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MR Plaque Imaging in Peripheral Artery Disease

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Imaging in Peripheral Arterial Disease

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Abstract

Lower extremity peripheral artery disease (PAD) is one of the most common local manifestations of systemic atherosclerosis. In population studies conducted in the United States and Europe, PAD is estimated to affect approximately 7% of those aged ≥40 years and 21% of those aged ≥65 years. Globally, more than 200 million people are living with PAD, and the number is expected to continue to grow in the next decade due to aging populations worldwide and the increasing prevalence of chronic kidney disease and diabetes. The majority of PAD patients either have no apparent symptoms or have atypical symptoms due to individual variations in lifestyle, pain threshold, or comorbidities. Given the lack of effective medical therapies for PAD beyond exercise programs, understanding and prevention of disease progression at the subclinical stage represent an important question as prophylactic measures are likely most effective in the early stage of PAD.

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Abbreviations

ABI:

Ankle-brachial index

DANTE:

Delay alternating with mutation for tailored excitation

DESS:

Double-echo steady-state

DIR:

Double inversion recovery

FLASH:

Fast low-angle shot

FSE:

Fast spin echo

IPH:

Intraplaque hemorrhage

MERGE:

Motion-sensitized driven-equilibrium prepared rapid gradient echo

MPRAGE:

Magnetization-prepared rapid acquisition gradient echo

MSDE:

Motion-sensitized driven-equilibrium

PAD:

Peripheral artery disease

SFA:

Superficial femoral artery

SPACE:

Sampling perfection with application-optimized contrasts using different flip angle evolution

WALCS:

Walking and Leg Circulation Study

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Disclosures

Dr. Sun receives grant support from the American Heart Association (17MCPRP33671077). Dr. Yuan receives grant support from the National Institutes of Health (R01 HL103609 and R01 NS092207) and serves as a member of Philips Radiology Advisory Network.

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Authors and Affiliations

  1. Department of Radiology, University of Washington, Seattle, WA, USA

    Jie Sun

  2. University of Washington, Seattle, WA, USA

    Chun Yuan

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Correspondence to Chun Yuan .

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  1. Departments of Medicine and Radiology, University of Virginia, Charlottesville, VA, USA

    Christopher M. Kramer

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Sun, J., Yuan, C. (2020). MR Plaque Imaging in Peripheral Artery Disease. In: Kramer, C. (eds) Imaging in Peripheral Arterial Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-24596-2_10

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