Skip to main content

Cooperativity in Neurons–Astrocytes Coupled Dynamics

  • Conference paper
  • First Online:
Extended Abstracts Spring 2018

Part of the book series: Trends in Mathematics ((RPCRMB,volume 11))

  • 426 Accesses

Abstract

Our aim in this article is to study properties of a generalized dynamical system modeling brain lactate kinetics, with N neuron compartments and A astrocyte compartments. In particular, we prove the uniqueness of the stationary point and its asymptotic stability. Furthermore, we check that the system is positive and cooperative.

The first author is very grateful to the CRM, the Dynamical System group of UAB and the organizing committee of the Murphys conference for their invitation and financial support.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. A. Aubert, R. Costalat, Interaction between astrocytes and neurons studied using a mathematical model of compartmentalized energy metabolism. J. Cereb. Blood Flow Metab. 25, 1476–1490 (2005)

    Article  Google Scholar 

  2. R. Costalat, J.P. Françoise, C. Menuel, M. Lahutte, J.N. Vallée, G. de Marco, J. Chiras, R. Guillevin, Mathematical modeling of metabolism and hemodynamics. Acta Biotheor. 60, 99–107 (2012)

    Article  Google Scholar 

  3. R. Guillevin, A. Miranville, A. Perrillat-Mercerot, On a reaction-diffusion system associated with brain lactate kinetics. Electron. J. Differ. Equ. 23, 1–16 (2017)

    Article  MathSciNet  Google Scholar 

  4. J. Keener, J. Sneyd, Mathematical Physiology. Interdisciplinary Applied Mathematics, vol. 8, 2nd edn. (Springer, New York, 2009)

    Google Scholar 

  5. M. Lahutte-Auboin, Modélisation biomathématique du métabolisme énergétique cérébral: réduction de modèle et approche multi-échelle, application à l’aide à la décision pour la pathologie des gliomes, Ph.D. thesis, Université Pierre et Marie Curie (2015)

    Google Scholar 

  6. M. Lahutte-Auboin, R. Costalat, J.P. Françoise, R. Guillevin, Dip and buffering in a fast-slow system associated to brain lactate kinetics. arXiv: 1308.0486v1

  7. M. Lahutte-Auboin, R. Guillevin, J.P. Françoise, J.N. Vallée, R. Costalat, On a minimal model for hemodynamics and metabolism of lactate: application to low grade glioma and therapeutic strategies. Acta Biotheor 61, 79–89 (2013)

    Article  Google Scholar 

  8. A. Miranville, A singular reaction-diffusion equation associated with brain lactate kinetics. Math. Methods Appl. Sci. 40(7), 2452465 (2017)

    Article  MathSciNet  Google Scholar 

  9. H.L. Smith, On the asymptotic behavior of a class of deterministic models of cooperating species. SIAM J. Appl. Math. 46, 368375 (1986)

    MathSciNet  Google Scholar 

  10. H.L. Smith, Monotone dynamical systems: an introduction to the theory of competitive and cooperative systems, in Mathematical Surveys and Monographs. American Mathematical Society, Providence, Rhode Island, USA (1995)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J.-P. Françoise .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Françoise, JP., Ji, H. (2019). Cooperativity in Neurons–Astrocytes Coupled Dynamics. In: Korobeinikov, A., Caubergh, M., Lázaro, T., Sardanyés, J. (eds) Extended Abstracts Spring 2018. Trends in Mathematics(), vol 11. Birkhäuser, Cham. https://doi.org/10.1007/978-3-030-25261-8_23

Download citation

Publish with us

Policies and ethics