Other Malignant Tumors of the Thyroid and Metastatic Tumors to the Thyroid

  • Rema Rao
  • Theresa Scognamiglio
  • Rana S. HodaEmail author


  • This chapter discusses three other malignant tumors affecting the thyroid:
    • Anaplastic thyroid carcinomas (ATC)

    • Poorly differentiated thyroid carcinoma (PDCa)

    • Primary thyroid lymphoma


Anaplastic thyroid carcinoma Poorly differentiated thyroid carcinoma Papillary thyroid carcinoma Lymphomas involving thyroid gland Metastatic tumors to thyroid gland Metastatic breast carcinoma Metastatic renal carcinoma Metastatic lung carcinoma Metastatic colorectal carcinoma 

Suggested Reading

Anaplastic Thyroid Carcinomas

  1. 1.
    Molinaro E, Romei C, Biagini A, Sabini E, Agate L, Mazzeo S, et al. Anaplastic thyroid carcinoma: from clinicopathology to genetics and advanced therapies. Nat Rev Endocrinol. 2017;13:644–60. Scholar
  2. 2.
    Ragazzi M, Ciarrocchi A, Sancisi V, Gandolfi G, Bisagni A, Piana S. Update on anaplastic thyroid carcinoma: morphological, molecular, and genetic features of the most aggressive thyroid cancer. Int J Endocrinol. 2014;2014:790834. Scholar
  3. 3.
    Talbott I, Wakely PE Jr. Undifferentiated (anaplastic) thyroid carcinoma: practical immunohistochemistry and cytologic look-alikes. Semin Diagn Pathol. 2015;32:305–10. Scholar
  4. 4.
    Xu B, Ghossein R. Genomic landscape of poorly differentiated and anaplastic thyroid carcinoma. Endocr Pathol. 2016;27:205–12. Scholar

Poorly Differentiated Thyroid Carcinoma

  1. 5.
    Bongiovanni M, Bloom L, Krane JF, Baloch ZW, Powers CN, Hintermann S, et al. Cytomorphologic features of poorly differentiated thyroid carcinoma: a multi-institutional analysis of 40 cases. Cancer. 2009;117:185–94. Scholar
  2. 6.
    Bongiovanni M, Sadow PM, Faquin WC. Poorly differentiated thyroid carcinoma: a cytologic-histologic review. Adv Anat Pathol. 2009;16:283–9. Scholar
  3. 7.
    Kane SV, Sharma TP. Cytologic diagnostic approach to poorly differentiated thyroid carcinoma: a single-institution study. Cancer Cytopathol. 2015;123:82–91. Scholar
  4. 8.
    Saglietti C, Onenerk AM, Faquin WC, Sykiotis GP, Ziadi S, Bongiovanni M. FNA diagnosis of poorly differentiated thyroid carcinoma. A review of the recent literature. Cytopathology. 2017;28:467–74. Scholar

Primary Thyroid Lymphoma

  1. 9.
    Chen E, Wu Q, Jin Y, Jin W, Cai Y, Wang Q, et al. Clinicopathological characteristics and prognostic factors for primary thyroid lymphoma: report on 28 Chinese patients and results of a population-based study. Cancer Manag Res. 2018;10:4411–9. Scholar
  2. 10.
    Hirokawa M, Kudo T, Ota H, Suzuki A, Kobayashi K, Miyauchi A. Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry. Endocr J. 2017;64:859–65. Scholar
  3. 11.
    Zhang L, Castellana M, Virili C, Crescenzi A, Giorgino F, Zucca E, et al. Fine-needle aspiration to diagnose primary thyroid lymphoma: a systematic review and meta-analysis. Eur J Endocrinol. 2018; pii:EJE-18-0672.R1. [Epub ahead of print].

Metastatic Tumors to the Thyroid Gland

  1. 12.
    Beutner U, Leowardi C, Bork U, Luthi C, Tarantino I, Pahernik S, et al. Survival after renal cell carcinoma metastasis to the thyroid: single center experience and systematic review of the literature. Thyroid. 2015;25:314–24. Scholar
  2. 13.
    Hegerova L, Griebeler ML, Reynolds JP, Henry MR, Gharib H. Metastasis to the thyroid gland: report of a large series from the Mayo Clinic. Am J Clin Oncol. 2015;38:338–42. Scholar
  3. 14.
    Lee CH, Chung SY, Moon KC, Park IA, Chung YR, Ryu HS. A pilot study evaluating fine-needle aspiration cytology of clear-cell renal cell carcinoma: comparison of ancillary immunocytochemistry and cytomorphological characteristics of SurePath liquid-based preparations with conventional smears. Acta Cytol. 2015;59:239–47. Scholar
  4. 15.
    Magers MJ, Dueber JC, Lew M, Pang JC, Davenport RD. Metastatic ductal carcinoma of the breast to the thyroid gland diagnosed with fine needle aspiration: a case report with emphasis on morphologic and immunophenotypic features. Diagn Cytopathol. 2016;44:530–4. Scholar
  5. 16.
    Moghaddam PA, Cornejo KM, Khan A. Metastatic carcinoma to the thyroid gland: a single institution 20-year experience and review of the literature. Endocr Pathol. 2013;24:116–24. Scholar
  6. 17.
    Stevens TM, Richards AT, Bewtra C, Sharma P. Tumors metastatic to thyroid neoplasms: a case report and review of the literature. Pathol Res Int. 2011;2011:238693. Scholar
  7. 18.
    Zhang L, Liu Y, Li X, Gao W, Zheng C. Metastases to the thyroid gland: a report of 32 cases in PUMCH. Medicine (Baltimore). 2017;96:e7927. Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineNew York Presbyterian Hospital, Weill Cornell Medical CollegeNew YorkUSA
  2. 2.CBLPathRye BrookUSA

Personalised recommendations