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Prenatal Undernutrition and Ageing and Longevity

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Early Life Origins of Ageing and Longevity

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 9))

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Abstract

Dietary restriction is one of the most extensively studied ways to elongate lifespan, but when species are undernourished before birth, effects are completely opposite. In the present chapter, evidence from animal experimental as well as from human studies is presented demonstrating that prenatal undernutrition increases the risk for ageing-associated diseases of the brain and the body, seems to accelerate the ageing process and decrease lifespan. The findings presented here are of importance from a public health perspective as prenatal nutrition may be a modifiable factor affecting healthy ageing. Also, understanding the processes by which prenatal undernutrition leads to accelerated ageing may provide clues on how we can detect early ageing and implement interventional approaches when conditions are still reversible.

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  1. Department of Clinical Epidemiology, Biostatistics & Bio Informatics, Amsterdam University Medical Centers, Location AMC, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

    Susanne R. de Rooij

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Correspondence to Susanne R. de Rooij .

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  1. Laboratory of Epigenetics, Institute of Gerontology, Kiev, Ukraine

    Alexander Vaiserman

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de Rooij, S.R. (2019). Prenatal Undernutrition and Ageing and Longevity. In: Vaiserman, A. (eds) Early Life Origins of Ageing and Longevity. Healthy Ageing and Longevity, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-030-24958-8_10

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