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Early Childhood Contributions to Insulin Resistance

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Insulin Resistance

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

This chapter reviews what has been learnt about how pathways from smaller size at birth through rapid infancy weight gain lead to future disease risk. The association between low birth weight and increased risk for type 2 diabetes (T2D), in particular, is often only evident after allowing for larger current body size, implying a dependence on the transition from smaller size at birth to overweight or obesity in adulthood. The link between T2D risk and the transition from smaller size at birth to larger childhood size has been attributed to the development of insulin resistance.

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References

  1. Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. Lancet. 1989;2(8663):577–80.

    Article  CAS  PubMed  Google Scholar 

  2. Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia. 1992;35(7):595–601.

    Article  CAS  PubMed  Google Scholar 

  3. Hales CN, Barker DJ, Clark PM, Cox LJ, Fall C, Osmond C, et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 1991;303(6809):1019–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lucas A, Fewtrell MS, Cole TJ. Fetal origins of adult disease-the hypothesis revisited. BMJ. 1999;319(7204):245–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Ong KK, Ahmed ML, Emmett PM, Preece MA, Dunger DB. Association between postnatal catch-up growth and obesity in childhood: prospective cohort study. BMJ. 2000;320(7240):967–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Bavdekar A, Yajnik CS, Fall CH, Bapat S, Pandit AN, Deshpande V, et al. Insulin resistance syndrome in 8-year-old Indian children: small at birth, big at 8 years, or both? Diabetes. 1999;48(12):2422–99.

    Article  CAS  PubMed  Google Scholar 

  7. Crowther NJ, Cameron N, Trusler J, Gray IP. Association between poor glucose tolerance and rapid post natal weight gain in seven-year-old children. Diabetologia. 1998;41(10):1163–7.

    Article  CAS  PubMed  Google Scholar 

  8. Whincup PH, Cook DG, Adshead F, Taylor SJ, Walker M, Papacosta O, et al. Childhood size is more strongly related than size at birth to glucose and insulin levels in 10–11-year-old children. Diabetologia. 1997;40(3):319–26.

    Article  CAS  PubMed  Google Scholar 

  9. Yajnik CS, Fall CH, Vaidya U, Pandit AN, Bavdekar A, Bhat DS, et al. Fetal growth and glucose and insulin metabolism in four-year-old Indian children. Diabet Med. 1995;12(4):330–6.

    Article  CAS  PubMed  Google Scholar 

  10. Ong KK, Petry CJ, Emmett PM, Sandhu MS, Kiess W, Hales CN, et al. Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels. Diabetologia. 2004;47(6):1064–70.

    Article  CAS  PubMed  Google Scholar 

  11. Barker DJ, Eriksson JG, Forsen T, Osmond C. Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol. 2002;31(6):1235–9.

    Article  CAS  PubMed  Google Scholar 

  12. Lawlor DA, Ronalds G, Clark H, Smith GD, Leon DA. Birth weight is inversely associated with incident coronary heart disease and stroke among individuals born in the 1950s: findings from the Aberdeen Children of the 1950s prospective cohort study. Circulation. 2005;112(10):1414–8.

    Article  PubMed  Google Scholar 

  13. Leon DA, Lithell HO, Vâgerö D, Koupilová I, Mohsen R, Berglund L, et al. Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15 000 Swedish men and women born 1915–1929. BMJ. 1998;317(7153):241–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Rich-Edwards JW, Kleinman K, Michels KB, Stampfer MJ, Manson JE, Rexrode KM, et al. Longitudinal study of birth weight and adult body mass index in predicting risk of coronary heart disease and stroke in women. BMJ. 2005;330(7500):1115.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Barker DJ, Bull AR, Osmond C, Simmonds SJ. Fetal and placental size and risk of hypertension in adult life. BMJ. 1990;301(6746):259–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Curhan GC, Chertow GM, Willett WC, Spiegelman D, Colditz GA, Manson JE, et al. Birth weight and adult hypertension and obesity in women. Circulation. 1996;94(6):1310–5.

    Article  CAS  PubMed  Google Scholar 

  17. Curhan GC, Willett WC, Rimm EB, Spiegelman D, Ascherio AL, Stampfer MJ. Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation. 1996;94(12):3246–50.

    Article  CAS  PubMed  Google Scholar 

  18. Lundgren EM, Cnattingius S, Jonsson B, Tuvemo T. Intellectual and psychological performance in males born small for gestational age with and without catch-up growth. Pediatr Res. 2001;50(1):91–6.

    Article  CAS  PubMed  Google Scholar 

  19. Martyn CN, Barker DJ, Osmond C. Mothers’ pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UK. Lancet. 1996;348(9037):1264–8.

    Article  CAS  PubMed  Google Scholar 

  20. Rich-Edwards JW, Colditz GA, Stampfer MJ, Willett WC, Gillman MW, Hennekens CH, et al. Birthweight and the risk for type 2 diabetes mellitus in adult women. Ann Intern Med. 1999;130(4 Pt 1):278–84.

    Article  CAS  PubMed  Google Scholar 

  21. Zhao M, Shu XO, Jin F, Yang G, Li HL, Liu DK, et al. Birthweight, childhood growth and hypertension in adulthood. Int J Epidemiol. 2002;31(5):1043–51.

    Article  PubMed  Google Scholar 

  22. Lindsay RS, Dabelea D, Roumain J, Hanson RL, Bennett PH, Knowler WC. Type 2 diabetes and low birth weight: the role of paternal inheritance in the association of low birth weight and diabetes. Diabetes. 2000;49(3):445–9.

    Article  CAS  PubMed  Google Scholar 

  23. McCance DR, Pettitt DJ, Hanson RL, Jacobsson LT, Knowler WC, Bennett PH. Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype? BMJ. 1994;308(6934):942–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Dabelea D, Hanson RL, Lindsay RS, Pettitt DJ, Imperatore G, Gabir MM, et al. Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes. 2000;49(12):2208–11.

    Article  CAS  PubMed  Google Scholar 

  25. Eriksson JG, Forsen TJ, Osmond C, Barker DJ. Pathways of infant and childhood growth that lead to type 2 diabetes. Diabetes Care. 2003;26(11):3006–10.

    Article  PubMed  Google Scholar 

  26. Ravelli GP, Stein ZA, Susser MW. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med. 1976;295(7):349–53.

    Article  CAS  PubMed  Google Scholar 

  27. Gale CR, Martyn CN, Kellingray S, Eastell R, Cooper C. Intrauterine programming of adult body composition. J Clin Endocrinol Metab. 2001;86(1):267–72.

    CAS  PubMed  Google Scholar 

  28. McKeigue PM, Lithell HO, Leon DA. Glucose tolerance and resistance to insulin-stimulated glucose uptake in men aged 70 years in relation to size at birth. Diabetologia. 1998;41(10):1133–8.

    Article  CAS  PubMed  Google Scholar 

  29. Bundred P, Kitchiner D, Buchan I. Prevalence of overweight and obese children between 1989 and 1998: population based series of cross sectional studies. BMJ. 2001;322(7282):326–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Reilly JJ, Dorosty AR, Emmett PM. Prevalence of overweight and obesity in British children: cohort study. BMJ. 1999;319(7216):1039.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Widdowson EM, McCance RA. A review: new thoughts on growth. Pediatr Res. 1975;9(3):154–6.

    Article  CAS  PubMed  Google Scholar 

  32. Ong KK, Preece MA, Emmett PM, Ahmed ML, Dunger DB. Size at birth and early childhood growth in relation to maternal smoking, parity and infant breast-feeding: longitudinal birth cohort study and analysis. Pediatr Res. 2002;52(6):863–7.

    Article  PubMed  Google Scholar 

  33. Ounsted M, Scott A, Moar VA. Constrained and unconstrained fetal growth: associations with some biological and pathological factors. Ann Hum Biol. 1988;15(2):119–29.

    Article  CAS  PubMed  Google Scholar 

  34. Ounsted M, Scott A, Ounsted C. Transmission through the female line of a mechanism constraining human fetal growth. Ann Hum Biol. 1986;13(2):143–51.

    Article  CAS  PubMed  Google Scholar 

  35. Casteels K, Ong K, Phillips D, Bendall H, Pembrey M. Mitochondrial 16189 variant, thinness at birth, and type-2 diabetes. ALSPAC study team. Avon longitudinal study of pregnancy and childhood. Lancet. 1999;353(9163):1499–500.

    Article  CAS  PubMed  Google Scholar 

  36. Petry CJ, Ong KK, Barratt BJ, Wingate D, Cordell HJ, Ring SM, et al. Common polymorphism in H19 associated with birth-weight and cord blood IGF-II levels in humans. BMC Genet. 2005;6(1):22.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  37. Engel N, West AG, Felsenfeld G, Bartolomei MS. Antagonism between DNA hypermethylation and enhancer-blocking activity at the H19 DMD is uncovered by CpG mutations. Nat Genet. 2004;36(8):883–8.

    Article  CAS  PubMed  Google Scholar 

  38. Seghieri G, Anichini R, Bellis A, De Alviggi L, Franconi F, Breschi MC. Relationship between gestational diabetes mellitus and low maternal birth weight. Diabetes Care. 2002;25(10):1761–5.

    Article  PubMed  Google Scholar 

  39. Gohlke BC, Huber A, Hecher K, Fimmers R, Bartmann P, Roth CL. Fetal insulin-like growth factor (IGF)-I, IGF-II, and ghrelin in association with birth weight and postnatal growth in monozygotic twins with discordant growth. J Clin Endocrinol Metab. 2005;90(4):2270–4.

    Article  CAS  PubMed  Google Scholar 

  40. Ong KK, Ahmed ML, Sherriff A, Woods KA, Watts A, Golding J, et al. Cord blood leptin is associated with size at birth and predicts infancy weight gain in humans. ALSPAC Study Team. Avon longitudinal study of pregnancy and childhood. J Clin Endocrinol Metab. 1999;84(3):1145–8.

    Article  CAS  PubMed  Google Scholar 

  41. Ong KK, Emmett PM, Noble S, Ness A, Dunger DB. Dietary energy intake at the age of 4 months predicts postnatal weight gain and childhood body mass index. Pediatrics. 2006;117(3):e503–8.

    Article  PubMed  Google Scholar 

  42. Dunger DB, Ong KK, Huxtable SJ, Sherriff A, Woods KA, Ahmed ML, et al. Association of the INS VNTR with size at birth. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Nat Genet. 1998;19(1):98–100.

    Article  CAS  PubMed  Google Scholar 

  43. Stettler N, Bovet P, Shamlaye H, Zemel BS, Stallings VA, Paccaud F. Prevalence and risk factors for overweight and obesity in children from Seychelles, a country in rapid transition: the importance of early growth. Int J Obes Relat Metab Disord. 2002;26(2):214–9.

    Article  CAS  PubMed  Google Scholar 

  44. Stettler N, Zemel BS, Kumanyika S, Stallings VA. Infant weight gain and childhood overweight status in a multicenter, cohort study. Pediatrics. 2002;109(2):194–9.

    Article  PubMed  Google Scholar 

  45. Ekelund U, Ong K, Linné Y, Neovius M, Brage S, Dunger DB, et al. Upward weight percentile crossing in infancy and early childhood independently predicts fat mass in young adults: the Stockholm Weight Development Study (SWEDES). Am J Clin Nutr. 2006;83(2):324–30.

    Article  CAS  PubMed  Google Scholar 

  46. Law CM, Barker DJ, Osmond C, Fall CH, Simmonds SJ. Early growth and abdominal fatness in adult life. J Epidemiol Community Health. 1992;46(3):184–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Loos RJ, Beunen G, Fagard R, Derom C, Vlietinck R. Birth weight and body composition in young adult men – a prospective twin study. Int J Obes Relat Metab Disord. 2001;25(10):1537–45.

    Article  CAS  PubMed  Google Scholar 

  48. Loos RJ, Beunen G, Fagard R, Derom C, Vlietinck R. Birth weight and body composition in young women: a prospective twin study. Am J Clin Nutr. 2002;75(4):676–82.

    Article  CAS  PubMed  Google Scholar 

  49. Yajnik C. Interactions of perturbations in intrauterine growth and growth during childhood on the risk of adult-onset disease. Proc Nutr Soc. 2000;59(2):257–65.

    Article  CAS  PubMed  Google Scholar 

  50. Hediger ML, Overpeck MD, Maurer KR, Kuczmarski RJ, McGlynn A, Davis WW. Growth of infants and young children born small or large for gestational age: findings from the Third National Health and Nutrition Examination Survey. Arch Pediatr Adolesc Med. 1998;152(12):1225–31.

    Article  CAS  PubMed  Google Scholar 

  51. Garnett SP, Cowell CT, Baur LA, Fay RA, Lee J, Coakley J, et al. Abdominal fat and birth size in healthy prepubertal children. Int J Obes Relat Metab Disord. 2001;25(11):1667–73.

    Article  CAS  PubMed  Google Scholar 

  52. Singhal A, Cole TJ, Lucas A. Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials. Lancet. 2001;357(9254):413–9.

    Article  CAS  PubMed  Google Scholar 

  53. Singhal A, Fewtrell M, Cole TJ, Lucas A. Low nutrient intake and early growth for later insulin resistance in adolescents born preterm. Lancet. 2003;361(9363):1089–97.

    Article  CAS  PubMed  Google Scholar 

  54. Ibanez L, Ong K, Dunger DB, de Zegher F. Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children. J Clin Endocrinol Metab. 2006;91(6):2153–8.

    Article  CAS  PubMed  Google Scholar 

  55. Bazaes RA, Salazar TE, Pittaluga E, Peña V, Alegría A, Iñiguez G, et al. Glucose and lipid metabolism in small for gestational age infants at 48 hours of age. Pediatrics. 2003;111(4 Pt 1):804–9.

    Article  PubMed  Google Scholar 

  56. Hales CN, Desai M, Ozanne SE. The thrifty phenotype hypothesis: how does it look after 5 years? Diabet Med. 1997;14(3):189–95.

    Article  CAS  PubMed  Google Scholar 

  57. Mericq V, Ong KK, Bazaes R, Peña V, Avila A, Salazar T, et al. Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestational-age children. Diabetologia. 2005;48(12):2609–14.

    Article  CAS  PubMed  Google Scholar 

  58. Soto N, Bazaes RA, Peña V, Salazar T, Avila A, Iñiguez G, et al. Insulin sensitivity and secretion are related to catch-up growth in small-for-gestational-age infants at age 1 year: results from a prospective cohort. J Clin Endocrinol Metab. 2003;88(8):3645–50.

    Article  CAS  PubMed  Google Scholar 

  59. Leger J, Levy-Marchal C, Bloch J, Pinet A, Chevenne D, Porquet D, et al. Reduced final height and indications for insulin resistance in 20 year olds born small for gestational age: regional cohort study. BMJ. 1997;315(7104):341–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Jaquet D, Gaboriau A, Czernichow P, Levy-Marchal C. Insulin resistance early in adulthood in subjects born with intrauterine growth retardation. J Clin Endocrinol Metab. 2000;85(4):1401–6.

    CAS  PubMed  Google Scholar 

  61. Hofman PL, Regan F, Jackson WE, Jefferies C, Knight DB, Robinson EM, et al. Premature birth and later insulin resistance. N Engl J Med. 2004;351(21):2179–86.

    Article  CAS  PubMed  Google Scholar 

  62. Hovi P, Andersson S, Eriksson JG, Järvenpää AL, Strang-Karlsson S, Mäkitie O, et al. Glucose regulation in young adults with very low birth weight. N Engl J Med. 2007;356(20):2053–63.

    Article  CAS  PubMed  Google Scholar 

  63. Davies AA, Smith GD, Ben-Shlomo Y, Litchfield P. Low birth weight is associated with higher adult total cholesterol concentration in men: findings from an occupational cohort of 25,843 employees. Circulation. 2004;110(10):1258–62.

    Article  PubMed  Google Scholar 

  64. Fagerberg B, Bondjers L, Nilsson P. Low birth weight in combination with catch-up growth predicts the occurrence of the metabolic syndrome in men at late middle age: the Atherosclerosis and Insulin Resistance study. J Intern Med. 2004;256(3):254–9.

    Article  CAS  PubMed  Google Scholar 

  65. Ibanez L, Ferrer A, Ong K, Amin R, Dunger D de Zegher F. Insulin sensitization early after menarche prevents progression from precocious pubarche to polycystic ovary syndrome. J Pediatr. 2004;144(1):23–9.

    Article  PubMed  Google Scholar 

  66. Leeson CP, Kattenhorn M, Morley R, Lucas A, Deanfield JE. Impact of low birth weight and cardiovascular risk factors on endothelial function in early adult life. Circulation. 2001;103(9):1264–8.

    Article  CAS  PubMed  Google Scholar 

  67. Liese AD, Mayer-Davis EJ, Haffner SM. Development of the multiple metabolic syndrome: an epidemiologic perspective. Epidemiol Rev. 1998;20(2):157–72.

    Article  CAS  PubMed  Google Scholar 

  68. Stumvoll M, Tataranni PA, Bogardus C. The hyperbolic law – a 25-year perspective. Diabetologia. 2005;48(2):207–9.

    Article  CAS  PubMed  Google Scholar 

  69. Phillips DI, Clark PM, Hales CN, Osmond C. Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabet Med. 1994;11(3):286–92.

    Article  CAS  PubMed  Google Scholar 

  70. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–9.

    Article  CAS  PubMed  Google Scholar 

  71. Iñiguez G, Ong K, Bazaes R, Avila A, Salazar T, Dunger D, et al. Longitudinal changes in insulin-like growth factor-I, insulin sensitivity, and secretion from birth to age three years in small-for-gestational-age children. J Clin Endocrinol Metab. 2006;91(11):4645–9.

    Article  PubMed  CAS  Google Scholar 

  72. Low LC, Tam SY, Kwan EY, Tsang AM, Karlberg J. Onset of significant GH dependence of serum IGF-I and IGF-binding protein 3 concentrations in early life. Pediatr Res. 2001;50(6):737–42.

    Article  CAS  PubMed  Google Scholar 

  73. Silbergeld A, Lazar L, Erster B, Keret R, Tepper R, Laron Z. Serum growth hormone binding protein activity in healthy neonates, children and young adults: correlation with age, height and weight. Clin Endocrinol (Oxf). 1989;31(3):295–303.

    Article  CAS  Google Scholar 

  74. Williams DR, Wareham NJ, Brown DC, Byrne CD, Clark PM, Cox BD, et al. Undiagnosed glucose intolerance in the community: the Isle of Ely Diabetes Project. Diabet Med. 1995;12(1):30–5.

    Article  PubMed  Google Scholar 

  75. Sandhu MS, Heald AH, Gibson JM, Cruickshank JK, Dunger DB, Wareham NJ. Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study. Lancet. 2002;359(9319):1740–5.

    Article  CAS  PubMed  Google Scholar 

  76. Consultation WE. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157–63.

    Article  Google Scholar 

  77. McKeigue PM, Shah B, Marmot MG. Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet. 1991;337(8738):382–6.

    Article  CAS  PubMed  Google Scholar 

  78. Godfrey KM, Barker DJ, Robinson S, Osmond C. Maternal birthweight and diet in pregnancy in relation to the infant’s thinness at birth. Br J Obstet Gynaecol. 1997;104(6):663–7.

    Article  CAS  PubMed  Google Scholar 

  79. Mathews F, Yudkin P, Neil A. Influence of maternal nutrition on outcome of pregnancy: prospective cohort study. BMJ. 1999;319(7206):339–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Rogers I, Emmett P, Baker D, Golding J. Financial difficulties, smoking habits, composition of the diet and birthweight in a population of pregnant women in the South West of England. ALSPAC Study Team. Avon longitudinal study of pregnancy and childhood. Eur J Clin Nutr. 1998;52(4):251–60.

    Article  CAS  PubMed  Google Scholar 

  81. Hesse V, Voigt M, Sälzler A, Steinberg S, Friese K, Keller E, et al. Alterations in height, weight, and body mass index of newborns, children, and young adults in eastern Germany after German reunification. J Pediatr. 2003;142(3):259–62.

    Article  PubMed  Google Scholar 

  82. Franks PW, Looker HC, Kobes S, Touger L, Tataranni PA, Hanson RL, et al. Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring. Diabetes. 2006;55(2):460–5.

    Article  CAS  PubMed  Google Scholar 

  83. Haig D. Altercation of generations: genetic conflicts of pregnancy. Am J Reprod Immunol. 1996;35(3):226–32.

    Article  CAS  PubMed  Google Scholar 

  84. Neel JV. Diabetes mellitus: a “thrifty” genotype rendered detrimental by “progress”? Am J Hum Genet. 1962;14:353–62.

    CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics, University of Cambridge, Cambridge, UK

    David B. Dunger

  2. Department of Paediatrics, The Rosie Hospital, Cambridge University Hospitals, Cambridge, UK

    Burak Salgin

  3. MRC Epidemiology Unit, Department of Paediatrics, University of Cambridge, Cambridge, UK

    Ken K. Ong

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  1. David B. Dunger
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  2. Burak Salgin
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  3. Ken K. Ong
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Correspondence to David B. Dunger .

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Editors and Affiliations

  1. Section of Pediatric Endocrinology, Children’s Hospital Colorado, Aurora, CO, USA

    Philip S. Zeitler

  2. Department of Pediatrics, Children’s Hospital Colorado, Aurora, CO, USA

    Kristen J. Nadeau

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Dunger, D.B., Salgin, B., Ong, K.K. (2020). Early Childhood Contributions to Insulin Resistance. In: Zeitler, P., Nadeau, K. (eds) Insulin Resistance. Contemporary Endocrinology. Humana, Cham. https://doi.org/10.1007/978-3-030-25057-7_7

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