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Clinical Neuroimmunology pp 197–212Cite as

Vitamin D and Multiple Sclerosis

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Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. Much has been learned about the role of vitamin D in MS, although our understanding remains incomplete. While the precise etiology of MS remains incompletely understood, low vitamin D status is one factor that appears to predispose to the development of MS, and patients with low 25(OH)D levels may be at greater risk of disease activity. Clinical trials are currently underway to more directly address the role of vitamin D supplementation in MS, yet further investigations are needed. This chapter reviews the role of vitamin D in the pathophysiology of MS and the evidence related to clinical outcomes in patients with MS who have vitamin D deficiency.

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Authors and Affiliations

  1. Department of Neurology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Billings Clinic, Billings, MT, USA

    Michael J. Bradshaw

  2. Department of Medicine, Boston University Medical Center, Boston, MA, USA

    Michael F. Holick

  3. Partners Multiple Sclerosis Center, Harvard Medical School, Boston, MA, USA

    James M. Stankiewicz

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  1. Michael J. Bradshaw
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  2. Michael F. Holick
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  3. James M. Stankiewicz
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Editor information

Editors and Affiliations

  1. Rhode Island Hospital and Alpert Medical School of Brown University, Brown Neurology, Providence, RI, USA

    Syed A. Rizvi

  2. Rhode Island Hospital and Alpert Medical School of Brown University, Brown Neurology, Providence, RI, USA

    Jonathan F. Cahill

  3. Department of Neurology, MS Comprehensive Care Center, Stony Brook University Medical Center, Stony Brook, NY, USA

    Patricia K. Coyle

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Bradshaw, M.J., Holick, M.F., Stankiewicz, J.M. (2020). Vitamin D and Multiple Sclerosis. In: Rizvi, S., Cahill, J., Coyle, P. (eds) Clinical Neuroimmunology. Current Clinical Neurology. Humana, Cham. https://doi.org/10.1007/978-3-030-24436-1_10

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  • DOI: https://doi.org/10.1007/978-3-030-24436-1_10

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