, Dimri GP (2007) Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins. Mol Biol Cell 18(2):536–546

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Kim EJ, Kim YK, Kim JE, Kim S, Kim MK, Park CH et al (2011) UV modulation of subcutaneous fat metabolism. J Invest Dermatol 131(8):1720–1726

    Article  CAS  PubMed  Google Scholar 

  41. Sepe A, Tchkonia T, Thomou T, Zamboni M, Kirkland JL (2011) Aging and regional differences in fat cell progenitors - a mini-review. Gerontology 57(1):66–75

    Article  PubMed  Google Scholar 

  42. Stojiljković D, Pavlović D, Arsić I (2014) Oxidative stress, skin aging and antioxidant therapy. Acta Fac Medicae Naissensis 31(4):207–217

    Article  CAS  Google Scholar 

  43. Petruk G, Del Giudice R, Rigano MM, Monti DM (2018) Antioxidants from plants protect against skin photoaging. Oxidative Med Cell Longev 2018:1454936–1454911. https://doi.org/10.1155/2018/1454936

    Article  CAS  Google Scholar 

  44. Kusumawati I, Indrayanto G (2013) Natural antioxidants in cosmetics. In: Atta-ur-Rahman (ed) Studies in natural products chemistry, vol 40, 40th ed, pp 485–505. Elsevier; Amsterdam, Netherlands. ISBN-10: 0444596038

    Google Scholar 

  45. Simo A, Kawal N, Paliyath G, Bakovic M (2014) Botanical antioxidants for skin health in the world of cosmeceuticals. Int J Adv Nutr Health Sci 2(1):67–88

    Article  Google Scholar 

  46. Kasote DM, Katyare SS, Hegde MV, Bae H (2015) Significance of antioxidant potential of plants and its relevance to therapeutic applications. Int J Biol Sci 11(8):982–991

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Zduńska K, Dana A, Kolodziejczak A, Rotsztejn H (2018) Antioxidant properties of ferulic acid and its possible application. Skin Pharmacol Physiol 31(6):332–336

    Article  PubMed  CAS  Google Scholar 

  48. Gilaberte Y, González S (2007) Update on photoprotection. Actas Dermosifiliogr 101(8):659–672

    Article  Google Scholar 

  49. Liang Y, Wu M, Chen Y (2019) Selected medicinal herbs and functional peptides for protection against photoaging of the skin. J Cosmet Dermatological Sci Appl 9(1):1–18

    Google Scholar 

  50. Kullavanijaya P, Lim HW (2005) Photoprotection. J Am Acad Dermatol 52(6):937–958

    Article  PubMed  Google Scholar 

  51. DeBuys HV, Levy SB, Murray JC, Madey DL, Pinnell SR (2000) Modern approaches to photoprotection. Dermatol Clin 18(4):577–590

    Article  CAS  PubMed  Google Scholar 

  52. Nash JF (2006) Human safety and efficacy of ultraviolet filters and sunscreen products. Dermatol Clin 24(1):35–51

    Article  CAS  PubMed  Google Scholar 

  53. Fourtanier A, Moyal D, Seité S (2008) Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results. Photodermatol Photoimmunol Photomed 24(4):164–174

    Article  CAS  PubMed  Google Scholar 

  54. Wölfle U, Esser PR, Simon-Haarhaus B, Martin SF, Lademann J, Schempp CM (2011) UVB-induced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo. Free Radic Biol Med 50(9):1081–1093

    Article  PubMed  CAS  Google Scholar 

  55. Koster MI (2009) Making an epidermis. Ann N Y Acad Sci 1170:7–10

    Article  PubMed  PubMed Central  Google Scholar 

  56. Wittenauer J, Mäckle S, Sußmann D, Schweiggert-Weisz U, Carle R (2015) Inhibitory effects of polyphenols from grape pomace extract on collagenase and elastase activity. Fitoterapia 101:179–187

    Article  CAS  PubMed  Google Scholar 

  57. Chowdhury A, Sarkar J, Chakraborti T, Chakraborti S (2015) Role of Spm-Cer-S1P signalling pathway in MMP-2 mediated U46619-induced proliferation of pulmonary artery smooth muscle cells: protective role of epigallocatechin-3-gallate. Cell Biochem Funct 33(7):463–477

    Article  CAS  PubMed  Google Scholar 

  58. Hah YS, Cho HY, Lim TY, Park DH, Kim HM, Yoon J et al (2012) Induction of melanogenesis by rapamycin in human MNT-1 melanoma cells. Ann Dermatol 24(2):151–157

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Liu WS, Kuan YD, Chiu KH, Wang WK, Chang FH, Liu CH et al (2013) The extract of Rhodobacter sphaeroides inhibits melanogenesis through the MEK/ERK signaling pathway. Mar Drugs 11(6):1899–1908

    Article  PubMed  PubMed Central  Google Scholar 

  60. Zucca P, Pintus M, Manzo G, Nieddu M, Steri D, Rinaldi AC (2015) Antimicrobial, antioxidant and anti-tyrosinase properties of extracts of the Mediterranean parasitic plant Cytinus hypocistis. BMC Res Notes 8:562. https://doi.org/10.1186/s13104-015-1546-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Roh HJ, Noh HJ, Na CS, Kim CS, Kim KH, Hong CY et al (2015) Phenolic compounds from the leaves of Stewartia pseudocamellia maxim. And their whitening activities. Biomol Ther 23(3):283–289

    Article  CAS  Google Scholar 

  62. Sugumaran M (2002) Comparative biochemistry of eumelanogenesis and the protective roles of phenoloxidase and melanin in insects. Pigment Cell Res 15(1):2–9

    Article  CAS  PubMed  Google Scholar 

  63. Boissy RE, Manga P (2004) On the etiology of contact/occupational vitiligo. Pigment Cell Res 17(3):208–214

    Article  CAS  PubMed  Google Scholar 

  64. Mitani K, Takano F, Kawabata T, Allam AE, Ota M, Takahashi T et al (2013) Suppression of melanin synthesis by the phenolic constituents of sappanwood (Caesalpinia sappan). Planta Med 79(1):37–44

    CAS  PubMed  Google Scholar 

  65. Park J, Park JH, Suh HJ, Lee IC, Koh J, Boo YC (2014) Effects of resveratrol, oxyresveratrol, and their acetylated derivatives on cellular melanogenesis. Arch Dermatol Res 306(5):475–487

    Article  CAS  PubMed  Google Scholar 

  66. Kim BH (2010) Safety evaluation and anti-wrinkle effects of retinoids on skin. Toxicol Res 26(1):61–66

    Article  PubMed  PubMed Central  Google Scholar 

  67. Jeong JY, Liu Q, Kim SB, Jo YH, Mo EJ, Yang HH et al (2015) Characterization of melanogenesis inhibitory constituents of Morus alba leaves and optimization of extraction conditions using response surface methodology. Molecules 20(5):8730–8741

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Demirkiran O, Sabudak T, Ozturk M, Topcu G (2013) Antioxidant and tyrosinase inhibitory activities of flavonoids from Trifolium nigrescens Subsp. petrisavi. J Agric Food Chem 61(51):12598–12603

    Article  CAS  PubMed  Google Scholar 

  69. Oricha BS (2010) Cosmeceuticals: a review. Afr J Pharm Pharmacol 4(4):127–129

    CAS  Google Scholar 

  70. Anunciato TP, da Rocha Filho PA (2012) Carotenoids and polyphenols in nutricosmetics, nutraceuticals, and cosmeceuticals. J Cosmet Dermatol 11(1):51–54

    Article  PubMed  Google Scholar 

  71. Kadam Vaishali S, Chintale Ashwini G, Deshmukh Kshitija P, Nalwad Digambar N (2013) Cosmeceuticals an emerging concept: a comprehensive review. Int J Res Pharm Chem 3(2):308–316

    Google Scholar 

  72. Wanjari N, Waghmare J (2015) A review on latest trend of cosmetics-cosmeceuticals. Int J Pharma Res Rev 4(5):45–51

    CAS  Google Scholar 

  73. Millikan LE (2001) Cosmetology, cosmetics, cosmeceuticals: definitions and regulations. Clin Dermatol 19(4):371–374

    Article  CAS  PubMed  Google Scholar 

  74. Bellad KA, Nanjwade BK, Kamble MS, Srichana T, Idris NF (2017) Development of cosmeceuticals. World J Pharm Pharm Sci 6(4):643–691

    CAS  Google Scholar 

  75. Pandel R, Poljšak B, Godic A, Dahmane R (2013) Skin photoaging and the role of antioxidants in its prevention. ISRN Dermatol 2013:930164. https://doi.org/10.1155/2013/930164

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. McCook JP (2016) Topical products for the aging face. Clin Plast Surg 43(3):597–604

    Article  PubMed  Google Scholar 

  77. Shin KO, Park HS (2019) Antiaging cosmeceuticals in Korea and open innovation in the era of the 4th industrial revolution: from research to business. Sustain 11(3):898. https://doi.org/10.3390/su11030898

    Article  Google Scholar 

  78. Hodges AL, Walker DK (2017) Skin care for women. Nurs Womens Health 20(6):609–613

    Article  PubMed  Google Scholar 

  79. Kaul S, Gulati N, Verma D, Mukherjee S, Nagaich U (2018) Role of nanotechnology in cosmeceuticals: a review of recent advances. J Pharm (Cairo) 2018:3420204. https://doi.org/10.1155/2018/3420204

    Article  CAS  Google Scholar 

  80. Alğin Yapar E (2017) Herbal cosmetics and novel drug delivery systems. Indian J Pharm Educ Res 51(3):S152–S158

    Article  CAS  Google Scholar 

  81. Vranesić-Bender D (2010) The role of nutraceuticals in anti-aging medicine. Acta Clin Croat 49(4):537–544

    PubMed  Google Scholar 

  82. Marini A, Krutmann J (2015) Beauty from the inside. In: Neves D (ed) Anti-ageing nutrients: Evidence-Based of Age-Associated Disease, 1st ed, pp 299–314. John Wiley & Sons Ltd; Chicago, USA. ISBN:9781118733271

    Google Scholar 

  83. Ramasubramania Raja R (2016) Nutraceuticals and cosmeceuticals for human beings – an overview. Am J Food Sci Health 2(2):7–17

    Google Scholar 

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Acknowledgements

Idha Kusumawati was supported by an International Research Collaboration and Scientific Publication grant from The Ministries of Research, Technology, and Higher Education, Republic of Indonesia (Grant no. 597/UN3.14/LT/2017), with the project entitled “The Value of Indonesian Herbal Extract as Natural Ingredients and Novel Technologies Anti-Aging”. Special thanks to Dr. Paul C. Guest for the nice picture.

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Warsito, M.F., Kusumawati, I. (2019). The Impact of Herbal Products in the Prevention, Regeneration and Delay of Skin Aging. In: Guest, P. (eds) Reviews on Biomarker Studies in Aging and Anti-Aging Research. Advances in Experimental Medicine and Biology(), vol 1178. Springer, Cham. https://doi.org/10.1007/978-3-030-25650-0_9

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