Resistance to Monoclonal Antibody Therapeutics in Lymphoma

  • Matthew J. BarthEmail author
  • Stanton C. Goldman
Part of the Resistance to Targeted Anti-Cancer Therapeutics book series (RTACT, volume 21)


With the long history of rituximab use in CD20 positive lymphomas and the recent approval of brentuximab vedotin for the treatment of Hodgkin lymphoma and anaplastic large cell lymphoma, monoclonal antibody-based therapies are commonly utilized for the treatment of many lymphomas. Following decades of experience with rituximab, much has been learned about the mechanisms of action and potential mechanisms of resistance to monoclonal antibody therapies, but a thorough understanding of which mechanisms of action are most relevant to rituximab’s efficacy and which resistance mechanisms are most clinically relevant is still elusive. Nonetheless, many approaches have been identified and continue to be investigated both pre-clinically and clinically to attempt to overcome or circumvent resistance to monoclonal antibody therapies in order to enhance treatment responses or improve survival at the time of relapse following monoclonal antibody based therapy.


Monoclonal antibody Antibody drug conjugate Non-Hodgkin lymphoma Hodgkin lymphoma Resistance 



Antibody-Dependent Cellular Cytotoxicity


Antibody-Dependent Phagocytic Cytotoxicity


Protein Kinase B


Anaplastic Large Cell Lymphoma


Acute Lymphoblastic Leukemia


B-cell Non-Hodgkin Lymphoma


Bispecific T-cell Engaging


Complement Dependent Cytotoxicity


Chronic Lymphocytic Leukemia


Diffuse Large B-Cell Lymphoma


Event-Free Survival


Extracellular signal Related Kinase 1 and 2


Granulocyte-Macrophage Colony Stimulating Factor


Human Anti-Chimera Antibodies


Interferon Gamma


Interleukin 2


Interleukin 4


Mitogen Activated Protein Kinase


Monomethyl Aurostatin E


Membrane Spanning 4-Domain A1


Nicotinamide Adenine Dinucleotide Phosphate


Nuclear Factor Kappa B


Natural Killer Cells


Programmed Cell Death


Phospholipase C Gamma 2




Reactive Oxygen Species


Signal Transducer and Activator of Transcription 3


Spleen Associated Tyrosine Kinase


Tumor Necrosis Factor alpha



S.C.G. is supported by Hyundai Hope on Wheels.

Disclosure of Conflict of Interest

No potential conflicts of interest were disclosed.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Pediatric Hematology/Oncology, Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloUSA
  2. 2.Department of PediatricsRoswell Park Comprehensive Cancer CenterBuffaloUSA
  3. 3.Division of Pediatric Hematology/OncologyMedical City Children’s HospitalDallasUSA

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