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Bilateral Internal Mammary Artery Grafting

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Cardiac Surgery
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Abstract

Coronary artery bypass grafting (CABG) remains the preferred revascularization option for patients with complex multi-vessel coronary artery disease. The standard grafting strategy in multi-vessel CABG involves the use of left internal mammary artery (IMA) for grafting of the left anterior descending artery and supplemental saphenous veins for all other target vessels. However, there is emerging evidence predominantly from retrospective, observational studies suggesting improved long-term outcomes with the use of bilateral IMAs. Despite the reported benefits of bilateral IMAs, most surgeons are reluctant to use both IMAs as it is a technically more demanding and time-consuming strategy with marginally higher sternal wound infection rates. This chapter provides an overview of bilateral IMA grafting exploring the rationale, surgical aspects as well as outcomes, concerns and controversies associated with this strategy.

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References

  1. Taggart DP. Best practices in coronary revascularization procedures: are we where we should be? Curr Opin Cardiol. 2014;29:28–33.

    Article  Google Scholar 

  2. Head SJ, Davierwala PM, Serruys PW, et al. Coronary artery bypass grafting vs. percutaneous coronary intervention for patients with three-vessel disease: final five-year follow-up of the SYNTAX trial. Eur Heart J. 2014;35:2821–30.

    Article  CAS  PubMed  Google Scholar 

  3. Hakeem A, Garg N, Bhatti S, Rajpurohit N, Ahmed Z, Uretsky BF. Effectiveness of percutaneous coronary intervention with drug-eluting stents compared with bypass surgery in diabetics with multivessel coronary disease: comprehensive systematic review and meta-analysis of randomized clinical data. J Am Heart Assoc. 2013;2:e000354.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Locker C, Schaff HV, Dearani JA, et al. Multiple arterial grafts improve late survival of patients undergoing coronary artery bypass graft surgery: analysis of 8622 patients with multivessel disease. Circulation. 2012;126:1023–30.

    Article  PubMed  Google Scholar 

  5. Raja SG, Siddiqui H, Ilsley CD, Amrani M. In-hospital outcomes of off-pump multivessel total arterial and conventional coronary artery bypass grafting: single surgeon, single center experience. Ann Thorac Surg. 2009;88:47–52.

    Article  PubMed  Google Scholar 

  6. Lytle BW, Blackstone EH, Sabik JF, Houghtaling P, Loop FD, Cosgrove DM. The effect of bilateral internal thoracic artery grafting on survival during 20 postoperative years. Ann Thorac Surg. 2004;78:2005–12.

    Article  PubMed  Google Scholar 

  7. Benedetto U, Amrani M, Raja SG, Harefield Cardiac Outcomes Research Group. Guidance for the use of bilateral internal thoracic arteries according to survival benefit across age groups. J Thorac Cardiovasc Surg. 2014;148:2706–11.

    Article  PubMed  Google Scholar 

  8. Tabata M, Grab JD, Khalpey Z, et al. Prevalence and variability of internal mammary artery graft use in contemporary multivessel coronary artery bypass graft surgery: analysis of the Society of Thoracic Surgeons National Cardiac Database. Effect of bilateral internal mammary artery grafts on long-term survival: a meta-analysis approach. Circulation. 2009;120:935–40.

    Article  PubMed  Google Scholar 

  9. Vineberg AM. Restoration of coronary circulation by anastomosis. Can Med Assoc J. 1946;55:117–9.

    PubMed  PubMed Central  Google Scholar 

  10. Kolesov VI, Potashov LV. Surgery of coronary arteries [in Russian]. Eksp Khir Anesteziol. 1965;10:3–8.

    CAS  PubMed  Google Scholar 

  11. Favaloro RG, Effler DB, Groves LK, et al. Double internal mammary artery-myocardial implantation, clinical evaluation of results in 150 patients. Circulation. 1968;37:549–55.

    Article  CAS  PubMed  Google Scholar 

  12. Cooley DA, Dawson JT, Hallman GL, et al. Aortocoronary saphenous vein bypass, results in 1,492 patients, with particular reference to patients with complicating features. Ann Thorac Surg. 1973;16:380–90.

    Article  CAS  PubMed  Google Scholar 

  13. Raja SG, Haider Z, Ahmad M, Zaman H. Saphenous vein grafts: to use or not to use? Heart Lung Circ. 2004;13:150–6.

    Article  PubMed  Google Scholar 

  14. Loop FD, Lytle BW, Cosgrove DM, et al. Influence of the internal mammary artery graft on 10-year survival and other cardiac events. N Engl J Med. 1986;314:1–6.

    Article  CAS  PubMed  Google Scholar 

  15. Lytle BW, Cosgrove DM, Saltus GL, et al. Multivessel coronary revascularization without saphenous vein: long term results of bilateral internal mammary artery grafting. Ann Thorac Surg. 1983;36:540–7.

    Article  CAS  PubMed  Google Scholar 

  16. Galbut DL, Traad EA, Dorman MJ, et al. Twelve-year experience with bilateral internal mammary artery grafts. Ann Thorac Surg. 1985;40:264–70.

    Article  CAS  PubMed  Google Scholar 

  17. Barner HB, Standeven JW, Reese J. Twelve-year experience with internal mammary artery for coronary artery bypass. J Thorac Cardiovasc Surg. 1985;90:668–75.

    Article  CAS  PubMed  Google Scholar 

  18. Rankin JS, Newman GE, Bashore TM, et al. Clinical and angiographic assessment of complex mammary artery bypass grafting. J Thorac Cardiovasc Surg. 1986;92:832–46.

    Article  CAS  PubMed  Google Scholar 

  19. Tector AJ, Schmahl TM, Canino VR. Expanding the use of the internal mammary artery to improve patency in coronary artery bypass grafting. J Thorac Cardiovasc Surg. 1986;91:9–16.

    Article  CAS  PubMed  Google Scholar 

  20. Sauvage LR, Wu HD, Koivalsky TE, et al. Healing basis and surgical techniques for complete revascularization of the left ventricle using only the internal mammary arteries. Ann Thorac Surg. 1986;42:449–65.

    Article  CAS  PubMed  Google Scholar 

  21. Taggart DP, D’Amico R, Altman DG. The effect of arterial revascularization on survival: a systematic review of studies comparing bilateral and single internal mammary arteries. Lancet. 2001;358:870–5.

    Article  CAS  PubMed  Google Scholar 

  22. Falk V. Coronary artery bypass grafting with bilateral internal thoracic arteries. Heart. 2013;99:821.

    Article  PubMed  Google Scholar 

  23. Davierwala PM, Mohr FW. Bilateral internal mammary artery grafting: rationale and evidence. Int J Surg. 2015;16(Pt B):133–9.

    Article  PubMed  Google Scholar 

  24. Ferraria G, Quackenbushc J, Strobecka J, et al. Comparative genome-wide transcriptional analysis of human left and right internal mammary arteries. Genomics. 2014;104:36–44.

    Article  CAS  Google Scholar 

  25. van Son JA, Smedts F, Vincent JG, et al. Comparative anatomic studies of various arterial conduits for myocardial revascularization. J Thorac Cardiovasc Surg. 1990;99:703–7.

    Article  PubMed  Google Scholar 

  26. Barner HB. Remodeling of arterial conduits in coronary grafting. Ann Thorac Surg. 2002;73:1341–5.

    Article  PubMed  Google Scholar 

  27. Lytle BW, Loop FD, Cosgrove DM, et al. Long-term (5 to 12 years) serial studies of internal mammary artery and saphenous vein coronary bypass grafts. J Thorac Cardiovasc Surg. 1985;89:248–58.

    Article  CAS  PubMed  Google Scholar 

  28. Ruttmann E, Fischler N, Sakic A, et al. Second internal thoracic artery versus radial artery in coronary artery bypass grafting: a long-term, propensity score-matched follow-up study. Circulation. 2011;124:1321–9.

    Article  PubMed  Google Scholar 

  29. Raja SG, Benedetto U, Jothidasan A, et al. Harefield Cardiac Outcomes Research Group. Right internal mammary artery versus radial artery as second arterial conduit in coronary artery bypass grafting: a case-control study of 1526 patients. Int J Surg. 2015;16:183–9.

    Article  PubMed  Google Scholar 

  30. Navia D, Vrancic M, Piccinini FF, et al. Is the second internal thoracic artery better than the radial artery in total arterial off-pump coronary artery bypass grafting? A propensity score-matched follow-up study. J Thorac Cardiovasc Surg. 2014;147:632–8.

    Article  PubMed  Google Scholar 

  31. Tranbaugh RF, Dimitrova KR, Lucido DJ, et al. The second best arterial graft: a propensity analysis of the radial artery versus the free right internal thoracic artery to bypass the circumflex coronary artery. J Thorac Cardiovasc Surg. 2014;147:133–40.

    Article  PubMed  Google Scholar 

  32. Raja SG. Surgical strategies for bilateral internal mammary artery grafting. Int J Surg. 2015;16(Pt B):140–5.

    Article  PubMed  Google Scholar 

  33. Puig LB, França Neto L, Rati M, et al. A technique of anastomosis of the right internal mammary artery to the circumflex artery and its branches. Ann Thorac Surg. 1984;38:533–4.

    Article  CAS  PubMed  Google Scholar 

  34. Cosgrove DM, Loop FD. Techniques to maximize mammary artery length. Ann Thorac Surg. 1985;40:78–9.

    Article  CAS  PubMed  Google Scholar 

  35. Lev-Ran O, Pevni D, Matsa M, Paz Y, Kramer A, Mohr R. Arterial myocardial revascularization with in situ crossover right internal thoracic artery to left anterior descending artery. Ann Thorac Surg. 2001;72:798–803.

    Article  CAS  PubMed  Google Scholar 

  36. Ascione R, Underwood MJ, Lloyd CT, Jeremy JY, Bryan AJ, Angelini GD. Clinical and angiographic outcome of different surgical strategies of bilateral internal mammary artery grafting. Ann Thorac Surg. 2001;72:959–65.

    Article  CAS  PubMed  Google Scholar 

  37. Pick AW, Orszulak TA, Anderson BJ, Schaff HV. Single versus bilateral internal mammary artery grafts: 10-year outcome analysis. Ann Thorac Surg. 1997;64:599–605.

    Article  CAS  PubMed  Google Scholar 

  38. Schmidt SE, Jones JW, Thornby JI, Miller CC 3rd, Beall AC Jr. Improved survival with multiple left-sided bilateral internal thoracic artery grafts. Ann Thorac Surg. 1997;64:9–14.

    Article  CAS  PubMed  Google Scholar 

  39. Gansera B, Angelis I, Botzenhardt F, Günzinger R, Neumaier-Prauser P, Kemkes BM. End of the millennium – end of the single mammary artery graft? Two internal mammary arteries – standard for the next millennium? Early clinical results and analysis of risk factors in 1487 patients with bilateral internal mammary artery bypass. Z Kardiol. 2003;92:398–406.

    Article  CAS  PubMed  Google Scholar 

  40. Stevens LM, Carrier M, Perrault LP, et al. Single versus bilateral internal thoracic artery grafts with concomitant saphenous vein grafts for multivessel coronary artery bypass grafting: effects on mortality and event-free survival. J Thorac Cardiovasc Surg. 2004;127:1408–15.

    Article  CAS  PubMed  Google Scholar 

  41. Taggart DP, Lees B, Gray A, Altman DG, Flather M, Channon K, ART Investigators. Protocol for the Arterial Revascularisation Trial (ART). A randomised trial to compare survival following bilateral versus single internal mammary grafting in coronary revascularisation [ISRCTN46552265]. Trials. 2006;7:7.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Galbut DL, Traad EA, Dorman MJ, et al. Seventeen-year experience with bilateral internal mammary artery grafts. Ann Thorac Surg. 1990;49:195–201.

    Article  CAS  PubMed  Google Scholar 

  43. Lytle BW, Blackstone EH, Loop FD, et al. Two internal thoracic artery grafts are better than one. J Thorac Cardiovasc Surg. 1999;117:8855–72.

    Article  Google Scholar 

  44. Kurlansky PA, Traad EA, Dorman MJ, et al. Thirty-year follow-up defines survival benefit for second internal mammary artery in propensity-matched groups. Ann Thorac Surg. 2010;90:101–8.

    Article  PubMed  Google Scholar 

  45. Weiss AJ, Zhao S, Tian DH, et al. A meta-analysis comparing bilateral internal mammary artery with left internal mammary artery for coronary artery bypass grafting. Ann Cardiothorac Surg. 2013;2:390–400.

    PubMed  PubMed Central  Google Scholar 

  46. Rankin JS, Tuttle RH, Wechsler AS, et al. Techniques and benefits of multiple internal mammary artery bypass at 20 years of follow-up. Ann Thorac Surg. 2007;83:1008–15.

    Article  PubMed  Google Scholar 

  47. Peterson MD, Borger MA, Rao V, Peniston CM, Feindel CM. Skeletonization of bilateral internal thoracic artery grafts lowers the risk of sternal infection in patients with diabetes. J Thorac Cardiovasc Surg. 2003;126:1314–9.

    Article  PubMed  Google Scholar 

  48. Pevni D, Mohr R, Lev-Ran O, et al. Influence of bilateral skeletonized harvesting on occurrence of deep sternal wound infection in 1,000 consecutive patients undergoing bilateral internal thoracic artery grafting. Ann Surg. 2003;237:277–80.

    PubMed  PubMed Central  Google Scholar 

  49. Matsa M, Paz Y, Gurevitch J, et al. Bilateral skeletonized internal thoracic artery grafts in patients with diabetes mellitus. J Thorac Cardiovasc Surg. 2001;121:668–74.

    Article  CAS  PubMed  Google Scholar 

  50. Kramer A, Mastsa M, Paz Y, et al. Bilateral skeletonized internal thoracic artery grafting in 303 patients seventy years and older. J Thorac Cardiovasc Surg. 2000;120:290–7.

    Article  CAS  PubMed  Google Scholar 

  51. Sofer D, Gurevitch J, Shapira I, et al. Sternal wound infections in patients after coronary artery bypass grafting using bilateral skeletonized internal mammary arteries. Ann Surg. 1999;229:585–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Bical O, Braunberger E, Fischer M, et al. Bilateral skeletonized mammary artery grafting (experience with 560 consecutive patients). Eur J Cardiothorac Surg. 1996;10:971–5.

    Article  CAS  PubMed  Google Scholar 

  53. Taggart DP, Altman DG, Gray AM, Lees B, Nugara F, Yu LM, Campbell H, Flather M, ART Investigators. Randomized trial to compare bilateral vs. single internal mammary coronary artery bypass grafting: 1-year results of the Arterial Revascularisation Trial (ART). Eur Heart J. 2010;31:2470–81.

    Article  PubMed  Google Scholar 

  54. Taggart DP, Altman DG, Gray AM, Lees B, Gerry S, Benedetto U, Flather M, ART Investigators. Randomized trial of bilateral versus single internal thoracic artery grafts. N Engl J Med. 2016;375:2540–9.

    Article  PubMed  Google Scholar 

  55. Taggart DP, Benedetto U, Flather M. Bilateral versus single internal thoracic-artery grafts. N Engl J Med. 2017;376:e37.

    Article  PubMed  Google Scholar 

  56. Kajimoto K, Yamamoto T, Amano A. Coronary artery bypass revascularization using bilateral internal thoracic arteries in diabetic patients: a systematic review and meta-analysis. Ann Thorac Surg. 2015;99:1097–104.

    Article  PubMed  Google Scholar 

  57. Umakanthan J, Jeyakumar P, Umakanthan B, et al. Barriers to the universal adoption of bilateral internal mammary artery grafting. Int J Surg. 2015;16(Pt B):179–82.

    Article  PubMed  Google Scholar 

  58. Buttar SN, Yan TD, Taggart DP, Tian DH. Long-term and short-term outcomes of using bilateral internal mammary artery grafting versus left internal mammary artery grafting: a meta-analysis. Heart. 2017;103:1419–26.

    Article  PubMed  Google Scholar 

  59. Medalion B, Katz MG, Lorberboym M, Bder O, Schachner A, Cohen AJ. Decreased sternal vascularity after internal thoracic artery harvesting resolves with time: an assessment with single photon emission computed tomography. J Thorac Cardiovasc Surg. 2002;123:508–11.

    Article  PubMed  Google Scholar 

  60. Toumpoulis IK, Anagnostopoulos CE, Derose JJ Jr, Swistel DG. The impact of deep sternal wound infection on long-term survival after coronary artery bypass grafting. Chest. 2005;127:464–71.

    Article  PubMed  Google Scholar 

  61. Taggart DP. Bilateral internal mammary artery grafting: are BIMA better? Heart. 2002;88:7–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Raja SG, Dreyfus GD. Internal thoracic artery: to skeletonize or not to skeletonize? Ann Thorac Surg. 2005;79:1805–11.

    Article  PubMed  Google Scholar 

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Correspondence to Shahzad G. Raja .

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Raja, S.G., Taggart, D. (2020). Bilateral Internal Mammary Artery Grafting. In: Raja, S. (eds) Cardiac Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-24174-2_21

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  • DOI: https://doi.org/10.1007/978-3-030-24174-2_21

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