Resistance to Chimeric Antigen Receptor T-Cell Therapy

  • Ana C. XavierEmail author
  • Luciano J. Costa
Part of the Resistance to Targeted Anti-Cancer Therapeutics book series (RTACT, volume 21)


Chimeric antigen receptor (CAR) T-cells are a form of adoptive immunotherapy constituted of autologous T-cells engineered with a receptors that is able to target tumor antigens. Treatment with CAR19 cells leads to rapid response in a significant proportion of patients with relapsed or refractory aggressive B-cell lymphomas. However, relapses post CAR-T cell therapy are common. In this chapter, we will discuss what is currently known about mechanisms of resistance to CAR-T cell therapy in B-cell lymphomas or leukemias.


Lymphoma Large B-cell Diffuse; immunotherapy Adoptive; drug resistance Neoplasm 



Acute Lymphoblastic Leukemia


Acute Myeloid Leukemia


Axicabtagene Ciloleucel


Copy-number Alteration


Chimeric Antigen Receptor


CAR-transduced B-cell leukemia


Complete Response


Cytokine Release Syndrome


Diffuse Large B-Cell Lymphoma


Lisocabtagene Maraleucel


Loss Of Heterozygosity


Mantle Cell Lymphoma


Overall Survival


Progression-Free Survival


Primary Mediastinal B-Cell Lymphoma


Partial Response




Response Rate


Stem Cell Transplant


T-Cell Receptor


DLBCL arising from Follicular Lymphoma




Whole-genome sequencing



The authors would like to thank Erin Morris, RN in her assistance in the preparation of this manuscript.

Disclosure of Conflict of Interest

L.J.M has received research support from Celgene, Janssen, Amgen, and GlaxoSmithKline; honorarium from Celgene, Amgen, Karyopharm, GlaxoSmithKline, and Kite; and speaker fees from Amgen and Sanofi. A.C.X has no conflict of interest to disclose.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Hematology/Oncology, Department of PediatricsUniversity of Alabama at Birmingham, Children’s Hospital of AlabamaBirminghamUSA
  2. 2.Division of Hematology/Oncology, Department of MedicineUniversity of Alabama at BirminghamBirminghamUSA

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