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The Mast Cell pp 25–34Cite as

Mast Cell Heterogeneity

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Abstract

Mast cells are strategically located at host/environment interfaces like skin, airways, and gastro-intestinal and uro-genital tracts. Mast cells also populate connective tissues in association with blood and lymphatic vessels and nerves. MCs are absent in avascular tissues, such as mineralized bone, cartilage, and cornea.

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References

  • Abou-Rabia N, Kendall MD (1994) Involution of the rat thymus in experimentally induced hypothyroidism. Cell Tissue Res 277:447–455

    Article  CAS  Google Scholar 

  • Barbini A, Gheri Bryk S, Balboni GC (1981) Behaviour of thymus mast cells in the rat under various experimental condition. Boll Soc Ital Biol Sper 57:645–650

    CAS  PubMed  Google Scholar 

  • Bischoff SC (2009) Physiological and pathophysiological functions of intestinal mast cells. Semin Immunopathol 31:185–205

    Article  CAS  Google Scholar 

  • Bischoff SC, Sellge G, Lorentz A et al (1999a) IL-4 enhances proliferation and mediator release in mature human mast cells. Proc Natl Acad Sci 96:8080–8085

    Article  CAS  Google Scholar 

  • Bischoff SC, Lorentz A, Schwengberg S et al (1999b) Mast cells are an important cellular source of tumour necrosis factor alpha in human intestinal tissue. Gut 44:643–652

    Article  CAS  Google Scholar 

  • Bjerknes M, Cheng H (1999) Clonal Analysis of mouse intestinal epithelial progenitors. Gastroenterology 116:7–14

    Article  CAS  Google Scholar 

  • Blair RJ, Meng H, Marchese MJ et al (1997) Tryptase is a novel, potent angiogenic factor. J Clin Invest 99:2691–2700

    Article  CAS  Google Scholar 

  • Bodey B, Calvo W, Prummer O et al (1987) Development and histogenesis of the thymus in dog. A light and electron microscopical study. Dev Comp Immunol 11:227–238

    Article  CAS  Google Scholar 

  • Brittan M, Wright NA (2002) Gastrointestinal stem cells. J Pathol 197:492–509

    Article  Google Scholar 

  • Brown JK, Knight PA, Pemberton AD et al (2004) Expression of integrin-alphae by mucolas mast cells in the intestinal epithelium and its absence in nematode-infected mice lacking the transforming growth factor-beta1-activating integrin alphav-Beta6. Am J Pathol 165:95–106

    Article  CAS  Google Scholar 

  • Cantin M, Veilleux R (1973) Effects of corticoids on granulocytes (Globule Leukocytes) and mastocytes of the urinary tract. Union Med Can 102:1502–1508

    CAS  PubMed  Google Scholar 

  • Crivellato E, Beltrami C, Mallardi F et al (2003a) Paul ehrlich’s doctoral thesis: a milestone in the study of mast cells. Br J Haematol 123:19–21

    Article  Google Scholar 

  • Crivellato E, Finato N, Isola M et al (2003b) Low mast cell density in the human duodenal mucosa from chronic inflammatory duodenal bowel disorders is associated with defective villous architecture. Eur J Clin Invest 33:601–610

    Article  CAS  Google Scholar 

  • Crivellato E, Nico B, Battistig M et al (2004) The thymus is a site of mast cell development in chicken embryos. Anat Embryol (Berl) 209:243–249

    Article  Google Scholar 

  • Crivellato E, Finato N, Ribatti D et al (2005) Do mast cells affect villous architecture? facts and conjectures. Histol Histopathol 20:1285–1293

    CAS  PubMed  Google Scholar 

  • Crivellato E, Finato N, Isola M et al (2006) Number of pericryptal fibroblasts correlates with density of distinct mast cell phenotypes in the crypt lamina propria of human duodenum: implications for the homeostasis of villous architecture. Anat Rec A Discov Mol Cell Evol Biol 288:593–600

    Article  Google Scholar 

  • Durkin HG, Waksman BH (2001) Thymus and tolerance. is regulation the major function of the thymus? Immunol Rev 182:33–57

    Article  CAS  Google Scholar 

  • Esposito P, Gheorghe D, Kandere K et al (2001) Acute stress increases permeability of the blood-brain barrier through activation brain mast cells. Brain Res 888:117–127

    Article  CAS  Google Scholar 

  • Galli SJ, Grimbaldeston M, Tsai M (2008a) Immunomodulatory Mast Cells: Negative, as well as Positive, Regulators of Immunity. Nat Rev Immunol 8:478–486

    Article  CAS  Google Scholar 

  • Galli SJ, Tsai M, Piliponski AM (2008b) The development of allergic inflammation. Nature 454:445–454

    Article  CAS  Google Scholar 

  • Gouon-Evans V, Pollard JW (2002) Unexpected deposition of brown fat in mammary gland during postnatal development. Mol Endocrinol 16:2618–2627

    Article  CAS  Google Scholar 

  • Gouon-Evans V, Rothenberg ME, Pollard JW (2000) Postnatal mammary gland development requires macrophages and eosinophils. Development 127:2269–2282

    CAS  PubMed  Google Scholar 

  • Groschwitz KR, Wu D, Osterfeld H et al (2013) Chymase-mediated intestinal epithelial permeability is regulated by a protese-activating receptor/matrix metalloproteinase-2-dependent mechanism. Am J Physiol Gastrointest Liver Physiol 304:G479–489

    Article  CAS  Google Scholar 

  • Gruber BL, Marchese MJ, Suzuki K et al (1989) Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation. J of Clin Invest 84:1657–1662

    Article  CAS  Google Scholar 

  • Gruber BL, Kew RR, Jelaska A et al (1997) Human mast cells activate fibroblasts. J Immunol 158:2310–2317

    CAS  PubMed  Google Scholar 

  • Grutzkau A, Kruger-Krasagakes S, Baumeister H et al (1998) Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF206. Mol Biol Cell 9:875–884

    Article  CAS  Google Scholar 

  • Hallgern J, Jones TG, Abonia JP et al (2007) Pulmonary CXCR55 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors. Proc Natl Acad Scie USA 104:20478–20483

    Article  Google Scholar 

  • Hellstrom B, Holgren H (1950) Numerical distribution of mast cells in the human skin and heart. Acta Anat 10:81–107

    Article  CAS  Google Scholar 

  • Irani AA, Schechter NM, Craig SS et al (1986) Two types of human mast cells that have distinct neutral protease compositions. Proc Natl Acad Sci USA 83:4464–4468

    Article  CAS  Google Scholar 

  • Irani AM, Craig SS, DeBlois G et al (1987) Deficiency of the tryptase-positive, chymase-negative mast cell type in gastrointestinal mucosa of patients with defective T lymphocyte function. J Immunol 138:4381–4386

    CAS  PubMed  Google Scholar 

  • Ito N, Sugawara K, Bodó E et al (2010) Corticotropin-releasing hormone stimulates the in situ generation of mast cells from precursors in the human hair follicle mesenchyme. J Invest Dermatol 130:995–1004

    Article  CAS  Google Scholar 

  • Jaafari-Ashkavandi Z, Ashraf MJ (2014) Increased mast cell counts in benign and malignant salivary gland tumors. J Dent Res Dent Clin Dent Prospects 8:15–20

    PubMed  PubMed Central  Google Scholar 

  • Jaffray D, Anderson TJ (1975) Mast cells in parathyroid glands. J Clin Pathol 28:765

    Article  CAS  Google Scholar 

  • Jamor MC, Oliver C (2011) Origin, maturation and recruitment of mast cell precursors. Front Biosci 3:1390–1406

    Google Scholar 

  • Karlsson L, Lindahl P, Heath JK et al (2000) Abnormal gastrointestinal development in PDGF-A and PDGFR-(Alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development 127:3457–3466

    CAS  PubMed  Google Scholar 

  • Kendall MD (1989) The morphology of perivascular spaces in the thymus. Thymus 13:157–164

    CAS  PubMed  Google Scholar 

  • Levi-Schaffer F, Pe’Er J (2001) Mast cells and angiogenesis. Clin Exp Allergy 31:521–524

    Article  CAS  Google Scholar 

  • Lilla JN, Werb Z (2010) Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis. Dev Biol 337:124–133

    Article  CAS  Google Scholar 

  • Lorton D, Bellinger DL, Felten SY et al (1990) Substance P innervation of the rat thymus. Peptides 11:1269–1275

    Article  CAS  Google Scholar 

  • Majeed SK (1994) Mast cell distribution in mice. Arzneimittelforschung 44:1170–1173

    CAS  PubMed  Google Scholar 

  • Maurer M, Theoharides T, Granstein RD et al (2003) What is the physiological function of mast cells? Exp Dermatol 12:886–886

    Article  CAS  Google Scholar 

  • Menzies FM, Shepherd MC, Nibbs RJ et al (2011) The role of mast cells and their mediators in reproduction, pregnancy and labour. Hum Reprod Update 17:383–396

    Article  CAS  Google Scholar 

  • Muller S, Weihe E (1991) Interrelation of peptidergic innervation with mast cells and ED1-positive cells in rat thymus. Brain Behav Immun 5:55–72

    Article  CAS  Google Scholar 

  • Murata K, Okudaira M, Akashio K (1973) Mast cells in human liver tissue. increased mast cell number in relation to the components of connective tissue in the cirrhotic process. Acta Derm Venereol Suppl (Stockh).73:157–165

    Google Scholar 

  • Nilsson G, Forsberg-Nilsson K, Xiang Z et al (1997) Human mast cells express functional Trka and are a source of nerve growth factor. Eur J Immunol 27:2295–2301

    Article  CAS  Google Scholar 

  • Olsson Y (1968) Mast cells in the nervous system. Int Rev Cytol 24:27–70

    Article  CAS  Google Scholar 

  • Paris F, Fuks Z, Kang A et al (2001) Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice. Science 293:293–297

    Article  CAS  Google Scholar 

  • Patella VMI, Lamparter B, Genovese A et al (1995) Immunologic and non-immunologic release of histamine and tryptase from human heart mast cells. Inflammat Res 44:22–23

    Article  Google Scholar 

  • Pesci A, Foresi A, Bertorelli G et al (1993) Histochemical characteristics and degranulation of mast cells in epithelium and lamina propria of bronchial biopsies from asthmatic and normal subjects. Am Rev Respir Dis 147:684–689

    Article  CAS  Google Scholar 

  • Qu Z, Kayton RJ, Ahmadi P et al (1998) Ultrastructural immunolocalization of basic fibroblast growth factor in mast cell secretory granules: morphological evidence for Bfgf release through degranulation. J Histochem Cytochem 46:1119–1128

    Article  CAS  Google Scholar 

  • Raica M, Cimpean AM, Nico B et al (2010) A Comparative study of the spatial distribution of mast cells and microvessels in the foetal, adult human thymus and thymoma. Int J Exp Pathol 91:17–23

    Article  Google Scholar 

  • Ribatti D, Crivellato E, Candussio L et al (2001a) Mast cells and their secretory granules are angiogenic in the chick embryo chorioallantoic membrane. Clin Exp Allergy 31:602–608

    Article  CAS  Google Scholar 

  • Ribatti D, Vacca A, Nico B et al (2001b) The role of mast cells in tumour angiogenesis. Brit J Haematol 115:514–521

    Article  CAS  Google Scholar 

  • Saarinen J, Kalkkinen N, Welgus HG et al (1994) Activation of human interstitial procollagenase through direct cleavage of the Leu3-Thr4 bond by mast cell chymase. J Biol Chem 269:18134–18140

    CAS  PubMed  Google Scholar 

  • Saruta T, Kondo K, Ohguro T et al (1977) Mast cells in human kidney cortex. Keio J Med 26:163–169

    Article  CAS  Google Scholar 

  • Sennikov SV, Temchura VV, Kozlov VA et al (2002) The influence of conditioned medium from mouse intestinal epithelial cells on the proliferative activity of crypt cells: role of granulocyte-macrophage colony-stimulating factor. J Gastroenterol 37:1048–1051

    Article  CAS  Google Scholar 

  • Soumelis V, Liu Y-J (2004) Human thymic stromal lymphopoietin: a novel epithelial cell-derived cytokine and a potential key player in the induction of allergic inflammation. Springer Semin Immunopathol 25:325–333

    Article  CAS  Google Scholar 

  • Stampachiacchiere B, Marinova T, Velikova K et al (2004) Altered levels of nerve growth factor in the thymus of subjects with myasthenia gravis. J Neuroimmunol 146:199–202

    Article  CAS  Google Scholar 

  • Tchougounova E, Lundequist A, Fajardo I et al (2005) A key role for mast cell chymase in the activation for pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2. J Biol Chem 280:9291–9296

    Article  CAS  Google Scholar 

  • Thabrew H, Cairns JA, Walls AF (1996) Mast cell tryptase is a growth factor for human airway smooth muscle. J Allergy Clin Immunol 97:969

    Article  Google Scholar 

  • Tsui-Pierchala BA, Milbrandt J, Johnson EM (2002) NGF utilizes c-ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons. Neuron 33:261–273

    Article  CAS  Google Scholar 

  • Visciano C, Prevete N, Liotti F et al (2015) Tumor-associated mast cells in thyroid cancer. Int J Endocrinol 2015:705169

    Article  Google Scholar 

  • Weber A, Knop J, Maurer M (2003) Pattern analysis of human cutaneous mast cell populations by total body surface mapping. Br J Dermatol 148:224–228

    Article  CAS  Google Scholar 

  • Weihe E, Müller S, Fink T et al (1989) Tachykinins, calcitonin gene-related peptide and neuropeptide Y in nerves of the mammalian thymus: interactions with mast cells in autonomic and sensory neuroimmunomodulation? Neurosci Lett 100:77–82

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biomedical Sciences, Neurosciences and Sensory Organs, University of Bari, Bari, Italy

    Domenico Ribatti

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  1. Domenico Ribatti
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Correspondence to Domenico Ribatti .

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Ribatti, D. (2019). Mast Cell Heterogeneity. In: The Mast Cell . Springer, Cham. https://doi.org/10.1007/978-3-030-24190-2_4

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