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Early Life Programming of Aging in Genetically Long-Lived Mice

  • Andrzej BartkeEmail author
  • Liou Sun
Chapter
Part of the Healthy Ageing and Longevity book series (HAL, volume 9)

Abstract

Mammalian aging and longevity are related to growth hormone (GH) actions and GH-dependent traits including growth, maturation and adult body size. In laboratory stocks of mice, genetic GH deficiency or resistance led to remarkable extension of healthspan and longevity. In GH-deficient Ames dwarf mice a brief period of GH replacement therapy normalizes (“rescues”) many adult aging-related traits and shortens longevity. This indicates that absence of GH signals during the period of rapid pre- and early post-weaning growth importantly contributes to slow and healthy aging of these long-lived mutants. More work is needed to define the role of GH at different stages of life history in the control of aging.

Keywords

Developmental programming Trajectory of aging Longevity Growth hormone signaling Healthspan 

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Internal MedicineSouthern Illinois University School of MedicineSpringfieldUSA
  2. 2.Department of BiologyUniversity of Alabama at BirminghamBirminghamUSA

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