Abstract
Curcumin has the potential as a therapeutic drug having wider pharmacological application. But due to its lipophilicity, it exhibits a deprived serum level absorption rate, resulting in rapid systemic elimination. Conjugation of curcumin in a polymeric micelle increase the bioavailability of curcumin as a drug delivery system. β-Cyclodextrins, being circular oligosaccharides with an α (1–4) linked α-D-glucopyranose structure, along with a lipophilic center and hydrophilic outer surface, entraps the curcumin in the central cavity. In this present work, encapsulated curcumin was prepared and characterized using FTIR, PSA, Zeta potential, EDAX and TEM. Carrageenan based hydrogel films loaded with β-CD/Curcumin were synthesized as a wound dressing material. Further, to understand release kinetics of encapsulated curcumin in hydrogel film, release behaviour of curcumin was carried out and the data was fitted in different models. Free radical scavenging activity studies showed the potency of β-CD/Curcumin loaded carrageenan hydrogel as a wound dressing material.
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Rajan, A.S., Sheen, K.M., Sadhasivam, B., Saraswathy, N. (2019). In-Vitro Wound Healing and Release Kinetics of β-Cyclodextrin Encapsulated Curcumin Loaded Carrageenan Hydrogel Film: An Efficient Wound Dressing Material. In: Rajan, M., Anand, K., Chuturgoon, A. (eds) Proceedings of the International Conference on Nanomedicine (ICON-2019). ICON 2019. Springer Proceedings in Materials. Springer, Cham. https://doi.org/10.1007/978-3-030-25135-2_11
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