General Biology of the Developmental Origins of Health

  • Michelle LamplEmail author
Part of the Healthy Ageing and Longevity book series (HAL, volume 9)


Health across the life span is predicted by cellular health as established in tissue and organ structure and function early in life. The cellular machinery of mitosis and the platforms for transcription-mediated cell differentiation give rise to phenotypic varieties of embodied experience through growth. Earliest cell fate decisions reflect stochastic processes. Competitive cell lineage commitments follow, encouraged by gene expression patterns influenced by the environment through hierarchical hub negotiations, and carried out by translational signaling. Cell-level negotiations emerge as the anlage for building multi-cellular bodies. Mechanistically linked to cell fate, metabolic strategies underlie early cell decisions and are core influences on variable phenotypic outcomes in changing environments. Fundamental biological processes, including oxidative stress, inflammation and stem cell regenerative potential mediate healthy aging at the cellular level. This chapter is an overview of fundamental biological platforms for developmental programming of life-course cell level dynamics involved in building the fetal body.


Stem cell Embryo Fetus Developmental programming ROS Healthy aging 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Center for the Study of Human Health, Emory UniversityAtlantaUSA

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