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Foundations of Corneal Disease pp 249–262Cite as

Corneal Angiogenesis and Lymphangiogenesis

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Abstract

Due to several corneal diseases [1] (Table 21.1) and after surgery [2], blood and lymphatic vessels can grow into the normally avascular cornea. This neovascularization starts for both blood and lymphatic vessels at the limbal vascular plexus. Blood vessels impair significantly the visual function of the cornea due to opacification by blood vessels themselves but also by secondary effects such as oedema and lipid keratopathy in the corneal stroma. Lymphangiogenesis in contrast is visually not disturbing, but a key risk factor for immune reactions after corneal transplantation [3]. Hem- and lymphangiogenesis do not only occur as a consequence of diseases but can also be the reason for infectious or inflammatory corneal diseases. Both hem- and lymphangiogenesis are an essential part of the worldwide most frequent reasons for corneal blindness (trachoma) [4] and the most frequent reason for infectious blindness – herpetic keratitis – in the western civilization [5].

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Acknowledgment

We appreciate support from DFG Research Unit FOR2240 (www.for2240.de), EU Arrest Blindness (www.arrestblindness.eu) and EU Cost Action Biocornea (www.biocornea.eu).

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  1. University of Cologne, Department of Ophthalmology, Cologne, Germany

    Felix Bock & Claus Cursiefen

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  1. Felix Bock
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Correspondence to Claus Cursiefen .

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  1. Louis Block Professor Chair, Department of Ophthalmology and Visual Science, The University of Chicago Medicine & Biological Sciences, Chicago, IL, USA

    Kathryn Colby

  2. Claes H. Dohlman Professor of Ophthalmology, Harvard Medical School, Cornea & Refractive Surgery, Massachusetts Eye & Ear, Boston, MA, USA

    Reza Dana

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Bock, F., Cursiefen, C. (2020). Corneal Angiogenesis and Lymphangiogenesis. In: Colby, K., Dana, R. (eds) Foundations of Corneal Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-25335-6_21

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