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From White to Brown – Adipose Tissue Is Critical to the Extended Lifespan and Healthspan of Growth Hormone Mutant Mice

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Reviews on Biomarker Studies in Aging and Anti-Aging Research

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1178))

Abstract

Growth hormone (GH) is a metabolic hormone that has major functions in the liver, muscle, and adipose tissue (AT). In the past 20 years, numerous studies have demonstrated that decreased growth hormone (GH) action is clearly linked to alterations in longevity. Therefore, it is not surprising that mechanisms underlying the extended longevity of GH-mutant animals include alterations in AT function. This Review aims to describe the basics of AT biology, GH secretion and action, and the effects of altered GH signaling in mice and humans. Lastly, this Review discusses the intersection of GH and AT, and how the influence of GH on AT may play a critical role in determining lifespan and healthspan.

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Acknowledgements

We sincerely apologize to those whose work we did not reference due to space limitations or inadvertent omissions. This work was supported by the US National Institutes of Health (NIH) grants DK007260 (to JD), and AG019899 and AG051869 (to AB).

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Authors and Affiliations

  1. Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA

    Justin Darcy

  2. Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, USA

    Andrzej Bartke

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Correspondence to Justin Darcy .

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  1. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Paul C. Guest

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Darcy, J., Bartke, A. (2019). From White to Brown – Adipose Tissue Is Critical to the Extended Lifespan and Healthspan of Growth Hormone Mutant Mice. In: Guest, P. (eds) Reviews on Biomarker Studies in Aging and Anti-Aging Research. Advances in Experimental Medicine and Biology(), vol 1178. Springer, Cham. https://doi.org/10.1007/978-3-030-25650-0_11

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