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Dry Eye Disease: A Modern History

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Foundations of Corneal Disease

Abstract

One of the most common disorders of the ocular surface is dry eye disease (DED). A historical perspective of our understanding of DED can be captured in seven thematic areas. Structure and function of the components of the tear film and ocular surface and the lacrimal functional unit provide the basic information. The hallmarks of DED are tear instability and hyperosmolarity. The role of inflammation in DED and the neurobiological aspects of the ocular surface are important to understanding the vicious cycle of the disease. Recent advances in the diagnosis and treatment of DED provide novel appreciation of DED.

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Author information

Authors and Affiliations

  1. Georgetown University, Department of Ophthalmology, Lake Wales, FL, USA

    Michael A. Lemp

  2. University of Louisville School of Medicine, Department of Ophthalmology and Vision Science, Wilmington, NC, USA

    Gary N. Foulks

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  1. Michael A. Lemp
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  2. Gary N. Foulks
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Editors and Affiliations

  1. Louis Block Professor Chair, Department of Ophthalmology and Visual Science, The University of Chicago Medicine & Biological Sciences, Chicago, IL, USA

    Kathryn Colby

  2. Claes H. Dohlman Professor of Ophthalmology, Harvard Medical School, Cornea & Refractive Surgery, Massachusetts Eye & Ear, Boston, MA, USA

    Reza Dana

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Lemp, M.A., Foulks, G.N. (2020). Dry Eye Disease: A Modern History. In: Colby, K., Dana, R. (eds) Foundations of Corneal Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-25335-6_3

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  • DOI: https://doi.org/10.1007/978-3-030-25335-6_3

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