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Liver Ultrasonography

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Liver Diseases
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Abstract

Ultrasonography is a well-established technique of diagnosis in a very large number of pathologies. Besides, abdominal ultrasonography is one of the most commonly performed imagistic investigations in medicine, of high value in the exploration of parenchymatous organs, particularly the liver. It offers information about liver structure and vascularization, but also about possible pathologic processes that may occur in or around the liver. Recent technologic advances have made ultrasonography almost as reliable as CT scan or MRI in the evaluation of liver diseases, and its utility extends beyond diagnosis, as a mean of imagistic control in interventional procedures, such as liver biopsy or radiofrequency ablation. This work aims to review the normal and pathologic ultrasonographic imaging of the liver, in respect to its structure, blood and bile circulation.

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References

  1. Hassani S. Principles of ultrasonography. J Natl Med Assoc. 1974;66(3):205–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Ralls PW, Jeffrey RB Jr, Kane RA, Robbin ML. Diagnostic sonography. In: Yamada T, editor. Textbook of gastroenterology. 5th ed. Hoboken, NJ: Blackwell Publishing Ltd; 2009. p. 3083–113.

    Google Scholar 

  3. Hofer M. Ultrasound teaching manual - the basics of performing and interpreting ultrasound scans. Stuttgart: Thieme; 1999. p. 23–33.

    Google Scholar 

  4. Kudo M, Hirasa M, Takakuwa H, et al. Small hepatocellular carcinomas in chronic liver disease: detection with SPECT. Radiology. 1986;159:697.

    Article  CAS  Google Scholar 

  5. Penny S. Examination review for ultrasound: abdominal & obstetrics and gynecology. Philadelphia: Wolters Kluwer; 2018.

    Google Scholar 

  6. Borges VF, Diniz AL, Cotrim HP, Rocha HL, Andrade NB. Sonographic hepatorenal ratio: a noninvasive method to diagnose nonalcoholic steatosis. J Clin Ultrasound. 2013;41(1):18–25.

    Article  Google Scholar 

  7. Choi BI, Lee JY. The liver, Chapter 7. In: Lutz H, Buscarini E, editors. WHO manual of diagnostic ultrasound, vol. 1. 2nd ed. Malta: Gutenberg Press Ltd.; 2011. p. 139–67.

    Google Scholar 

  8. Guidelines for professional ultrasound practice. Society and College of Radiographers and British Medical Ultrasound Society, Revision 3; 2018.

    Google Scholar 

  9. EASL. EASL Clinical practice guidelines: vascular diseases of the liver. J Hepatol. 2015; https://doi.org/10.1016/j.jhep.2015.07.040.

  10. Grant EG. Parenchymal disease of the liver. In: Rifkin MD, Charboneau JW, Laing FC, editors. Ultrasound 1991 syllabus: special course. Oak Brook, IL: Radiological Society of North America; 1991. p. 281.

    Google Scholar 

  11. Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004;40(6):1387–95.

    Article  Google Scholar 

  12. Petritsch W, Pristautz H, Eber B. Is sonography superior to enzyme diagnosis in the detection of hepatic steatosis? Wien Klin Wochenschr. 1987;99(5):153–6.

    CAS  PubMed  Google Scholar 

  13. Ricci C, Longo R, Gioulis E, Bosco M, Pollesello P, Masutti F, et al. Noninvasive in vivo quantitative assessment of fat content in human liver. J Hepatol. 1997;27(1):108–13.

    Article  CAS  Google Scholar 

  14. Ahima RS. Insulin resistance: cause or consequence of nonalcoholic steatohepatitis? Gastroenterology. 2007;132(1):444–6.

    Article  CAS  Google Scholar 

  15. White EM, Simeone JF, Mueller PR, et al. Focal periportal sparing in hepatic fatty infiltration: a cause of hepatic pseudomass on US. Radiology. 1987;162:57.

    Article  CAS  Google Scholar 

  16. Forsberg L, Floren CH, Hederstrom E, et al. Ultrasound examination in diffuse liver disease. Clinical significance of enlarged lymph nodes in the hepatoduodenal ligament. Acta Radiol. 1987;28:281.

    Article  CAS  Google Scholar 

  17. Quinn SF, Gosink BB. Characteristic sonographic signs of hepatic fatty infiltration. AJR Am J Roentgenol. 1985;145:753.

    Article  CAS  Google Scholar 

  18. Gerstenmaier JF, Gibson RN. Ultrasound in chronic liver disease. Insights Imaging. 2014;5:441–55. https://doi.org/10.1007/s13244-014-0336-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Harbin WP, Robert NJ, Ferrucci JT Jr. Diagnosis of cirrhosis based on regional changes in hepatic morphology. Radiology. 1980;135:273.

    Article  CAS  Google Scholar 

  20. Choong CC, Venkatesh SK, Siew EP. Accuracy of routine clinical ultrasound for staging of liver fibrosis. J Clin Imaging Sci. 2012;2:58.

    Article  Google Scholar 

  21. Macarini L, Stoppino LP. Radiologic assessment of liver fibrosis – present and future, practical management of chronic viral hepatitis, Gaetano Serviddio. IntechOpen. https://doi.org/10.5772/55164. 2013. https://www.intechopen.com/books/practical-management-of-chronic-viral-hepatitis/radiologic-assessment-of-liver-fibrosis-present-and-future.

    Google Scholar 

  22. Hess CF, Schmiedl U, Koelbel G, et al. Diagnosis of liver cirrhosis with US; receiver-operating characteristic analysis of multidimensional caudate lobe indexes. Radiology. 1989;171:349.

    Article  CAS  Google Scholar 

  23. Lafortune M, Matricardi L, Denys A, Favret M, Dery R, Pomier-Layrargues G. Degment 4 (the quadrate lobe): a barometer of cirrhotic liver disease at US. Radiology. 1998;206:157–60.

    Article  CAS  Google Scholar 

  24. Wang TF, Hwang SJ, Lee EY, Tsai YT, Lin HC, Li CP, et al. Gall-bladder wall thickening in patients with liver cirrhosis. J Gastroenterol Hepatol. 1997;12(6):445–9.

    Article  CAS  Google Scholar 

  25. EASL. EASL clinical practice guidelines on the management of benign liver tumours. J Hepatol. 2016;65:386–98.

    Article  Google Scholar 

  26. D’Onofrio M, Crosara S, De Robertis R, Canestrini S, Mucelli RP. Contrast enhanced ultrasound of focal liver lesions. AJR Am J Roentgenol. 2015;205:W56–66.

    Article  Google Scholar 

  27. Richter J, Hatz C, Häussinger D. Ultrasound in tropical and parasitic diseases. Lancet. 2003;362(9387):900–2.

    Article  Google Scholar 

  28. Kuligowska E, Connors SK, Shapiro JH. Liver abscess: sonography in diagnosis and treatment. Am J Roentgenol. 1982;138(2):253–7.

    Article  CAS  Google Scholar 

  29. Quaia E, Bertolotto M, Dalla Palma L. Characterization of liver hemangiomas with pulse inversion harmonic imaging. Eur Radiol. 2002;12:537–44.

    Article  Google Scholar 

  30. Buetow PC, Pantongrag-Brown L, Buck JL, Ros PR, Goodman ZD. Focal nodular hyperplasia of the liver: radiologic-pathologic correlation. Radiographics. 1996;16:369–88.

    Article  CAS  Google Scholar 

  31. EASL. EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69:182–236.

    Article  Google Scholar 

  32. Kefeli A, Basyigit S, Yeniova AO. Diagnosis of hepatocellular carcinoma, updates in liver cancer. Hesham Mohamed Abdeldayem. IntechOpen. https://doi.org/10.5772/64992. 2017. https://www.intechopen.com/books/updates-in-liver-cancer/diagnosis-of-hepatocellular-carcinoma.

    Google Scholar 

  33. Forner A, Vilana R, Ayuso C, Bianchi L, Sole M, Ayuso JR, et al. Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology. 2008;47:97–104.

    Article  Google Scholar 

  34. Bolondi L, Sofia S, Siringo S, Gaiani S, Casali A, Zironi G, et al. Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis. Gut. 2001;48:251–9.

    Article  CAS  Google Scholar 

  35. Choi BI, Lee JH, Han MC, Kim SH, Yi JG, Kim CW. Hilar cholangiocarcinoma: comparative study with sonography and CT. Radiology. 1989;172:689–92.

    Article  CAS  Google Scholar 

  36. Kurtz AB, Middleton WD. Ultrasound: the requisites. St Louis, MO: Mosby-Year Book; 1996. p. 55–73.

    Google Scholar 

  37. Harding DJ, Perera M, Chen F, Olliff S, Tripathi D. Portal vein thrombosis in cirrhosis: controversies and latest developments. World JGastroenterol. 2015;21:6769–84.

    Article  Google Scholar 

  38. Aydinli M, Bayraktar Y. Budd-Chiari syndrome: etiology, pathogenesis and diagnosis. World J Gastroenterol. 2007;13(19):2693–6. https://doi.org/10.3748/wjg.v13.i19.2693.

    Article  PubMed  PubMed Central  Google Scholar 

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Self Study

Self Study

1.1 Questions

  1. 1.

    Which statement is true:

    1. (a)

      The patient must fast for a minimum of 6 h prior to the investigation.

    2. (b)

      Low frequency sounds are used for deep tissues (such as large livers).

    3. (c)

      High frequency sounds are used for high resolution images of superficial structures.

    4. (d)

      The frequency used in liver ultrasonography is 3–7 MHz.

  2. 2.

    Which statement is true:

    1. (a)

      Renal cortex is a reference for normal aspect of the liver echostructure.

    2. (b)

      The normal capsule appears as a fine continue hyperechoic line surrounding the liver.

    3. (c)

      The normal flow velocity in the portal vein ranges from 12 to 25 cm/s.

    4. (d)

      The hallmark sign for acute/chronic liver congestion is the distension of the inferior vena cava accompanied by the distension of hepatic veins.

  3. 3.

    Which statement is true about ultrasonography in liver cirrhosis:

    1. (a)

      The liver appears hypoechoic.

    2. (b)

      The liver contour is irregular.

    3. (c)

      The portal vein has a diameter of over 15 mm.

    4. (d)

      The intrahepatic portal vein branches have irregular caliber.

1.2 Answers

  1. 1.

    Which statement is true:

    1. (a)

      CORRECT

    2. (b)

      CORRECT

    3. (c)

      CORRECT

    4. (d)

      CORRECT

  2. 2.

    Which statement is true:

    1. (a)

      CORRECT

    2. (b)

      CORRECT

    3. (c)

      CORRECT

    4. (d)

      CORRECT

  3. 3.

    Which statement is true about ultrasonography in liver cirrhosis:

    1. (a)

      FALSE

    2. (b)

      CORRECT

    3. (c)

      CORRECT

    4. (d)

      CORRECT

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Iliescu, L. (2020). Liver Ultrasonography. In: Radu-Ionita, F., Pyrsopoulos, N., Jinga, M., Tintoiu, I., Sun, Z., Bontas, E. (eds) Liver Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-24432-3_40

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  • DOI: https://doi.org/10.1007/978-3-030-24432-3_40

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